Polyoxometalate-antioxidant peptide assembly materials with NIR-triggered photothermal behaviour and enhanced antibacterial activity

Zhang, Simin; Peng, Bo; Xue, Peiyu; Kong, Xueping; Tang, Yue; Wu, Lixin; Lin, Songyi

doi:10.1039/c9sm01059a

Cited by 22 publications

(14 citation statements)

References 43 publications

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“…Since both POMs and polypeptides have each been shown to exhibit potent antimicrobial properties, it therefore follows that hybrid materials based on these components emerge as interesting candidates to overcome the increasing problem of bacterial resistance towards conventional antibiotics [29–32] . The ionic combination of peptides or peptide‐polymers and POMs have resulted in hybrids with better antimicrobial activities than each component alone [33–35] . In addition, the vast combinatorial possibilities of both POMs and amino acids means that it is also possible to tune the secondary structure, molecular weight and antimicrobial properties of the hybrid.…”

Section: Figurementioning

confidence: 99%

On‐POM Ring‐Opening Polymerisation of N‐Carboxyanhydrides

et al. 2021

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The ring‐opening polymerisation of α‐amino acid N‐carboxyanhydrides (NCAs) offers a simple and scalable route to polypeptides with predicted and narrow molecular weight distributions. Here we show how polyoxometalates (POMs)—redox‐active molecular metal‐oxide anions—can serve as inorganic scaffold initiators for such NCA polymerisations. This “On‐POM polymerisation” strategy serves as an innovative platform to design hybrid materials with additive or synergistic properties stemming from the inorganic and polypeptide component parts. We have used this synthetic approach to synthesise a library of bactericidal poly(lysine)–POM hybrid derivatives that can be used to prevent biofilm formation. This versatile “On‐POM polymerisation” method provides a flexible synthetic approach for combining inorganic scaffolds with amino acids, and the potential to tailor and improve the specificity and performance of hybrid antimicrobial materials.

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Section: Figurementioning

confidence: 99%

On‐POM Ring‐Opening Polymerisation of N‐Carboxyanhydrides

et al. 2021

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“…In the case of POMs, the existence of a strong NIR absorption is due to the intervalence charge transfer (IVCT) between metal ions,, and has been explored to develop novel photothermal agents . In this context, the anions [GdW 10 O 36 ] 9– , [PMo 12 O 40 ] 3– , [PMo 2 W 10 O 40 ] 5– , and the big‐wheel {Mo 154 } have shown promising results. These studies are briefly summarised in Table and described in the next paragraphs.…”

Section: Polyoxometalate Composites For Pttmentioning

confidence: 99%

“…In an attempt to improve the stability of the [PMo 12 O 40 ] 3– anion in physiological medium and to prevent its oxidation, Zhang and collaborators prepared a hybrid material composed by the POM and a soybean pentapeptide, that presents antioxidant and antimicrobial ability. The cationic nature of the short peptide and the anionic nature of the POM allowed the formation of a supramolecular structure.…”

Section: Polyoxometalate Composites For Pttmentioning

confidence: 99%

Polyoxometalate Composites in Cancer Therapy and Diagnostics

et al. 2020

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Polyoxometalates (POMs) are metal‐oxide inorganic clusters, mostly anionic, where the metal is usually a transition metal (such as V, W, or Mo). Owing to their great variety of structures and large range of molecular dimensions, POMs have attracted considerable attention over the years. The high solubility in water together with the extent of their redox chemistry make POMs and their composites very versatile materials that find many applications in the biomedical field such as drug delivery systems or anti‐viral and anti‐tumoural agents. While the antitumoural activity of POMs and their derivatives is well documented, their application in emergent cancer therapies has not been addressed. This review presents the application of POM‐based composites as photothermal agents, radiosensitisers, and biosensors. The latest advances in the design of novel POM nanocomposites for cancer theranostics are also highlighted.

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“…By virtue of the redox and photothermal properties of POMs, Zhang et al fabricated a sort of novel tumor inhibitor and superior antibacterial agent based on ionic coassembled of pentapeptide (Ser-His-Cys-Met-Asn) and H 3 PMo 12 O 40 . [259] Despite these reports, the coassembly of cationic peptides and POMs always form irregular nanospheres due possibly to the bulky effect of POMs. To fabricate ordered coassembly nanostructures, Li et al designed and synthesized a series of facial-like peptides with alternating sequence of hydrophilic and hydrophobic residues.…”

Section: Cationic Peptides and Polyoxometalatesmentioning

confidence: 99%

“…fabricated a sort of novel tumor inhibitor and superior antibacterial agent based on ionic coassembled of pentapeptide (Ser‐His‐Cys‐Met‐Asn) and H 3 PMo 12 O 40 . [ 259 ]…”

Section: Cationic Peptides and Polyoxometalatesmentioning

confidence: 99%

Recent Progress in Ionic Coassembly of Cationic Peptides and Anionic Species

Xie

Zheng

2020

Macromol. Rapid Commun.

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innovative insight into understanding the properties of the material systems beyond molecular level. [6-8] Through the last decades, supramolecular chemistry has deeply permeated and fused with biology and materials science, and has gradually growth into an interdisciplinary platform for the creation of self-assembled systems with extraordinary properties. [9-12] Among the numerous systems, self-assembled peptide is one of the most important branches, because of its rich chemical diversity, versatile characters, inherent biocompatibility, and bioactivity. [13-15] Specifically, the natural or chemically engineered amino acids encoded in the sequence of peptide molecules enable the formation of customizable secondary structures, the cooperative interactions between main chains and side chains of peptide molecules can be further leveraged to produce hierarchical nanostructures [16-22] and important biofunctions, such as drug delivery, [23-25] tissue engineering, [26-28] regenerative medicine, [29-31] and biomineralization. [32-35] Moreover, many studies have disclosed that self-assembled peptide nanostructures can offer higher performance (catalytic, therapeutic, targeting, etc.) than peptide itself. [36-42] For those reasons, peptide self-assembly has been recognized as a subject of great importance in supramolecular chemistry, biology, and nanotechnology, and the breadth and depth of peptide selfassemblies have been documented and demonstrated in several excellent reviews. [43-51] Besides the self-assembly of unimolecular peptides, multicomponent coassembly between peptides and other building blocks has recently become increasingly prevalent, as the modular approach offers a simple and effective way to arrive at supramolecular materials with wide structural complexity and value-added properties for multiple tasks applications. [52-56] This integrated characteristic further stimulates researchers to explore the scope of peptide coassembly with the aim of expanding the space of functional utility. To selectively form the multicomponent nanostructures, the interplay of the driving forces should be energetically much more favorable for strengthening the coassembly of distinct components than the self-sorting of the same type of components. [57-59] Following this design criteria, the introduction of complementary noncovalent interactions into the multicomponent systems is Peptide assembly has been extensively exploited as a promising platform for the creation of hierarchical nanostructures and tailor-made bioactive materials. Ionic coassembly of cationic peptides and anionic species is paving the way to provide particularly important contribution to this topic. In this review, the recent progress of ionic coassembly soft materials derived from the electrostatic coupling between cationic peptides and anionic species in aqueous solution is systematically summarized. The presentation of this review starts from a brief background on the general importance and advantages of peptide-based ionic coassembly. After that, divers...

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Polyoxometalate-antioxidant peptide assembly materials with NIR-triggered photothermal behaviour and enhanced antibacterial activity

Abstract: A novel photothermal material based on a polyoxometalate-antioxidant peptide assembly with enhanced photothermal stability and enhanced antibacterial activity was exploited.

Cited by 22 publications

References 43 publications

On‐POM Ring‐Opening Polymerisation of N‐Carboxyanhydrides

On‐POM Ring‐Opening Polymerisation of N‐Carboxyanhydrides

Polyoxometalate Composites in Cancer Therapy and Diagnostics

Recent Progress in Ionic Coassembly of Cationic Peptides and Anionic Species

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