Polyostotic Fibrous Dysplasia of the Thoracic Spine

Chen, Guangdong; Yang, Huilin; Gan, Minfeng; Li, Xuefeng; Chen, Kangwu; Nalajala, Badri; Wang, Genlin

doi:10.1097/brs.0b013e3182028ae5

Cited by 13 publications

(6 citation statements)

References 27 publications

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“…Our literature review revealed only 7 patients (including the 1 patient reported in this study) who underwent VP for the treatment of spinal fibrous dysplasia, as shown in Table 2 [20, 23, 29–31]; 2 patients had MFD, and 5 had PFD. Pathological fractures occurred in 5 patients, involving 13 vertebrae.…”

Section: Discussionmentioning

confidence: 99%

Monostotic fibrous dysplasia at C7 treated with vertebroplasty: a case report and review of the literature

et al. 2019

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BackgroundMonostotic fibrous dysplasia (MFD) involving the spine is rare, and the treatment options are controversial. Surgery is needed when patients suffer from persistent pain, spinal cord compression/injury, and vertebral collapse/instability. Treatment methods include biopsy/observation, corpectomy with instrumented fusion, posterior fusion, vertebroplasty (VP), curettage and bone graft, and complete removal of the vertebra with a combined anterior and posterior fusion procedure.Case presentationThe patient was a 56-year-old woman with a 2-year history of neck pain. No obvious abnormalities were detected on neurological or physical examination, and laboratory findings were all within normal limits. An imaging examination suggested a C7 vertebral bone tumor. The patient refused to continue conservative observation treatment and requested surgery. Open VP of the C7 vertebral body was carried out, and her postoperative neck pain was completely relieved. The postoperative pathological results supported the diagnosis of fibrous dysplasia, and the patient was ultimately diagnosed with MFD. At the 12-month follow-up visit, the patient reported no clinical symptoms, and no signs of tumor recurrence were detected.ConclusionVP can relieve pain while stabilizing the spine. Thus, the surgical treatment of MFD vertebral lesions by VP is a valuable option.

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Section: Discussionmentioning

confidence: 99%

Monostotic fibrous dysplasia at C7 treated with vertebroplasty: a case report and review of the literature

et al. 2019

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“…Jayaraman M's case report showed that oral alendronate significantly reduced bone pain in a PFD patient and the patient's plain radiography showed reduction in lesion size [10]. Percutaneoous vertebroplasty (PVP) and balloon kyphoplasty (PKP) have been widely and successfully used in pain relief and early immobilization in compression fracture patients [11][12][13]. Michinari reported that hydroxyapatite was sufficient to replace bone defect owing to its chemical similarity to bone [14].…”

Section: Discussionmentioning

confidence: 99%

Monostotic fibrous dysplasia of the thoracic spine: A case report

Ren

Lan

Zheng

et al. 2016

BMR

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“…Radiographic findings include a matrix ‘ground-glass appearance’, areas of marginal sclerosis adjacent to lytic regions with a narrow transitional zone, and pathological fractures. A better needle biopsy of the lesion would have facilitated diagnosis 12. Generalised fibromatosis is part of the spectrum of fibromatoses in infancy and childhood.…”

Section: Discussionmentioning

confidence: 99%

A kind of specific osteolytic destruction of the vertebral bodies

Peng

Chen²,

Pang³

et al. 2012

BMJ Case Reports

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SummaryThis report describes two young patients with osteolytic destruction in two adjacent vertebral bodies along with the intervertebral disc, and reveals its possible mechanism. A lateral radiograph and CT scan displayed a giant osteolytic cavity in the L4 vertebral body. An MRI or CT scan with a two-dimensional reconstruction displayed the same changes in the L4 vertebral body and lower endplate erosion in the L3 vertebral body. A comprehensive preoperative evaluation did not identify a specific cause of vertebral destruction. Both patients underwent anterior lumbar fusion surgery. The lesions were removed for histological and immunohistochemical examination. Histopathological study of the destructed vertebral bodies in the two patients revealed the disruption or atrophy of bone trabeculae with infiltration of a large amount of B-lymphocytes and macrophages into the marrow cavities. Studies of its pathogenesis reveal that it is likely to be a B-lymphocyte-mediated local immune inflammatory reaction in the lumbar spine. BACKGROUND

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Polyostotic Fibrous Dysplasia of the Thoracic Spine

Abstract: Percutaneous kyphoplasty was a good therapeutic option for the reported patient.

Cited by 13 publications

References 27 publications

Monostotic fibrous dysplasia at C7 treated with vertebroplasty: a case report and review of the literature

Monostotic fibrous dysplasia at C7 treated with vertebroplasty: a case report and review of the literature

Monostotic fibrous dysplasia of the thoracic spine: A case report

A kind of specific osteolytic destruction of the vertebral bodies

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