2008
DOI: 10.1128/jvi.02650-07
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Polyomavirus Middle T Antigen Induces the Transcription of Osteopontin, a Gene Important for the Migration of Transformed Cells

Abstract: Middle T antigen (MT) is the principal oncoprotein of murine polyomavirus. Experiments on the acute immediate effects of MT expression on cellular RNA levels showed that expression of osteopontin (OPN) was strongly induced by MT expression. Osteopontin is a protein known to be associated with cancer. It has a role in tumor progression and invasion. Protein analysis confirmed that MT induced the secretion of OPN into the extracellular medium. Expression of antisense OPN RNA had no effect on the growth of MT-tra… Show more

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Cited by 13 publications
(11 citation statements)
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“…Comparison of a low metastasis mutant MT cell line to a highly metastatic one (Met) showed the Met line produced OPN and suppression of OPN blocked its metastasis [115]. Expression of OPN does not affect growth, but contributes to migration [115, 116]. MT regulates the OPN transcription through PEA3 sites [116].…”
Section: Metastasis In the Mmtv-mt Modelmentioning
confidence: 99%
See 1 more Smart Citation
“…Comparison of a low metastasis mutant MT cell line to a highly metastatic one (Met) showed the Met line produced OPN and suppression of OPN blocked its metastasis [115]. Expression of OPN does not affect growth, but contributes to migration [115, 116]. MT regulates the OPN transcription through PEA3 sites [116].…”
Section: Metastasis In the Mmtv-mt Modelmentioning
confidence: 99%
“…Expression of OPN does not affect growth, but contributes to migration [115, 116]. MT regulates the OPN transcription through PEA3 sites [116]. Thrombospondin-1 is a matricellular protein, which like OPN, is controlled by MT and appears to promote migration and metastasis.…”
Section: Metastasis In the Mmtv-mt Modelmentioning
confidence: 99%
“…This effectively creates a positive feedback loop. Indeed, the silencing of osteopontin in MT-transformed and tumor cell lines reduced their migration and metastatic potential (150,326). Other examples of known autocrine mammary growth factors whose expression increases gradually during MT tumor progression are amphiregulin and Cripto (209).…”
Section: The Widely Used Transgenic Mmtv-pymtmentioning
confidence: 99%
“…However, the expression of dominant negative Plc γ1 reduced metastasis, suggesting that 322 might play a role in that process (Shepard et al, 2007). Induction of metastasis seems to depend on the production of osteopontin (Jessen et al, 2004), which is regulated by MT at the transcriptional level through both Shc and PI3K (Whalen et al, 2008). A remaining question is whether MT is functioning as “one-hit” tumor inducer, or whether MT initiates a series of events that lead to other genetic changes required for tumor formation.…”
Section: Other Mt Binding Proteinsmentioning
confidence: 99%