Polyols and remineralisation of enamel subsurface lesions

Shen, Peiyan; Walker, G.; Yuan, Yue; Reynolds, Coralie; Reynolds, Eric C.

doi:10.1016/j.jdent.2017.08.008

Cited by 11 publications

(7 citation statements)

References 31 publications

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“…The evidence regarding whether xylitol promotes remineralization is equivocal. In 2 in vitro studies, one study result supports the remineralization capability of xylitol [Cardoso et al, 2014] while the other does not [Shen et al, 2017]. In the former study, the remineralization was observed in conjunction with fluoride plus xylitol.…”

Section: Discussionmentioning

confidence: 86%

Oral and Systemic Effects of Xylitol Consumption

Janket

Benwait

Isaac³

et al. 2019

Caries Res

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Section: Discussionmentioning

confidence: 86%

Oral and Systemic Effects of Xylitol Consumption

Janket

Benwait

Isaac³

et al. 2019

Caries Res

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“…The experimental varnishes may favor remineralization in deeper layers, either by decreasing the acidogenic potential of plaque or by facilitating the movement of Ca 2+ ions from the saliva towards enamel. 6,11,28 The cross-sectional hardness and integrated area under the curve (calculated by the trapezoidal rule) were calculated to show the integrated loss of subsurface hardness (ΔKHN) 25 for both arms of this study and transverse microradiography was also evaluated for the in situ arm. Ideally, both methods, hardness and transverse microradiography, should be combined, as hardness does not necessarily measure the mineral content and some studies regarding the conversion of hardness to mineral volume are controversial.…”

Section: Discussionmentioning

confidence: 99%

Effect of xylitol varnishes on enamel remineralization of immature teeth: in vitro and in situ studies

et al. 2021

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We evaluated the efficacy of xylitol varnishes on the remineralization of newly erupted permanent and deciduous teeth in vitro and in situ. Human enamel specimens were randomly allocated to 8 groups (n = 15/group). Artificial caries lesions were produced and enamel alterations were quantified by surface/subsurface hardness and transverse microradiography. The blocks were then treated with the following varnishes: Duraphat TM ; 20 wt% xylitol (146 μm) varnish; 20 wt% milled xylitol (80 μm) varnish, and placebo varnish, and removed after 6 h of immersion in artificial saliva. In vitro: the blocks were subjected to pH-cycles for 8 days. In situ: fifteen subjects wore palatal appliances containing four pre-demineralized and treated enamel specimens, for 5 days. Data were statistically analyzed by ANOVA/ Tukey and Kruskal-Wallis/Tukey's test (p < 0.05). The %SHR in both studies was significantly increased by xylitol and Duraphat™ varnishes when compared to placebo. Considering subsurface remineralization, only the xylitol varnishes were able to significantly reduce the enamel lesion. Xylitol varnishes can be promising alternatives to promote enamel remineralization of newly erupted permanent and deciduous teeth.

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“…The teeth were sterilised by storage for at least 14 days in 10% ( v / v ) neutral buffered formalin solution at room temperature. Enamel slabs were cut from the sterilised teeth and subsurface lesions were created as previously described [ 29 ]. This involved painting the enamel slabs with acid-resistant nail varnish (Red 745, Revlon, Oxford, NC, USA) to expose two windows (1 × 7 mm) of enamel on each slab that were demineralised for four days at 37 °C using a demineralisation buffer to produce subsurface lesions of approximately 100 μm depth [ 29 ].…”

Section: Methodsmentioning

confidence: 99%

“…Enamel slabs were cut from the sterilised teeth and subsurface lesions were created as previously described [ 29 ]. This involved painting the enamel slabs with acid-resistant nail varnish (Red 745, Revlon, Oxford, NC, USA) to expose two windows (1 × 7 mm) of enamel on each slab that were demineralised for four days at 37 °C using a demineralisation buffer to produce subsurface lesions of approximately 100 μm depth [ 29 ]. The composition of the demineralisation buffer was 80 mL/L Goodrite K-702 polyacrylate (Lubrizol Advanced Materials Inc., Cleveland OH, USA), 500 mg/L hydroxyapatite (Bio-Gel HTP, Bio-Rad Laboratories, Hercules, CA, USA), and 0.1 M lactic acid (Ajax Chemical, Mt Pritchard, NSW, Australia), adjusted to pH 4.8.…”

Section: Methodsmentioning

confidence: 99%

Comparative Efficacy of Novel Biomimetic Remineralising Technologies

et al. 2023

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Biomimetic technologies for the remineralisation of enamel subsurface lesions (ESLs) have been developed and include: fluorocalcium phosphosilicate bioglass (BG/F); casein phosphopeptide-amorphous calcium phosphate (CPP–ACP) and with fluoride (CPP–ACFP); and self-assembling oligopeptide P11-4 (SAP). The aim of this study was to compare the remineralisation of ESLs in vitro using these technologies. Human enamel slabs with ESLs were cut into two half-slabs; one half-slab was untreated (control), and the other half was treated by exposure to one of the four technologies with artificial saliva (AS) or AS alone for 14 days at 37 °C. The technologies were applied to the ESL surface according to the manufacturer’s instructions. At the completion of each treatment, the treated half-slabs and their paired control half-slabs were embedded, sectioned and the mineral content was determined using transverse microradiography. The change in mineral content (remineralisation) between treatments was statistically analysed using one-way ANOVA. The order from highest to lowest remineralisation was CPP–ACFP (52.6 ± 2.6%) > CPP–ACP (43.0 ± 4.9%) > BG/F (13.2 ± 2.5%) > SAP (5.8 ± 1.6%) > AS (2.1 ± 0.5%). Only CPP–ACFP and CPP–ACP produced remineralisation throughout the body of the lesions. All four biomimetic technologies had some effect on the remineralisation of ESLs; however, CPP–ACFP with calcium, phosphate and fluoride ions stabilised by CPP was superior in the level and pattern of remineralisation obtained.

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Polyols and remineralisation of enamel subsurface lesions

Abstract: This controlled in vitro study showed that polyols at physiologically relevant concentrations did not promote remineralisation of enamel subsurface lesions by facilitating calcium uptake into the lesion.

Cited by 11 publications

References 31 publications

Oral and Systemic Effects of Xylitol Consumption

Oral and Systemic Effects of Xylitol Consumption

Effect of xylitol varnishes on enamel remineralization of immature teeth: in vitro and in situ studies

Comparative Efficacy of Novel Biomimetic Remineralising Technologies

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