Polynuclear complex formation in solutions of calcium ion and 1-hydroxyethylene-1,1-diphosphonic acid. I. Complexometric and pH titrations

Synthesis and Aggregation Properties of Salts Based on Aminomethylated Calix[4]resorcinols and 1-Aminoethylidenediphosphonic Acid

“…Elemental analyzes were performed on a Carlo Erba elemental analyzer EA 1108. 4,6,10,12,16,18,22,11,17, 3,7 .1 9,13 .1 15,19 ]octacosa-1(25),3,5,7(28), 9,11,13(27) Purified water (18.2 MΩ cm resistivity at 25 0 C) from Direct-Q 5 UV equipment was used for all solution preparation.…”

“…[14] Currently, there is growing interest in obtaining salts of organic molecules based on bisphosphonic acids. [15,16] The ability of these low-toxicity acids to form gels, as well as stable complexes with metals [17][18][19] allows their using as components of supramolecular gels. [20] In addition, bisphosphonates are recognized as an important class of drugs for the treatment of various diseases associated with excessive bone resorption, including Paget's disease, [21] bone metastases and osteoporosis.…”

Efficacy of topical risedronate and risedronate - Eudragit E complex in a model of cutaneous leishmaniasis induced by Leishmania (Leishmania) amazonensis

“…In order to verify this, in vitro studies should be performed. Unfortunately, we were unsuccessful in performing in vitro studies due to the insolubility of Ris and EuE-Ris in culture media since aminobisphosphonates form insoluble complexes with calcium or other divalent cations [14,35] and EuE precipitates at pH values above 5 [36].…”

Interactions between Clinically Used Bisphosphonates and Bone Mineral: from Coordination Chemistry to Biomedical Applications and Beyond

“…However, only few of them focus on clinically relevant BPs . Within this group, the greatest number of studies have been devoted to etidronate and clodronate . Others, such as pamidronate, alendronate, tiludronate, or zolendronate have been discussed in only a few research papers.…”