Polynorbornene-derived block copolymer micelles via ring‐opening metathesis polymerization with capacity of hydrogen sulfide generation

Le, Trong‐Nghia; Huang, Ru; Lee, Cheng‐Kang; Rao, N. Vijayakameswara

doi:10.1016/j.eurpolymj.2022.111294

Cited by 3 publications

(1 citation statement)

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“…The application of the polymersomes in combination with a cysteine solution onto infected diabetic wounds facilitated wound healing and inhibited bacterial growth. Lao and coworkers synthesized amphiphilic block copolymers using SATO‐ and PEG‐conjugated norbornene monomers via ring‐opening metathesis polymerization (Le et al, 2022). The micelles prepared from the polymers protected mouse fibroblast L929 cells from oxidative damage induced by H 2 O 2 .…”

Section: Self‐assembled Polymeric Gas Donorsmentioning

confidence: 99%

Recent advance in self‐assembled polymeric nanomedicines for gaseous signaling molecule delivery

van der Vlies,

Yamane,

Hasegawa

2023

WIREs Nanomed Nanobiotechnol

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Gaseous signaling molecules such as nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) have recently been recognized as essential signal mediators that regulate diverse physiological and pathological processes in the human body. With the evolution of gaseous signaling molecule biology, their therapeutic applications have attracted growing attention. One of the challenges in translational research of gaseous signaling molecules is the lack of efficient and safe delivery systems. To tackle this issue, researchers developed a library of gas donors, which are low molecular weight compounds that can release gaseous signaling molecules upon decomposition under physiological conditions. Despite the significant efforts to control gaseous signaling molecule release from gas donors, the therapeutic potential of gaseous signaling molecules cannot be fully explored due to their unfavorable pharmacokinetics and toxic side effects. Recently, the use of nanoparticle‐based gas donors, especially self‐assembled polymeric gas donors, have emerged as a promising approach. In this review, we describe the development of conventional small gas donors and the challenges in their therapeutic applications. We then illustrate the concepts and critical aspects for designing self‐assembled polymeric gas donors and discuss the advantages of this approach in gasotransmistter delivery. We also highlight recent efforts to develop the delivery systems for those molecules based on self‐assembled polymeric nanostructures.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Section: Self‐assembled Polymeric Gas Donorsmentioning

confidence: 99%