Polyneuropathy in Severely Obese Women Without Diabetes: Prevalence and Associated Factors

Dias, Lisiane Stefani; Nienov, Otto Henrique; Machado, Fernanda Dapper; Ramos, Camila Perlin; Rodrigues, Daiane; Menguer, Rodrigo Koprovsky; Schmid, Helena

doi:10.1007/s11695-018-03627-0

Cited by 6 publications

(2 citation statements)

References 22 publications

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“…Menopause marks the end of the reproductive phase of a woman's life, following a reduction in estrogen levels 54 . Postmenopausal status increases the risk of peripheral nerve disorders in non-diabetic obese women 16 . The age at menopause, total reproductive lifespan, and time since menopause were considered in this study.…”

Section: Discussionmentioning

confidence: 99%

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Association of reproductive factors and exogenous hormone use with distal sensory polyneuropathy among postmenopausal women in the United States: results from 1999 to 2004 NHANES

Chongpison

Amornvit

et al. 2023

Sci Rep

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Postmenopausal status is a risk factor for distal sensory polyneuropathy—the most common type of peripheral neuropathy. We aimed to investigate associations between reproductive factors and history of exogenous hormone use with distal sensory polyneuropathy among postmenopausal women in the United States using data from the National Health and Nutrition Examination Survey 1999–2004, and to explore the modifying effects of ethnicity on these associations. We conducted a cross-sectional study among postmenopausal women aged ≥ 40 years. Women with a history of diabetes, stroke, cancer, cardiovascular disease, thyroid disease, liver disease, weak or failing kidneys, or amputation were excluded. Distal sensory polyneuropathy was measured using a 10-g monofilament test, and a questionnaire was used to collect data on reproductive history. Multivariable survey logistic regression was used to test the association between reproductive history variables and distal sensory polyneuropathy. In total, 1144 postmenopausal women aged ≥ 40 years were included. The adjusted odds ratios were 8.13 [95% confidence interval (CI) 1.24–53.28] and 3.18 (95% CI 1.32–7.68) for age at menarche < 11 years and time since menopause > 20 years, respectively, which were positively associated with distal sensory polyneuropathy; adjusted odds ratios were 0.45 for the history of breastfeeding (95% CI 0.21–0.99) and 0.41 for exogenous hormone use (95% CI 0.19–0.87) were negatively associated. Subgroup analysis revealed ethnicity-based heterogeneity in these associations. Age at menarche, time since menopause, breastfeeding, and exogenous hormone use were associated with distal sensory polyneuropathy. Ethnicity significantly modified these associations.

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Section: Discussionmentioning

confidence: 99%

“…Women undergo menopause around this age, ending their reproductive phase 15 . Postmenopausal status has consistently been a risk factor for polyneuropathy in non-diabetic obese individuals 16 . Peripheral neuropathy always coexists with central nervous system diseases 17 , 18 .…”

Section: Introductionmentioning

confidence: 99%