Polyneuropathy and the sural/radial sensory nerve action potential ratio in primary Sjögren’s syndrome

Primary Sjögren syndrome‐related peripheral neuropathy: A systematic review and meta‐analysis

“…The study selection process is illustrated in the PRISMA chart (Figure 1). All of the 49 studies that met our inclusion criteria [19–67] were of an observational nature. The majority of the papers were published by research teams that included both rheumatologists/internists and neurologists ( n = 31) followed by research teams that included either only rheumatologists/internists ( n = 12) or only neurologists ( n = 6).…”

“…The study selection process is illustrated in the PRISMA chart (Figure 1 ). All of the 49 studies that met our inclusion criteria [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 ] were of an observational nature. The majority of the papers were published by research teams that included both rheumatologists/internists and neurologists ( n = 31) followed by research teams that included either only rheumatologists/internists ( n = 12) or only neurologists ( n = 6).…”

“…Figure 2 shows the pooled prevalence of large fiber PN in nonselected populations of patients with pSS, following the meta‐analysis of 29 available studies [ 20 , 21 , 22 , 23 , 25 , 26 , 27 , 28 , 30 , 31 , 32 , 35 , 36 , 40 , 41 , 42 , 45 , 46 , 48 , 50 , 52 , 54 , 56 , 57 , 58 , 59 , 61 , 63 , 66 ] assessing a total of 4874 patients. The pooled prevalence was 15.0% (95% confidence interval [CI] = 10.7%–20.7%).…”

“…Figure 3 shows the pooled prevalence of peripheral mononeuropathies, all concerning entrapment of the median nerve at the wrist (carpal tunnel syndrome) in nonselected populations of patients with pSS, following the meta‐analysis of 11 available studies [ 23 , 25 , 30 , 31 , 32 , 35 , 46 , 52 , 59 , 61 , 63 ] assessing a total of 733 patients. The pooled prevalence was 12.8% (95% CI = 7.2%–21.8%).…”

“…The majority of cranial mononeuropathies in pSS patients involve the trigeminal nerve. As shown in Figure 5 , the pooled prevalence of trigeminal neuropathy following the meta‐analysis of 10 available studies [ 22 , 23 , 25 , 30 , 35 , 36 , 42 , 54 , 57 , 63 ], assessing a total of 935 patients, was 3.9% (95% CI = 2.2%–6.9%). However, there was high heterogeneity across the included studies ( I 2 = 52%).…”