Polyneuropathies and CNS Protein Metabolism

Schotman, P.; Gipon, L.; Jennekens, F. G. I.; Gispen, Willem Hendrik

doi:10.1097/00005072-197811000-00008

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1982

1988

Publication Types

Select...

Article3

Book2

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 33 publications

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Acrylamide neuropathy and changes in the axonal transport and muscular content of the molecular forms of acetylcholinesterase

et al. 1982

View full text Add to dashboard Cite

Acetylcholinesterase (AChE) is present in nervous and muscular tissues of normal chickens in four main molecular forms (G1, G2, G4, and A12), distinguishable by sedimentation analysis. In the sciatic nerve of acrylamide-poisoned chickens, the anterograde axonal transport of A12 AChE was reduced by 60%, and that of G4 by 21%, compared to control values whereas the slow axoplasmic transport of G1 and G2 was unaffected. Regarding the leg muscles, only the tibialis anterior revealed dramatic alterations in the distribution of it AChE forms coinciding with a large reduction in the number of nerve endings. In acrylamide poisoning, the AChE molecular forms were considered as very sensitive markers of both axonal transport phases and of the innervation state. Our results support the hypothesis that a defect in the fast axonal transport of proteins might be involved in the degeneration process of the disease.

show abstract