Polyneuritis cranialis associated with industrial trichloroethylene poisoning.

Buxton, P. H.; Hayward, Michael A.

doi:10.1136/jnnp.30.6.511

Cited by 100 publications

(36 citation statements)

References 19 publications

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“…In an acute phase in which insulin levels were significantly raised in men during the initial exposure period, the mean level of 40.8 mIU/l was about fourfold the mean in normal nonexposed men (9.6 mIU/l), and levels were lowest in the 2-4 year exposure group. In groups exposed to TCE for more than 4 years, insulin levels gradually increased; in the >6-year exposure group, insulin levels were within normal range.…”

Section: Discussionmentioning

confidence: 97%

Effects of Chronic Exposure to Low Doses of Trichloroethylene on Steroid Hormone and Insulin Levels in Normal Men

Goh¹,

Chia²,

Ong³

1998

Environmental Health Perspectives

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The aim ofdis studywas to exmine the senum leves ofinsulin and some adrena steroid hormones in men c expbosd toXlow doe of tricooety e (TCE). A tiotal of 85 workers participated in tis study Each worker had urine collected and analyze for trichioroacetic adds (UTCA) on the same day that a blood sample was taken for analyses of serum rone, hormOnebinding globulin (SHBG), androstenedione, cortisol, d rone, and insulin. lle mean concentraion of e UTCA was 22.4 pmg a creanTnine (rnge 0.8-136.4 (1) indicated that exposure to TCE in excess of national norms can cause ill effects induding speech and hearing impairments, effects of stroke, liver problems, anemia and other blood disorders, diabetes, kidney disease, urinary tract disorders, and skin rashes. However, relatively few studies have evaluated the long-term effects of exposure to TCE at levels below the threshold limit value (TLV) (2-6).In two early publications, we showed that long-term exposure to TCE at levels below the TLV was not associated with any significant changes in levels of reproductive hormone or spermatogenesis and semen quality (7,8). In this paper, we present the effects of long-term exposure to TCE on insulin and adrenal hormones and discuss their associations with sex hormone-binding globulin (SHBG) and testsosterone (T) levels. Materials and MethodsDetails of recruitment and profiles of subjects involved in the study, as well as the experimental design, were reported earlier (8). The study population consisted of 85 male workers of Chinese descent who worked in an electronic fictory where TCE was used as a degreaser to dean small metal parts. Informed consent was obtained from each subject.In all 85 subjects ranging from 22 to 39 years of age, there were no factors in their medical histories that would influence the endocrine functions, e.g., no history of diabetes mellitus, long-term medication, or testicular injury. No abnormalities were detected clinically. All subjects had normal liver function tests (serum glutamic oxalacetic transaminase, serum glutamic pyruvic transaminase, gamma glutamyl transpeptidase, and alkaline phosphatase).Blood colection and hormonal assay. A single venous blood sample was collected between 7:30 and 8:00 A.M. from each subject throughout the study to reduce the diurnal variation of the hormonal levels.Sera were separated and stored at -700C until assayed.Serum concentrations of testosterone, androstenedione (A4), cortisol, aldosterone, insulin, and SHBG were measured by established immunoassays. Testosterone and cortisol were measured using the World Health Organization (WHO) matched reagents and methods (9). The intra-and interassay coefficients of variation of the assays were less than 10% over the effective concentration ranges.Serum levels of SHBG and aldosterone were measured using radioimmunoassay kits purchased from DPC Inc. (Los Angeles, CA). The intra-and interassay coefficients of variation were less than 15%. Serum insulin levels were measured using kits from CIS Bio International (Yvette, Cedex,...

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Section: Discussionmentioning

confidence: 97%

Effects of Chronic Exposure to Low Doses of Trichloroethylene on Steroid Hormone and Insulin Levels in Normal Men

Goh¹,

Chia²,

Ong³

1998

Environmental Health Perspectives

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“…Trichloroethylene or some of its breakdown products have caused cranial polyneuropathy, most marked in the fifth cranial nerve, in workers in industry (7,44,70). Similar case reports have appeared earlier in connection with general anesthesia of trichloroethylene and soda lime in a closed circuit as cited by Buxton and Hay-10 ward (7).…”

Section: Cal'bon Disulfidementioning

confidence: 99%

Applications of neurophysiological methods in occupational medicine. A review.

Am¹

1975

Scand J Work Environ Health

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“…Cases of central vestibular involvement have also been described. Reported sequelae of acute poisoning include headaches, amnesia, psychosis, limb weakness and hemiparesis [3][4][5] . Chronic exposure may lead to diffuse cerebral damage which manifests as headaches, asthenia, anorexia, vertigo, severe memory loss, depression, emotional disorders and, in more serious cases, clinical manifestations compatible with dementia 6) .…”

Section: Discussionmentioning

confidence: 99%