Polymyxin B and Doxycycline for Treatment of Multidrug Resistant Klebsiella Pneumoniae and Staphylococcus Aureus Pneumonia in Intensive Care Unit

Keyal, Niraj Kumar; Nakarmi, Manish; Adhikari, Pooja

doi:10.3126/bjhs.v4i2.25462

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“…Gram nega ve infec on is more common in developing country [10] ICU and incidence ranges from 47 to 84%. [10] Acinetobacter baumanniiis a MDR bacteria and incidence ranges from 13 to 41% [11][12][13] and mortality is very high up [11][12][13] to 81%.…”

Section: Discussionmentioning

confidence: 99%

Trimethoprim - Sulfamethoxazole in Combination With Meropenem Orpolymyxin is Effective in Management of Acinetobacter Baumannii Associated Pneumonia and Urinary Tract Infection

Keyal¹,

Nepal²,

Bhujel³

2020

Birat J. Health Sci.

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Acinetobacter baumanniiis a common multidrug resistant bacteria that causes pneumonia and urinary tract infection in intensive care unit and requires dual antibiotic for effective management. There are limited expensive antibiotics that are active against. Acinetobacter baumannii. Trimethoprim - Sulfamethoxazole is a cheap, older and easily available antibiotic that can be used in combination with Meropenem or Polymyxin for treatment to decrease antibiotic resistance. This case presentation of three patients describes the successful treatment of hospital acquired Pneumonia and Urinary Tract Infection by Acinetobacter baumannii with Trimethoprim - Sulfamethoxazole in combination with Meropenem and Polymyxin that lead avoidance of costly drugs and decrease in antibiotic resistance. Antibiotic resistance and lack of newer effective antibiotic against multidrug resistant bacteria like Acinetobacter baumannii is a common problem in intensive care unit. Trimethoprim -Sulfamethoxazole may help in combating this problem.

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