Polymyositis with antisynthetase syndrome presented with lobular panniculitis: A case report

Rungcharunthanakul, Amornrat; Sampattavanich, Nattaporn

doi:10.1002/ccr3.1839

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…Other than the classic features mentioned above, calcinosis, panniculitis, coronary artery dilatation, eosinophilic pleural effusions, and myopericarditis have also been reported in small case series. [60][61][62][63][64][65][66][67][68][69]…”

Section: Other Accompanying Featuresmentioning

confidence: 99%

Antisynthetase syndrome: A distinct disease spectrum

Huang

Aggarwal

2020

Journal of Scleroderma and Related Disorders

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The discovery of novel autoantibodies related to idiopathic inflammatory myopathies (collectively referred to as myositis) has not only advanced our understanding of the clinical, serological, and pathological correlation in the disease spectrum but also played a role in guiding management and prognosis. One group of the myositis-specific autoantibodies is anti-aminoacyl-tRNA synthetase (anti-ARS or anti-synthetase) which defines a syndrome with predominant interstitial lung disease, arthritis, and myositis. Autoantibodies to eight aminoacyl-tRNA synthetases have been identified with anti-Jo1 the most common in all of idiopathic inflammatory myopathies. Disease presentation and prognosis vary depending on which anti-aminoacyl-tRNA synthetase antibody is present. In this review, we will discuss the clinical characteristics, overlap features with other autoimmune diseases, prognostic factors, and management of the antisynthetase syndrome.

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Section: Other Accompanying Featuresmentioning

confidence: 99%

Antisynthetase syndrome: A distinct disease spectrum

Huang

Aggarwal

2020

Journal of Scleroderma and Related Disorders

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“…Several case reports have published diverse clinical findings such as calcinosis, panniculitis, and myopericarditis 54–56 …”

Section: Introductionmentioning

confidence: 99%

Anti‐Jo1 autoantibodies, from clinic to the bench

Galindo-Feria

Horuluoglu

Lundberg

2022

Rheumatology & Autoimmunity

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Introduction Idiopathic inflammatory myopathies (IIM) also known as myositis, is a chronic autoimmune disease which affects muscles, skin, joints and lung. One of the most common autoantibodies with a prevalence of 25‐35%, is the anti‐Jo‐1 autoantibodies, targeting the histidyl‐transfer RNA synthetase (HisRS). These autoantibodies are strongly associated with a distinct clinical phenotype called anti‐synthetase syndrome (ASyS) that includes interstitial lung disease (ILD), myositis, arthritis and Raynaud's phenomenon. The mechanism of how autoantibodies are produced and how they contribute to disease pathogenesis is unclear. Areas Covered In this review we will discuss the clinical manifestations associated with Jo‐1 autoantibodies, and the association with clinical features. Moreover, we will also review the molecular characteristics of the antibodies and how they affect the cells of the immune system in order to understand possible disease mechanisms.

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“…Cutaneous manifestations are uncommon but may include dermatomyositis (DM)-related eruptions. To our knowledge, panniculitis has only been reported in 1 study preceding ASyS onset . Herein, we describe an atypical presentation of refractory ASyS initially mimicking angioedema and subsequently diffuse panniculitis and cutaneous ulcers that, along with arthritis, improved on ruxolitinib initiation.…”

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confidence: 99%