Polymyositis associated with primary biliary cirrhosis

Boki, Kyriaki; Dourakis, Spyridon P.

doi:10.1007/bf02208358

Cited by 16 publications

(4 citation statements)

References 9 publications

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“…AMAs, as biomarkers of PBC, have been reported in several case reports and cohorts in IIM [14][15][16][17]. Therefore, AMAs are identi ed as MRAs.…”

Section: Discussionmentioning

confidence: 99%

Muscle pathological features and extra-muscle involvement in idiopathic inflammatory myopathies with anti-mitochondrial antibody

Zhang

Yang

Lei

et al. 2021

Seminars in Arthritis and Rheumatism

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BackgroudAnti-mitochondrial antibodies (AMAs) can be detected in some idiopathic in ammatory myopathy (IIM) patients. We aimed to investigate the clinical features of IIM patients with AMAs. MethodsWe retrospectively analysed consecutive 1,167 patients with IIM for AMAs-associated myositis and compared them to age-and sex-matched AMA-negative patients. ResultsTwenty-nine patients (2.5%) were identi ed with AMAs-positive myositis; eight of them had primary biliary cholangitis (PBC). There were no signi cant differences in skin rash, dysphagia, interstitial lung disease, and muscle strength between AMAs-positive patients and disease controls. 12/23(52.2%) cases showed immune-mediated necrotizing myopathy (IMNM)-like pathological features. Among AMAs-positive patients, 11 of 16 patients with isolated anti-AMA were classi ed as IMNM which was signi cantly higher than that of patients with coexistent anti-AMAs and myositis-speci c antibodies (p=0.026). Moreover, AMAs-positive patients had a signi cantly higher cardiac involvement ratio (P<0.001) compared to controls. Comparsion in AMAs-positive IIM patients show the incidence of abnormal echocardiography ndings was signi cantly higher in patients without primary biliary cholangitis (PBC) than in patients with PBC(P=0.009). Patients without heart abnormalities took signi cantly less time to achieve disease remission and prednisone tapering to <10 mg than patients with heart abnormalities (P<0.001 and P=0.001, respectively). ConclusionsIMNM was a major histopathological nding in IIM patients with isolated anti-AMAs antibody. AMAs was signi cantly associated with cardiac involvement in IIM. PBC seemed to be a protective factor for abnormal echocardiography ndings in AMAs-positive patients. Patients without heart involvement took less time to achieve disease remission and prednisone tapering off.

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“…AMAs, as biomarkers of PBC, have been reported in several case reports and cohorts in IIM [14][15][16][17]. Therefore, AMAs are identi ed as MRAs.…”

Section: Discussionmentioning

confidence: 99%

Muscle pathological features and extra-muscle involvement in idiopathic inflammatory myopathies with anti-mitochondrial antibody

Zhang

Yang

Lei

et al. 2021

Seminars in Arthritis and Rheumatism

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“…1,10 Unusual PBC associations have occasionally been reported, with interstitial lung disease, 11 ulcerative colitis 12 IgM-associated membranous glomerular nephritis, 13 celiac disease, 14 autoimmune thrombocytopenia, 15 and polymyositis. 16 Although the association between various immunologic disorders and PBC has gradually been gaining recognition, only ten cases of PBC associated with AIHA have been reported. [17][18][19][20][21][22][23][24][25][26] AIHA is characterized by a positive direct Coombs' test and is classified as 'warm' or 'cold' type, according to whether the antibody reacts better with red cells at 37°C or at 4°C.…”

Section: Discussionmentioning

confidence: 99%

A patient with primary biliary cirrhosis associated with autoimmune hemolytic anemia

Nakasone

Sakugawa

Fukuchi

et al. 2000

Journal of Gastroenterology

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“…Muscular involvement has also rarely been reported in patients with PBC and these cases were generally polymyositis [9] . A few cases with myopathy but no evidence of inflammation have been reported, however, unlike the present case, these cases had severe progressive myopathy with cardiac involvement and grave prognosis [10] .…”

Section: Discussionmentioning

confidence: 99%

Osteomalacic Myopathy Associated with Coexisting Coeliac Disease and Primary Biliary Cirrhosis

Demirağ

Göker²,

Haznedaroğlu³

et al. 2008

Med Princ Pract

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Objective: To report a patient with coeliac disease (CD) associated with primary biliary cirrhosis (PBC) who presented with myopathy without classical symptoms of CD. Clinical Presentation and Intervention: A 42-year-old woman presented with inability to walk and marked loss of motor function. She had elevated liver enzymes with a cholestatic pattern. Antimitochondrial antibody M2 band, anti-endomysial antibody, antigliadin IgA and IgM were positive. Histopathologic findings of the liver revealed PBC and duodenal biopsy was consistent with CD. She was also found to have osteomalacia. She showed slow response to gluten-free diet, but accelerated full recovery with vitamin D replacement. Conclusion: In PBC patients with subclinical CD and myopathy, vitamin D status can provide a basis for treatment.

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Polymyositis associated with primary biliary cirrhosis

Cited by 16 publications

References 9 publications

Muscle pathological features and extra-muscle involvement in idiopathic inflammatory myopathies with anti-mitochondrial antibody

Muscle pathological features and extra-muscle involvement in idiopathic inflammatory myopathies with anti-mitochondrial antibody

A patient with primary biliary cirrhosis associated with autoimmune hemolytic anemia

Osteomalacic Myopathy Associated with Coexisting Coeliac Disease and Primary Biliary Cirrhosis

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