Polymyositis and dermatomyositis

Lundberg, IE; Cooper, RG; Chinoy, Hector

doi:10.1093/med/9780199642489.003.0124_update_001

Cited by 5 publications

(4 citation statements)

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“…Idiopathic inflammatory myopathies (IIMs) are chronic multisystem autoimmune conditions that may cause muscle inflammation (myositis), skin manifestations and interstitial lung disease (ILD) [ 1 , 2 ]. Adult-onset IIMs are associated with increased risk of cancer.…”

Section: Introductionmentioning

confidence: 99%

A systematic review and meta-analysis to inform cancer screening guidelines in idiopathic inflammatory myopathies

et al. 2021

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Objectives To identify clinical factors associated with cancer risk in the idiopathic inflammatory myopathies (IIMs) and to systematically review the existing evidence related to cancer screening. Methods A systematic literature search was carried out on Medline, Embase and Scopus. Cancer risk within the IIM population (i.e. not compared to the general population) was expressed as risk ratios (RR) for binary variables and weighted mean differences (WMD) for continuous variables. Evidence relating to cancer screening practices in the IIMs were synthesised via narrative review. Results Sixty nine studies were included in the meta-analysis. Dermatomyositis subtype (RR 2.21), older age (WMD 11.19), male gender (RR 1.53), dysphagia (RR 2.09), cutaneous ulceration (RR 2.73), and anti-transcriptional intermediary factor-1 gamma positivity (RR 4.66) were identified as being associated with significantly increased risk of cancer. Polymyositis (RR 0.49) and clinically amyopathic dermatomyositis (RR 0.44) subtypes, Raynaud’s phenomenon (RR 0.61), interstitial lung disease (RR 0.49), very high serum creatine kinase (WMD -1189.96) or lactate dehydrogenase (WMD -336.52) levels, and anti-Jo1 (RR 0.45) or anti-EJ (RR 0.17) positivity were identified as being associated with significantly reduced risk of cancer. Nine studies relating to IIM-specific cancer screening were included. Computed tomography (CT) scanning of the thorax, abdomen and pelvis appeared to be effective in identifying underlying asymptomatic cancers. Discussion Cancer risk factors should be evaluated in patients with IIM for risk stratification. Screening evidence is limited but CT scanning could be useful. Prospective studies and consensus guidelines are needed to establish cancer screening strategies in IIM patients.

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Section: Introductionmentioning

confidence: 99%

A systematic review and meta-analysis to inform cancer screening guidelines in idiopathic inflammatory myopathies

et al. 2021

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“…Idiopathic inflammatory myopathy (IIM, commonly termed 'myositis') is a chronic multisystem autoimmune condition with a range of manifestations, including muscle inflammation, skin involvement and interstitial lung disease 1,2 . Adult-onset IIM is associated with an increased risk of cancer, particularly within the 3 years prior to and the 3 years after IIM onset 3 .…”

Section: Introductionmentioning

confidence: 99%

International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative

Oldroyd,

Callen,

Chinoy

et al. 2023

Nat Rev Rheumatol

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Adult-onset idiopathic inflammatory myopathy (IIM) is associated with an increased cancer risk within the 3 years preceding and following IIM onset. Evidence-and consensus-based recommendations for IIM-associated cancer screening can potentially improve outcomes. This International Guideline for IIM-Associated Cancer Screening provides recommendations addressing IIM-associated cancer risk stratification, cancer screening modalities and screening frequency. The international Expert Group formed a total of 18 recommendations via a modified Delphi approach using a series of online surveys. First, the recommendations enable an individual patient's IIM-associated cancer risk to be stratified into standard, moderate or high risk according to the IIM subtype, autoantibody status and clinical features. Second, the recommendations outline a 'basic' screening panel (including chest radiography and preliminary laboratory tests) and an 'enhanced' screening panel (including CT and tumour markers). Third, the recommendations advise on the timing and frequency of screening via basic and enhanced panels, according to risk status. The recommendations also advise consideration of upper or lower gastrointestinal endoscopy, nasoendoscopy and 18 F-FDG PET-CT scanning in specific patient populations. These recommendations are aimed at facilitating earlier IIM-associated cancer detection, especially in those who are at a high risk, thus potentially improving outcomes, including survival.Sections feedback on the acceptability of the final recommendations and co-authored the final manuscript, although they were not involved in the voting process (one patient partner chose to remain anonymous and not be included as a co-author).The project and final manuscript were reviewed and approved by the IMACS Scientific Committee.Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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“…Erkek cinsiyet, hastalığın ortaya çıkış yaşı, kas veya deride daha ağır tutulum, artmış eritrosit sedimantasyon hızı (ESH) ve CRP değerleri, düşük albümin, miyozit antikorlarında negativite ve pozitif 155/140 antikoru risk faktörleri arasındadır (6).…”

Section: Discussionunclassified

Dermatomiyozit ve malignite birlikteliği: bir olgu örneği

et al. 2019

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Dermatomiyozit, hem kas, hem de derinin tutulduğu bir sistemik otoimmün hastalıktır. Hastaların önemli bir kısmında altta bir malignite varlığı tespit edilebilmektedir. Birliktelik genellikle solid organ tümörleri olmakla beraber birçok malign neoplazi ile ilişkili olabilir. Bu nedenle hastalarda sadece hastalık yönetiminin gerçekleştirilmesi değil, sistemik açıdan da detaylı bir şekilde taranması ve gelecekte de bu açıdan izlenmesi önemlidir. Sunulacak olgu bahsettiğimiz birlikteliğe bir örnek teşkil etmektedir.

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Polymyositis and dermatomyositis

Cited by 5 publications

References 0 publications

A systematic review and meta-analysis to inform cancer screening guidelines in idiopathic inflammatory myopathies

A systematic review and meta-analysis to inform cancer screening guidelines in idiopathic inflammatory myopathies

International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative

Dermatomiyozit ve malignite birlikteliği: bir olgu örneği

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