Polymyalgia rheumatica and primary biliary cirrhosis.

Robertson, James; Batstone, G.F.; Loebl, W Y

doi:10.1136/bmj.2.6145.1128

Cited by 17 publications

(3 citation statements)

References 3 publications

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“…Elevated levels of alkaline phosphatase, 1–4 5′‐nucleotidase, 2 and alanine aminotransferase, 3 prolonged prothrombin time, 3 and reduced excretion of sulfobromophthalein (Bromsulphalein,® BSP) have been reported. Varied histologic findings have been reported on liver biopsy, ranging from normal, 3 to fatty changes, 3 , 8 portal tract infiltration by lymphocytes and monocytes, 4 bile canalicular stasis, 10 primary biliary cirrhosis, 11 chronic hepatitis, 12 and finally (very infrequently), to granuloma 5–9 . This appears to be the first case of PMR associated with granulomatous hepatitis that has been reported in Israel.…”

Section: Discussionmentioning

confidence: 75%

Hepatic Granuloma in Polymyalgia Rheumatica

Burke

Sasson

Baratz

et al. 1984

J American Geriatrics Society

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Hepatic granuloma occurs rarely in the polymyalgia rheumatica syndrome. A case was presented of a 62-year-old woman with polymyalgia rheumatica, elevated concentrations of hepatic enzymes, and granuloma of the liver. Low doses of corticosteroids produced a marked improvement in the patient's condition and a return of liver function tests to normal. This is apparently the first case of polymyalgia rheumatica associated with liver granuloma that has been reported in Israel.

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Section: Discussionmentioning

confidence: 75%

Hepatic Granuloma in Polymyalgia Rheumatica

Burke

Sasson

Baratz

et al. 1984

J American Geriatrics Society

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“…The possibility that GCs can realize a confounding factor should be considered. Indeed, abnormal liver function tests typically normalize after GC therapy [ 17 ], and this can delay diagnosis of PBC. To the best of our knowledge, biopsy-proven PBC has been reported only in one patient with PMR/GCA.…”

Section: Discussionmentioning

confidence: 99%

“…Less frequent is a cytolytic pattern with elevation of alanine (ALT) and aspartate (AST) transaminases without raised AP and gamma-glutamyltranspeptidase (gGT) [16]. Some investigators hypothesized a possible immunological pathogenesis and, more specifically, reported an association with primary biliary cholangitis (PBC) [17], an autoimmune liver disease characterized by the damage of intrahepatic bile ducts. More than 95% of patients with PBC are positive for antimitochondrial antibodies (AMA).…”

Section: Introductionmentioning

confidence: 99%

Antimitochondrial Antibodies and Primary Biliary Cholangitis in Patients with Polymyalgia Rheumatica/Giant Cell Arteritis

Manzo

Maślińska

Castagna³

et al. 2021

Medicina

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Background and Objectives: Laboratory liver abnormalities can be observed in patients affected with polymyalgia rheumatica (PMR) and/or giant cell arteritis (GCA), especially with a cholestatic pattern. The first objective of our review article is to discuss the potential link between antimitochondrial antibodies (AMA) and/or primary biliary cholangitis (PBC) and PMR/GCA, according to the evidences of literature. The second objective is to discuss the association of PMR/GCA with the other rheumatic diseases having PBC as a common manifestation. Materials and Methods: A literature search was performed on PubMed and Medline (OVID interface) using these terms: polymyalgia rheumatica, giant cell arteritis, antimitochondrial antibodies, primary biliary cholangitis, primary Sjogren’s syndrome, systemic sclerosis, and systemic lupus erythematosus. The search was restricted to all studies and case reports published in any language. Reviews, conference abstracts, comments, and non-original articles were excluded; however, each review’s reference list was scanned for additional publications meeting this study’s aim. When papers reported data partially presented in previous articles, we referred to the most recent published data. Results and Conclusions: Our literature search highlighted that cases reporting an association between AMA, PBC and PMR/GCA were very uncommon; AMA antigenic specificity had never been detected and biopsy-proven PBC was reported only in one patient with PMR/GCA. Finally, the association of PMR/GCA with autoimmune rheumatic diseases in which PBC is relatively common was anecdotal.

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Therapeutic quandary

Willson

1981

Digest Dis Sci

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Polymyalgia rheumatica and primary biliary cirrhosis.

Abstract: No significant abnormality could be seen in an electroencephalograph about two weeks after the event, but a right carotid angiograph showed narrowing of a distal branch of the middle cerebral artery in the region of the trifurcation.

Cited by 17 publications

References 3 publications

Hepatic Granuloma in Polymyalgia Rheumatica

Hepatic Granuloma in Polymyalgia Rheumatica

Antimitochondrial Antibodies and Primary Biliary Cholangitis in Patients with Polymyalgia Rheumatica/Giant Cell Arteritis

Therapeutic quandary

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