Polymorphous Low-Grade Adenocarcinoma of the Nasopharynx Case Report and Review of the Literature

Lengyel, E; Somogyi, A.; Gödény, Mária; Szerdahelyi, Andrea; Németh, György

doi:10.1007/pl00002304

Cited by 25 publications

(16 citation statements)

References 15 publications

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“…It has an almost exclusive propensity to arise from minor salivary glands intraorally, primarily in the palate. PLGA arising from the nasopharynx is extremely rare, and to our knowledge only two cases have been published so far in the literature 3 4. We hereby report an additional case of PLGA in the nasopharynx, emphasising the histological features and the ultrastructural findings.…”

mentioning

confidence: 75%

“…3 4 Clinically, the three patients presented with a variety of complaints including ringing and fullness of the ear, hearing loss, bloody saliva, headache, nasal obstruction and epistaxis. Two of them treated with transpalatal tumour resection without adjuvant chemotherapy or radiotherapy showed no evidence of local recurrence after 22 and 24 months’ follow-up.…”

Section: Discussionmentioning

confidence: 99%

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Polymorphous low-grade adenocarcinoma of the nasopharynx: a case report and brief review

Cc²,

Chien³

et al. 2008

J Clin Pathol

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mentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Polymorphous low-grade adenocarcinoma of the nasopharynx: a case report and brief review

Cc²,

Chien³

et al. 2008

J Clin Pathol

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“…The age of incidence is usually in the sixth to seventh decade of life but rare occurrences in adolescents have been reported [5][6][7]. There is predilection for females in the ratio of 2-4.6:1 [8].…”

Section: Literature Reviewmentioning

confidence: 95%

Polymorphous Low Grade Adenocarcinoma: Literature Review and Report of Lower Lip Lesion with Suspected Lung Metastasis

Olusanya

Akadiri

Akinmoladun

et al. 2011

J. Maxillofac. Oral Surg.

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Polymorphous low grade adenocarcinoma (PLGA) is an uncommon tumour that affects minor salivary glands mainly. It was known to be clinically benign and histologically polymorphic; sometimes misdiagnosed as pleomorphic adenomas, monomorphic adenomas, malignant pleomorphic adenomas, adenoid cystic carcinomas and adenocarcinoma not otherwise specified. More information about PLGA is cumulating in the current literature with new evidences suggesting that the tumour may not be as indolent as it was previously thought. A thorough understanding of the clinical and histological behaviour of the lesion has serious implications in management. Here, a case of lower lip lesion with suspected lung metastasis is reported to exemplify how the clinical behaviour of the lesion may affect management.

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“…The benefits of adjunctive chemotherapy or radiation have not been reported [6]. However, in case of unclear marginal, perineural, or perivascular spread, radiotherapy is recommended [15]. James T. Castle reported an average of 7.2 years for recurrence [8].…”

Section: Discussionmentioning

confidence: 99%

Polymorphous Low-Grade Adenocarcinoma: A Rare Cause of Long-term Epistaxis

Tc¹

2016

Arch Otolaryngol Rhinold

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Polymorphous low-grade adenocarcinoma (PLGA) of the paranasal sinus is an extremely rare disease. PLGA is a minor salivary gland neoplasm that occurs mostly in the junction of the soft and hard palate, followed by the buccal mucosa and upper lip. Only a few cases have been reported in the sinonasal area. PLGA generally follows a benign clinical course with frequent perineural invasion but low metastatic potential.We report on a patient with PLGA in the ethmoid sinus, which presented as a nasal polyp with epistaxis for more than 2 years. The patient received surgical excision with adjuvant radiotherapy and chemotherapy because of perineural and lymphavascular invasion. One year after treatment, the patient was free of disease. PLGA of the paranasal sinus is an extremely rare disease. Epistaxis as the initial presentation is also uncommon. Local recurrences and distant metastasis are rare if complete excision is performed. Long-term follow-up is required.

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Polymorphous Low-Grade Adenocarcinoma of the Nasopharynx Case Report and Review of the Literature

Cited by 25 publications

References 15 publications

Polymorphous low-grade adenocarcinoma of the nasopharynx: a case report and brief review

Polymorphous low-grade adenocarcinoma of the nasopharynx: a case report and brief review

Polymorphous Low Grade Adenocarcinoma: Literature Review and Report of Lower Lip Lesion with Suspected Lung Metastasis

Polymorphous Low-Grade Adenocarcinoma: A Rare Cause of Long-term Epistaxis

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