Polymorphous light eruption

Epstein, John H.

doi:10.1111/j.1600-0781.1997.tb00121.x

Cited by 18 publications

(12 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because of the clear delay between sunlight exposure and the onset of skin lesions, PLE is often suggested to be a delayed-type (type IV) of hypersensitivity (DTH) reaction. The histological appearance of dense superficial and perivascular dermal lymphocytic infiltrates in skin of PLE patients further supports this (Norris et al, 1992;Verheyen et al, 1995;Epstein, 1997).UV radiation, in particular the UVB range (280-315 nm), suppresses the skin immune response (Duthie et al, 1999). In PLE patients, however, UV exposure seems to result in an activation of the skin immune response.…”

mentioning

confidence: 59%

Decreased Neutrophil Skin Infiltration After UVB Exposure in Patients with Polymorphous Light Eruption

Schornagel

Sigurdsson

Nijhuis

et al. 2004

Journal of Investigative Dermatology

View full text Add to dashboard Cite

UV radiation, in particular UVB, suppresses the skin immune response. In patients with polymorphous light eruption (PLE) the skin immune response seems activated after UV exposure. Typical PLE skin lesions can occur as early as several hours after UV exposure. In healthy volunteers, neutrophils infiltrate the skin shortly after UV exposure. The kinetics and mechanisms of neutrophil infiltration in the skin of PLE patients after UVB exposure was studied. Skin biopsies at 0, 3, 6, and 18 h were taken from five PLE patients and six healthy controls after irradiation with three minimal erythema dose UVB. Furthermore, neutrophils were isolated from blood of five PLE patients and six healthy controls to test their chemotactic activity. Immunohistochemical analysis showed a significant decreased neutrophil infiltration in PLE skin after UVB irradiation compared with healthy controls (p<0.05). In both healthy controls and PLE patients, after UVB irradiation, ICAM-1 and E-selectin expression on endothelial cells increased at 6 h after irradiation. Blood neutrophil chemotactic response towards IL-8 and C5a, as well as the expression of cell surface markers involved in adhesion and chemotaxis, was not different between PLE patients and healthy controls. In conclusion, PLE is marked by a decreased skin infiltration of neutrophils after UVB irradiation, possibly leading to a diminished neutrophil-induced suppression.

show abstract

mentioning

confidence: 59%

Decreased Neutrophil Skin Infiltration After UVB Exposure in Patients with Polymorphous Light Eruption

Schornagel

Sigurdsson

Nijhuis

et al. 2004

Journal of Investigative Dermatology

View full text Add to dashboard Cite

show abstract

“…PLE is a common chronic idiopathic photodermatosis. Its clinical presentation and history are typical, and it can be easily differentiated from photoprovoked dermatosis and photoallergic disorders [1, 2, 3, 4, 5]. In our series of patients and in other studies, the papular and papular-vesicular presentation covers approximately 80% of all patients.…”

Section: Discussionmentioning

confidence: 82%

“…The UV action spectrum is controversially discussed. Some authors reported that UVA is the wavelength that induces the specific skin lesions in most patients [5, 8, 9]. Other authors also found a significant number of positive tests for the UVB spectrum [2, 10, 11, 12].…”

Section: Introductionmentioning

confidence: 93%

“…In Europe, there is a strong female predominance, with female:male ratio ranging as high as 9:1 probably because there is a greater willingness in female patients to be seen by a doctor [3, 5]. An increasing incidence was reported for South America [6].…”

Section: Introductionmentioning

confidence: 99%

“…An increasing incidence was reported for South America [6]. The clinical variants of PLE are papular, plaques, papulovesicular, erythema multiforme-like and hemorrhagic type [2, 3, 5]. …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical and Therapeutic Aspects of Polymorphous Light Eruption

et al. 2003

View full text Add to dashboard Cite

Background: Polymorphous light eruption (PLE) is an idiopathic eruption induced by ultraviolet (UV) radiation (UVR). Objective: Evaluation of the clinical aspects, diagnostic criteria of PLE in a major Swiss referral center. Methods: 25 patients with PLE were tested with a standardized protocol for the assessment of photodermatoses. Results: 25 patients (22 women vs. 3 men) were identified. Papular and papular-vesicular eruptions were the most common clinical presentations. 6 of 25 patients had a reduced minimal erythema dose (MED) für UVA and 8 of 25 patients had a reduced MED for UVB. Photoprovocation was positive in 11 of 20 patients for UVA and 7 of 20 patients for UVB. Photohardening with narrow-band UVB was successful in 8 of 10 patients. Combined UVA/UVB therapy had a satisfactory effect in 10 of 15 patients. Narrow-band UVB therapy was still successful after ineffective UVA/UVB therapy. Conclusion: The MED was of no value for the diagnosis of PLE. The typical lesions were reproduced by UVA and UVB photoprovocation. We recommend photohardening with narrow-band UVB (311 nm).

show abstract