Polymorphous adenocarcinoma transforming to Adenoid cystic carcinoma - A case report

Anjali, AK; Tamgadge, Sandhya; Pereira, Treville; Vidhale, Rutuja Gajanan; Sudhamani, S

doi:10.1016/j.adoms.2021.100079

Cited by 2 publications

(3 citation statements)

References 4 publications

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“…This feature rightly correlates and PACs can be seen as blue or basaloid tumours as described by Sheetala et al [ 7 , 8 ]. Some reports also document PAC converting to AdCC [ 14 ], which invites a judicious use of IHC for confirmation of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…According to Kikuchi et al and Simpson et al, numerous other IHC markers can have overlapping expressions; like S-100, CK, vimentin, cyclin D1, p53, p63, oestrogen receptor, androgen receptor, and SOX-10 in cases of PAC, AdCC, and a few other salivary gland tumours [ 2 , 11 ]. Recently use of p40 and CD 117 has been mentioned to get clarity in differentiating between PAC and AdCC [ 14 ]. Many instances might call for multiple markers to be used for confirmation in IHC [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

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Polymorphous Adenocarcinoma: High-Grade Transformation With Immunohistochemical Workup

Muniswammappa¹,

Bavle²,

Makarla³

et al. 2022

Cureus

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Intraoral tumours associated with mucosa are commonly oral squamous cell carcinomas followed by minor salivary gland carcinomas, the commonest being mucoepidermoid carcinoma, adenoid cystic carcinoma, and polymorphous adenocarcinoma (PAC). PAC is the second most common malignant tumour that is found in the minor salivary glands of the oral cavity and rarely exhibits high-grade transformation (HGT). We report a case of a 50-year-old woman with a tumour on her buccal mucosa for six months. Histopathologically, the tumour showed more than 15 histopathological patterns with areas of HGT. The high-grade transformed areas predominantly showed solid patterns, increased mitosis, necrosis, vascular invasion, and perineural invasion. An immunohistochemical (IHC) panel inclusive of p63, SOX-10, S-100, calponin, vimentin, and Ki-67 was done to evaluate the tumour and grade PAC. The Ki-67 index was around 25%-30%, confirming the diagnosis of PAC-HGT. This might be the first case of primary PAC-HGT seen on the buccal mucosa on initial clinical presentation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Polymorphous Adenocarcinoma: High-Grade Transformation With Immunohistochemical Workup

Muniswammappa¹,

Bavle²,

Makarla³

et al. 2022

Cureus

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“…It is more commonly found compared to ACC, surpassed only by pleomorphic adenoma and MEC, according to Darling et al [ 7 ]. Anjali et al [ 8 ] have identified a second variant, polymorphous adenocarcinoma (PAC), characterized by cytologic uniformity and architectural diversity.…”

Section: Introductionmentioning

confidence: 99%

Genetic Rearrangements in Different Salivary Gland Tumors: A Systematic Review

Albalawi

2024

Cureus

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Salivary gland tumors (SGT) encompass a wide range of neoplasms, each with its own unique histological type and clinical presentation. This review hones in on prevalent subtypes of SGTs, including adenoid cystic carcinoma (ACC), salivary duct carcinoma (SDC), and polymorphous adenocarcinoma (PAC). The articles, identified through specific keywords, were meticulously screened in databases like PubMed, Scopus, Google Scholar, and Web of Science from 2018 to 2023. Eight articles delved into genetic modifications among the selected SGT types. A fusion protein known as MYB-NF1B is typically associated with ACC, promoting cell proliferation while inhibiting apoptosis. The presence of MYB modifications in ACCs is a beacon of hope, as it is linked to a more favorable prognosis. In contrast, SDCs often exhibit HER2 expression. The invasive nature of SGTs contributes to their resistance to treatment. In the case of PAC, the role of PRKD1 is particularly noteworthy. PRKD1, integrated with other genes from the PRKD1/2/3 cluster, helps to differentiate PAC from other diseases. Furthermore, the genetic profiles of KTN1-PRKD1) and PPP2R2A:PRKD1 are distinct. The significant genetic variability among SGTs necessitates meticulous examination. This field is in a constant state of evolution, with new discoveries reshaping our understanding. Genetics is a key player in deciphering SGTs and tailoring treatments. This complex neoplasm demands ongoing research to uncover all genetic influences, thereby enhancing diagnostic methodologies, therapeutic strategies, and patient outcomes.

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Polymorphous adenocarcinoma transforming to Adenoid cystic carcinoma - A case report

Cited by 2 publications

References 4 publications

Polymorphous Adenocarcinoma: High-Grade Transformation With Immunohistochemical Workup

Polymorphous Adenocarcinoma: High-Grade Transformation With Immunohistochemical Workup

Genetic Rearrangements in Different Salivary Gland Tumors: A Systematic Review

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