Polymorphonuclear Leukocytes (PMN)—Origins, Functions and Roles in the Rheumatic Diseases

Howe, Graydon; Fordham, J N

doi:10.1007/978-94-011-6624-9_7

Cited by 4 publications

(1 citation statement)

References 114 publications

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“…Evaluation of PMN cell functions has pro ven relevant to the understanding of the physiopathology in non-organ-specific autoimmune diseases [19]. Many studies on the functional state of PMN cells have been car-ricd out with rheumatoid arthritis patients and a multiple defect has been described [19][20][21], As for SLE patients, a consensus concerning the functional state of PMN cells has not yet been reached. Since PMN cells expressing FcyR are thought to be functionally more efficient, it is reasonable to assume that the interpretation of impaired functioning of PMN cells needs to take into account cellfree FcyRIII.…”

Section: Discussionmentioning

confidence: 99%

Cell-Free Fc-Gamma Receptor III in Sera from Patients with Systemic Lupus Erythematosus: Correlation with Clinical and Biological Features

Hutin¹,

Lamour²,

Pennec³

et al. 1994

Int Arch Allergy Immunol

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Fifty patients (41 females and 9 males, ranging in age from 12 to 79 years) with systemic lupus erythematosus (SLE) and 20 normal controls were evaluated for the presence of plasma cell-free Fcγ receptor III (FcγRIII) using an ELISA based upon a sandwich of two monoclonal antibodies. The standard curve was obtained with serial dilutions of recombinant FcγRIII. In the patients, the cell-free FcγRIII levels ranged from to 1.76 μg/ml, while it did not exceed 0.21 μg/ml in the controls. Assuming that the cutoff is 0.25 μg/ml, 11 SLE patients and no controls had elevated cell-free FcγRIII levels in the serum. Among the SLE patients, the level of cell-free FcγRIII was significantly lower (p = 0.05) in 4 patients with sicca syndrome than in the remaining 46. Furthermore, cell-free FcγRIII levels appeared to be lower in 11 patients with renal involvement than in those without. For the biological parameters, we observed that the 27 patients who presented lymphopenia also had a lower level of cell-free FcγRIII when compared to the 23 patients without lymphopenia (0.09 ± 0.19 versus 0.35 ± 0.52 μg/ml; p = 0.05). Circulating cell-free FcγRIII may originate from shedding by presumably activated polymorphonuclear cells.

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Section: Discussionmentioning

confidence: 99%

Cell-Free Fc-Gamma Receptor III in Sera from Patients with Systemic Lupus Erythematosus: Correlation with Clinical and Biological Features

Hutin¹,

Lamour²,

Pennec³

et al. 1994

Int Arch Allergy Immunol

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Neutrophil Polymorphonuclear Cell Function in Rheumatoid Arthritis

Youinou¹,

Lamour²,

Dumay³

et al. 1992

Rheumatoid Arthritis

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Effect of feverfew on phagocytosis and killing ofCandida guilliermondii by neutrophils

et al. 1988

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The in vitro effect of the herbal remedy feverfew on neutrophil function was examined. It was shown that addition of feverfew extract inhibited phagocytosis of Candida guilliermondii and its overall killing. However, intracellular killing was not affected, suggesting that the apparent defect in total killing merely reflected the failure of uptake. The implications for the in vivo effects of feverfew are discussed.

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Polymorphonuclear Leukocytes (PMN)—Origins, Functions and Roles in the Rheumatic Diseases

Cited by 4 publications

References 114 publications

Cell-Free Fc-Gamma Receptor III in Sera from Patients with Systemic Lupus Erythematosus: Correlation with Clinical and Biological Features

Cell-Free Fc-Gamma Receptor III in Sera from Patients with Systemic Lupus Erythematosus: Correlation with Clinical and Biological Features

Neutrophil Polymorphonuclear Cell Function in Rheumatoid Arthritis

Effect of feverfew on phagocytosis and killing ofCandida guilliermondii by neutrophils

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