Polymorphonuclear leucocyte priming in long intermittent nocturnal haemodialysis patients--is melatonin a player?

Geron, Ronit; Shurtz-Swirski, Revital; Sela, Shifra; Gurevitch, Yevgeny; Tanasijtchouk, Tatiana; Orr, Zila Shenn; Школьник, Г. С.; Tanhilevski, Olga; Kristal, Batya

doi:10.1093/ndt/gfl359

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…This property can be of interesting value in this patient group as oxidative stress is often seen in CKD patients. A primed state of polymorphonuclear cells, responsible for oxidative stress in haemodialysis patients, was associated with lower nocturnal plasma melatonin levels [24]. In addition, melatonin has also been associated with the immune response, impairing the mounting of an inflammatory response, while melatonin produced at the site of the injury by immunocompetent cells exerts antiinflammatory effects [25].…”

Section: Melatoninmentioning

confidence: 99%

Impairment of endogenous melatonin rhythm is related to the degree of chronic kidney disease (CREAM study)

Koch¹,

Putten

Someren³

et al. 2009

Nephrology Dialysis Transplantation

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Section: Melatoninmentioning

confidence: 99%

Impairment of endogenous melatonin rhythm is related to the degree of chronic kidney disease (CREAM study)

Koch¹,

Putten

Someren³

et al. 2009

Nephrology Dialysis Transplantation

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“…The melatonin rhythm was more likely to be diminished in hemodialysis patients than in patients with chronic renal insufficiency who were not, concluding that hemodialysis affects the rhythm [ 23 ]. Diminished melatonin levels are associated with more pronounced sleep disturbances in hemodialysis patients [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Melatonin receptor 1A gene polymorphism rs13140012 and serum melatonin in atherosclerotic versus non-atherosclerotic Egyptian ESRD patients: pilot study

Aghoury

Tayae

Kholy

et al. 2020

Heliyon

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Aim To study the relationship between melatonin levels and Melatonin membrane receptor 1A ( MTNR1A ) SNP (rs13140012) in end-stage renal disease patients (ESRD) in Alexandria, Egypt on maintenance hemodialysis with or without atherosclerosis. Materials and methods 40 end-stage renal disease patients on regular hemodialysis were divided into 2 subgroups, one with (n = 20) and one without atherosclerosis (n = 20) and normal subjects (n = 40). Serum melatonin, carotid intimal medial thickness (CIMT) were measured. Melatonin membrane receptor 1A ( MTNR1A ) SNP (rs13140012) genotyping was done using 5'nuclease Allelic discrimination. Results Serum melatonin was significantly lower in ESRD patients [1.6 to 11.30 (pg/mL) with a median of 2.5] than the control group [20.50 to 56.40 (pg/mL) with a median of 35.20]. Serum melatonin was significantly lower in atherosclerotic patients subgroup [1.6–2.50 (pg/mL) with a median value of 2.30] than non-atherosclerotic patients subgroup [2.0–11.30 (pg/mL) with a median of 4.9]. No significant association was found between serum melatonin and ( MTNR1A ) SNP (rs13140012) (p = 0.633). Conclusion These results lead us to suggest that melatonin production is impaired in ESRD patients (included in this pilot study), and this impairment is more evident in atherosclerotic ESRD patients.

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“…Human leucocyte reactive oxygen species show circadian variations and they might possibly influence the occurrence of cardiovascular incidents (Larsen and Lyberg 2006). The finding of lower superoxide release from granulocytes at higher melatonin levels opens up new research opportunities for melatonin therapy (Geron et al 2006). Some patients with low melatonin activity may benefit from both improvement in their sleep quality and a reduction of granulocyte mediated oxidative stress after melatonin administration.…”

Section: Haemato-immune Oscillationsmentioning

confidence: 99%

Advances in chronohaematology

Berger¹

2008

JAB

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The circadian rhythms of the haemato-immune system seem to be synchronized by two clocks: the hypothalamic endogenous, and the exogenous which is based on environmental stimuli. The suprachiasmatic nucleus is not only a circadian clock, it also synchronizes peripheral oscillators and integrates light information through the retino-hypothalamic tract. The role of the "peripheral" clock genes in mature leucocytes still remains an unanswered question as well as the role of clock proteins in "non-clock" physiology. The circadian rhythms may be a basis for circannual variations, although the molecular bases of such rhythms remain a mystery. There are several hormones which have a significant impact on haematological characteristics; the finding of a lower superoxide release from granulocytes at higher melatonin levels opens up new research opportunities for melatonin therapy. Discrepancies between circadian changes in mRNAs and the appropriate protein participating in haemocoagulation and fibrinolysis may indicate that we do not know their control processes or their genetic background well, although this problem has now opened up a new area for pharmacological research. The endogenous clock facilitates an alternation in the immune system which counters external attacks in daytime and induces repair and development by night.

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Polymorphonuclear leucocyte priming in long intermittent nocturnal haemodialysis patients--is melatonin a player?

Cited by 7 publications

References 15 publications

Impairment of endogenous melatonin rhythm is related to the degree of chronic kidney disease (CREAM study)

Impairment of endogenous melatonin rhythm is related to the degree of chronic kidney disease (CREAM study)

Melatonin receptor 1A gene polymorphism rs13140012 and serum melatonin in atherosclerotic versus non-atherosclerotic Egyptian ESRD patients: pilot study

Advances in chronohaematology

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