Polymorphisms within the prolactin and growth hormone/insulin-like growth factor-1 functional pathways associated with fertility traits in Holstein cows raised in a hot-humid climate

Leyva-Corona, José Clemente; Reyna-Granados, Javier R.; Zamorano‐Algandar, Ricardo; Sánchez-Castro, Miguel A; Thomas, M. G.; Enns, R. M.; Speidel, Scott E; Medrano, Juan F.; Rincón, Gonzalo; Luna‐Nevárez, Pablo

doi:10.1007/s11250-018-1645-0

Cited by 23 publications

(18 citation statements)

References 33 publications

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“…However, understanding which trait is driving the patterns of selection at a locus remains challenging. Especially as many genes and loci can be associated with a variety of potential traits, with the GHR locus, observed to be under selection in this study, linked to a range of fertility 38 , milk 20 and meat 39 production phenotypes in cattle. We show though that the strength of selection at these loci can be strongly correlated to the differences between breeds of certain traits, providing potential clues as to the driving forces behind the selective sweeps.…”

Section: Discussionmentioning

confidence: 81%

Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication

et al. 2020

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More people globally depend on the water buffalo than any other domesticated species, and as the most closely related domesticated species to cattle they can provide important insights into the shared evolutionary basis of domestication. Here, we sequence the genomes of 79 water buffalo across seven breeds and compare patterns of between breed selective sweeps with those seen for 294 cattle genomes representing 13 global breeds. The genomic regions under selection between cattle breeds significantly overlap regions linked to stature in human genetic studies, with a disproportionate number of these loci also shown to be under selection between water buffalo breeds. Investigation of potential functional variants in the water buffalo genome identifies a rare example of convergent domestication down to the same mutation having independently occurred and been selected for across domesticated species. Cross-species comparisons of recent selective sweeps can consequently help identify and refine important loci linked to domestication.

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Section: Discussionmentioning

confidence: 81%

Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication

et al. 2020

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“…Another very significant QTL for milk yield in Holstein was identified on BTA20 at ~38 Mb. The lead SNP of this QTL was located near the PRLR gene which has previously been associated with fertility in Holstein cows (Leyva-Corona et al, 2018 ; Marete et al, 2018b ). The majority of the associated SNP with fertility, a low heritability trait, were 50 k chip variants.…”

Section: Discussionmentioning

confidence: 94%

A Meta-Analysis Including Pre-selected Sequence Variants Associated With Seven Traits in Three French Dairy Cattle Populations

et al. 2018

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A within-breed genome-wide association study (GWAS) is useful when identifying the QTL that segregates in a breed. However, an across-breed meta-analysis can be used to increase the power of identification and precise localization of QTL that segregate in multiple breeds. Precise localization will allow including QTL information from other breeds in genomic prediction due to the persistence of the linkage phase between the causal variant and the marker. This study aimed to identify and confirm QTL detected in within-breed GWAS through a meta-analysis in three French dairy cattle breeds. A set of sequence variants selected based on their functional annotations were imputed into 50 k genotypes for 46,732 Holstein, 20,096 Montbeliarde, and 11,944 Normande cows to identify QTL for milk production, the success rate at insemination of cows (fertility) and stature. We conducted within-breed GWAS followed by across-breed meta-analysis using a weighted Z-scores model on the GWAS summary data (i.e., P-values, effect direction, and sample size). After Bonferroni correction, the GWAS result identified 21,956 significantly associated SNP (PFWER < 0.05), while meta-analysis result identified 9,604 significant SNP (PFWER < 0.05) associated with the phenotypes. The meta-analysis identified 36 QTL for milk yield, 48 QTL for fat yield and percentage, 29 QTL for protein yield and percentage, 13 QTL for fertility, and 16 QTL for stature. Some of these QTL were not significant in the within-breed GWAS. Some previously identified causal variants were confirmed, e.g., BTA14:1802265 (fat percentage, P = 1.5 × 10−760; protein percentage, P = 7.61 × 10−348) both mapping the DGAT1-K232A mutation and BTA14:25006125 (P = 8.58 × 10−140) mapping PLAG1 gene was confirmed for stature in Montbeliarde. New QTL lead SNP shared between breeds included the intronic variant rs109205829 (NFIB gene), and the intergenic variant rs41592357 (1.38 Mb upstream of the CNTN6 gene and 0.65 Mb downstream of the CNTN4 gene). Rs110425867 (ZFAT gene) was the top variant associated with fertility, and new QTL lead SNP included rs109483390 (0.1 Mb upstream of the TNFAIP3 gene and 0.07 Mb downstream of PERP gene), and rs42412333 (0.45 Mb downstream of the RPL10L gene). An across-breed meta-analysis had greater power to detect QTL as opposed to a within breed GWAS. The QTL detected here can be incorporated in routine genomic predictions.

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“…Therefore, these hormones may be used to enhance the milk production. HS suppresses the production of GH and PRL and caused the alteration of energy metabolism [32]. Higher plasma concentrations of GH and PRL in NCG-treated cows than those in the control may explain the enhanced energy metabolism for milk synthesis and improved the productive performance of dairy cows under HS.…”

Section: Discussionmentioning

confidence: 96%

Effects of dietary N-carbamylglutamate supplementation on milk production performance, nutrient digestibility and blood metabolomics of lactating Holstein cows under heat stress

Ren

et al. 2021

Animal Feed Science and Technology

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Background: Heat stress (HS) becomes a serious threat to dairy cow industry in certain circumstances, Ncarbamylglutamate (NCG) is a novel feed additive that may be used to alleviate HS. However, the effects and mechanisms of NCG on dairy cows under HS are still unknown. A total of 48 Holstein dairy cows with similar days in milk (154.37±13.56 d), parity (1-3), and body condition score (BCS) were randomly divided into 4 groups of 12 animals each. Under HS, the cows were fed a TMR diet supplemented with 0 (control), 15, 20, 25 g of NCG/d per cow for 60 days. Milk production performance was recorded and serum parameters were examined. Meanwhile, metabolomics study of plasma based on liquid chromatography-mass spectrometry (LC-MS) was also applied to investigate metabolites and pathways in response to NCG supplementation.Results: Milk yield (MY) was increased but milk urine nitrogen (MUN) was reduced by the NCG treatment.Addition of 15 g of NCG/d increased the milk protein percentage (MPP) compared with the control. No effect of NCG was observed on dry matter intake (DMI), lactose percentage (LP), milk fat percentage (MFP) and somatic cell count (SCC). Serum glucose (GLU) levels in cows fed with 15, 20, 25 g of NCG/d were increased by 14.35%, 19.34% and 18.63% in comparison with the control. Meanwhile, the concentrations of blood urea nitrogen (BUN) and blood ammonia (BA) were decreased with the addition of NCG. Results for antioxidant capacity and immune function showed bene cial effects of NCG, such as the increases in total antioxidant capacity (T-AOC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), IgG, IgM and IgA. Clear separations of plasma metabolic pro les between control and NCG groups were observed in the score plots. Sixteen different metabolites involved in metabolisms of amino acids, ketone bodies, butanoate and energy, as well as gut microbiome-derived metabolism were regulated by NCG supplementation.Conclusions: This study found that NCG treatment improved antioxidant capacity, immune function, production performance, and metabolic pro le of dairy cows under HS and provided new evidence for the better utilization of NCG.

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Polymorphisms within the prolactin and growth hormone/insulin-like growth factor-1 functional pathways associated with fertility traits in Holstein cows raised in a hot-humid climate

Cited by 23 publications

References 33 publications

Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication

Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication

A Meta-Analysis Including Pre-selected Sequence Variants Associated With Seven Traits in Three French Dairy Cattle Populations

Effects of dietary N-carbamylglutamate supplementation on milk production performance, nutrient digestibility and blood metabolomics of lactating Holstein cows under heat stress

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