Polymorphisms of tumor necrosis factor-α promoter region for susceptibility to HLA-B27-positive ankylosing spondylitis in Korean population

Chung, Won-Tae; Choe, Jung‐Yoon; Jang, Woncheol; Park, Su Min; Ahn, Young Chang; Yoon, Il Kyu; Kim, Tae‐Hwan; Nam, Youn-Hyoung; Park, Sunghoon; Lee, Sung-Won; Kim, Seong-Kyu

doi:10.1007/s00296-010-1434-1

Cited by 24 publications

(19 citation statements)

References 26 publications

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“…Of the 253 publications retrieved initially, 10 studies, which involved 987 ankylosing spondylitis patients and 1041 controls (Cai et al 2009; Chatzikyriakidou et al 2009; Chen et al 2004; Chung et al 2011; Ji et al 2013; Li et al 2007; Lin 2007a, b; Mei et al 2009; Tong et al 2012; Yang et al 2007), were ultimately identified. Figure 1 shows the flowchart of the study selection process.…”

Section: Resultsmentioning

confidence: 99%

“…In the present meta-analysis, we included 10 studies (Cai et al 2009; Chatzikyriakidou et al 2009; Chen et al 2004; Chung et al 2011; Ji et al 2013; Li et al 2007; Lin 2007a, b; Mei et al 2009; Tong et al 2012; Yang et al 2007) that addressed the association between TNF-α −857 C/T polymorphism and risk of developing ankylosing spondylitis. The results of this meta-analysis indicated that T allele carriers presented a 1.76-fold higher risk of developing ankylosing spondylitis than C allele carriers, CT genotype carriers presented a 2.30-fold higher risk than CC genotype and TT + CT genotype carriers presented a 2.26-fold higher risk than CC genotype.…”

Section: Discussionmentioning

confidence: 99%

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Genetic association between TNF-α −857 C/T polymorphism and ankylosing spondylitis susceptibility: evidence from a meta-analysis

Tang

Bian

et al. 2016

SpringerPlus

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Certain studies have suggested that the tumor necrosis factor-α (TNF-α) −857 C/T polymorphism is associated with risk of ankylosing spondylitis. However, the conclusions remain controversial. Therefore, we performed a meta-analysis to provide a more precise conclusion. Such databases as PubMed, Embase, CBM, CNKI, and Wanfang Data were searched to identify relevant studies up to August 26, 2015. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the association between TNF-α −857 C/T polymorphism and ankylosing spondylitis susceptibility. A total of 10 studies were included in the meta-analysis. Overall, an elevated risk between TNF-α −857 C/T polymorphism and ankylosing spondylitis was observed in three genetic model (T vs. C: OR 1.86, 95% CI 1.19–2.92; CT vs. CC: OR 2.51, 95% CI 1.49–4.23; TT + CT vs. CC: OR 2.46, 95% CI 1.40–4.30), except in homozygote model (TT vs. CC: OR 2.41, 95% CI 0.96–6.06) and recessive model (TT vs. CT + CC: OR 1.54, 95% CI 0.71–3.35). Sensitivity analysis showed the overall results were robust. Subgroup analyses according to Hardy–Weinberg equilibrium and ethnicity showed that the increased risk of ankylosing spondylitis were predominant in Asian population. This meta-analysis indicated that TNF-α −857 C/T polymorphism might increase the susceptibility of ankylosing spondylitis, especially in Asians. Further studies were needed to verify the conclusion.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Genetic association between TNF-α −857 C/T polymorphism and ankylosing spondylitis susceptibility: evidence from a meta-analysis

Tang

Bian

et al. 2016

SpringerPlus

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“…Studies on the relation between TNF-α SNPs and AS have shown controversial results. For example, TNF-α polymorphisms had no independent effect on AS susceptibility (Chung et al 2011; Li et al 2010) but their modulating effect on TNF-α expression were well relevant to the phenotypic diversity in AS (Lee and Song 2009; Poddubnyy et al 2011). In contrast, Vargas-Alarcón et al (2006) and Shiau et al (2007) showed an association of −308G/A polymorphism with susceptibility to AS.…”

Section: Association Between Tnf-α Genetic Polymorphisms and Autoimmumentioning

confidence: 99%

“…In contrast, Vargas-Alarcón et al (2006) and Shiau et al (2007) showed an association of −308G/A polymorphism with susceptibility to AS. Moreover, the A allele was thought to have a protective role against AS (Chung et al 2011; Nossent et al 2014), and was associated with a lower risk of developing AS, and with the age at disease onset, disease severity and response to anti-TNF treatment (Manolova et al 2014). …”

Section: Association Between Tnf-α Genetic Polymorphisms and Autoimmumentioning

confidence: 99%

TNF-α gene polymorphisms and expression

2016

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Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine with an important role in the pathogenesis of several diseases. Its encoding gene is located in the short arm of chromosome 6 in the major histocompatibility complex class III region. Most of the TNF-α gene polymorphisms are located in its promoter region and they are thought to affect the susceptibility and/or severity of different human diseases. This review summarizes the data related to the association between TNF-α gene and its receptor polymorphisms, and the development of autoimmune diseases. Among these polymorphisms the −308G/A TNF-α promotor polymorphism has been associated several times with the the development of autoimmune diseases, however some discrepant results have been recorded. The other TNF-α gene polymorphisms had little or no association with autoimmune diseases. Current results about the molecules controlling TNF-α expression are also presented. The discrepancy between different records could be related partly to either the differences in the ethnic origin or number of the studied individuals, or the abundance and activation of other molecules that interact with the TNF-α promotor region or other elements.

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“…TNFRII is specifically involved in the stimulation of T and B lymphocytes (Vandenabeele et al, 1995), and the exon 6 variation located at nt587 is a T to G SNP that results in the substitution of methionine by arginine at codon 196. Polymorphisms of the TNF-α gene have been intensively studied (Li et al, 2010;Chung et al, 2011), among which, the TNFRII nt587 polymorphism has been frequently reported in chronic autoimmune disease such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and alcoholic liver disease. Komata et al (1999) demonstrated an association between SLE and the G allele of TNFRII nt587 in a Japanese population.…”

Section: Tnfrαnt587mentioning

confidence: 99%

Tumor necrosis factor receptor-II nt587 polymorphism in Chinese Han patients with ankylosing spondylitis

Li¹,

Wang²,

Ma³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. We aimed to explore the association between the onset of ankylosing spondylitis (AS) and nt587 polymorphisms of the tumor necrosis factor receptor II (TNFRII) gene in the Han population of Hunan Province, China. Correlation analysis was performed in a case-control study involving 100 AS cases and 100 healthy controls. The nt587 single nucleotide polymorphism of the TNFRII gene was examined by polymerase chain reaction-restriction fragment length polymorphism. The relationship between AS and the frequencies of genotypes and alleles in TNFRII nt587 were analyzed using the SPSS software. There were 43 cases with the TNFRII nt587 T/T genotype, 32 cases with the TNFRII nt587 T/G genotype, and 25 cases with the TNFRII nt587 G/G genotype. In the 100 healthy controls, 56 subjects had the TNFRII nt587 5191 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (3): 5190-5198 (2014) Relationship between TNFRII polymorphisms and AS T/T genotype, 34 had the TNFRII nt587 T/G genotype, and 10 had the TNFRII nt587 G/G genotype. The G allele frequency of the AS group was significantly higher (χ 2 = 8.734, P = 0.003) than that in the control group (41.0 vs 27.0%). The odds ratio (OR) in AS cases with the TNFRII nt587 G/G genotype was 3.256, which was obviously higher than in those with T/G (OR = 1.226) and T/T (OR = 1.0) genotype. The polymorphism at position nt587 of the TNFRII gene was found to be associated with AS, and the TNFRII nt587 G allele may play an important role in AS susceptibility. The TNFRII nt587 G/G genotype may increase the risk of developing AS in the Hunan population.

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Polymorphisms of tumor necrosis factor-α promoter region for susceptibility to HLA-B27-positive ankylosing spondylitis in Korean population

Cited by 24 publications

References 26 publications

Genetic association between TNF-α −857 C/T polymorphism and ankylosing spondylitis susceptibility: evidence from a meta-analysis

Genetic association between TNF-α −857 C/T polymorphism and ankylosing spondylitis susceptibility: evidence from a meta-analysis

TNF-α gene polymorphisms and expression

Tumor necrosis factor receptor-II nt587 polymorphism in Chinese Han patients with ankylosing spondylitis

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