Polymorphisms of TLR4 but not CD14 are associated with a decreased risk of aggressive periodontitis

James, Jacqueline; Poulton, Kay; Haworth, Simone; Payne, Debbie; McKay, Ian J.; Clarke, Fiona M.; Hughes, Francis J.; Linden, Gerard J.

doi:10.1111/j.1600-051x.2006.01030.x

Cited by 54 publications

(61 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Significantly higher prevalence of this allele was shown in chronic periodontitis (p = 0.0495) and the absence of significant results for people with a general diagnosis of periodontitis (p = 0.156) and for the AgP group (p = 0.755) was reported. Only two homozygous subjects were found, one in the CP [22] and one in the control group [21].…”

Section: Studies Included In the Meta-analysismentioning

confidence: 95%

“…The rest of the publications included 2 polymorphisms. In 8 articles [18, 21, 23, 25-27, 30, 31] study groups consisted of subjects with chronic periodontitis, in 2 [24,29] aggressive periodontitis and in 5 [19,20,22,28,32] The frequency of Asp299Gly polymorphism was 12.83% among subjects with periodontitis (13.76% in CP and 10.57% in AgP) and 12.14% in the control group. The frequency of Asp299Gly allele in periodontitis was 6.44% (6.93% in CP and 5.28% in AgP) and 5.47% in the control group.…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

“…Almost all subjects were heterozygotes for Asp299Gly. Only James et al [22] identified one homozygous individual in CP and three studies described such patients in the control groups [21,24,31].…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

See 2 more Smart Citations

Polymorphisms of Toll-Like Receptor 4 as a Risk Factor for Periodontitis: Meta-Analysis

2015

View full text Add to dashboard Cite

Section: Studies Included In the Meta-analysismentioning

confidence: 95%

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

See 1 more Smart Citation

Polymorphisms of Toll-Like Receptor 4 as a Risk Factor for Periodontitis: Meta-Analysis

2015

View full text Add to dashboard Cite

“…Pro moter polymorphis ms of the CD14 gene, however, did not influence susceptibility to inflammatory periodontitis in the population cohorts studied [29]. Li et al provided evidence stating FokI polymo rphism of vitamin D receptor gene might be associated with generalized aggressive periodontitis in Chinese patients.…”

Section: Aggressive Peri Odontitismentioning

confidence: 90%

Association of Periodontal Diseases with Genetic Polymorphisms

Gandhi¹,

Kothiwale²

2012

IJGE

View full text Add to dashboard Cite

Periodontal diseases are multifactorial in nature. While microbial and other environmental factors are believed to initiate and modulate periodontal disease progression, there now exist strong supporting data that genetic polymorphis ms play a role in the predisposition to and progression of periodontal diseases. Variat ions in any number or combination of genes that control the development of the periodontal tissues or the competency of the cellular and humoral immune systems could affect an individual's risk fo r d isease. A corollary of this realization is that if the genetic basis of periodontal disease susceptibility can be understood, such information may have diagnostic and therapeutic value. This review aims to update the clin ician about various genetic polymorphis ms associated with periodontal diseases to aid in a better approach to the condition in the future.

show abstract

“…The role of each TLR in innate immunity against bacteria and how TLRs active inflammatory cytokines and antimicrobial peptides have been well documented [2,3]. In addition, Asp299Gly and Thr399Ile mis-sense mutations in extracellular domain of TLR4 have been associated with decreased late diabetic complication and aggressive periodontitis [4,5].…”

mentioning

confidence: 99%

Receptors in Oral Epithelial Innate Immunity

Chung¹

2015

J Bioanal Biomed

View full text Add to dashboard Cite

EditorialOpen AccessAs the first line of defense between the outside environment and the host, epithelial tissues utilize an elaborate signaling network in the presence of colonizing bacteria. A number of signal transduction pathways and Pattern Recognition Receptors (PRRs) are involved in the bacterial-host communication and the production of innate immune responses by the host. Oral epithelia, in particular, are constantly exposed to hundreds of different species of bacteria, yet maintain healthy homeostasis. Numerous studies have reported on a complex biological system in the oral epithelia and what roles different epithelial PRRs play on the induction of appropriate innate immune responses.

show abstract

Polymorphisms of TLR4 but not CD14 are associated with a decreased risk of aggressive periodontitis

Abstract: It is concluded that in West European Caucasians, the Asp299Gly TLR4 gene polymorphism is associated with a decreased risk of AgP but not CP. Promoter polymorphisms of the CD14 gene, however, did not influence susceptibility to inflammatory periodontitis in the population cohorts studied.

Cited by 54 publications

References 41 publications

Polymorphisms of Toll-Like Receptor 4 as a Risk Factor for Periodontitis: Meta-Analysis

Polymorphisms of Toll-Like Receptor 4 as a Risk Factor for Periodontitis: Meta-Analysis

Association of Periodontal Diseases with Genetic Polymorphisms

Receptors in Oral Epithelial Innate Immunity

Contact Info

Product

Resources

About