Polymorphisms of the XRCC1, XRCC3, &amp; XPDgenes, and colorectal cancer risk: a case-control study in Taiwan

Yeh, Chih Ching; Sung, Fung Chang; Tang, Reiping; Chang-Chieh, Chung Rong; Hsieh, Ling Ling

doi:10.1186/1471-2407-5-12

Cited by 88 publications

(77 citation statements)

References 42 publications

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“…(95% CI=0.96-5.4). Our findings are in concordance with those reported by Mort et al (2003), Krupa et al (2011) andImporta et al (2008) and contradictory to those reported by many authors (Tranah et al, 2004;Stern et al, 2005;Yeh et al, 2005;Skjelbred et al, 2006) which show negative association. Also, it has been suggested that variant genotypes of XRCC3 have decreased repair capacity and thus individuals with this genotypes do not repair double strand DNA breaks efficiently by HRR and are susceptible to risk of CRC (Krupa et al, 2011).…”

Section: Discussioncontrasting

confidence: 56%

XRCC3 Thr241Met Gene Polymorphism and Risk of Colorectal Cancer in Kashmir: a Case Control Study

Nissar

Sameer²,

Lone³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussioncontrasting

confidence: 56%

XRCC3 Thr241Met Gene Polymorphism and Risk of Colorectal Cancer in Kashmir: a Case Control Study

Nissar

Sameer²,

Lone³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…XRCC3 deficient HCT116 cells have shown increased sensitivity to cisplatin and mitomycin C (42). Although some studies have shown no association between polymorphisms in XRCC3 and colorectal cancer risk (43)(44)(45)(46) other studies have (47,48), and in addition XRCC3 polymorphisms have also been associated with breast and lung cancer susceptibility (41,49).…”

Section: Discussionmentioning

confidence: 99%

Aspirin and alterations in DNA repair proteins in the SW480 colorectal cancer cell line

Nicholl¹

2010

Oncol Rep

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Abstract. Regular aspirin intake is associated with a reduction in the incidence of colorectal cancer. Aspirin has been shown to be cytotoxic to colorectal cancer cells in vitro. The molecular basis for this cytotoxicity is controversial, with a number of competing hypotheses in circulation. One suggestion is that the protective effect is related to the induction of expression of the DNA mismatch repair (MMR) proteins hMLH1, hMSH2, hMSH6 and hPMS2 in DNA MMR proficient cells. We report that treatment of the DNA MMR competent/p53 mutant colorectal cancer cell line SW480 with 1 mM aspirin for 48 h caused changes in mRNA expression of several key genes involved in DNA damage signalling pathways, including a significant down-regulation in transcription of the genes ATR, BRCA1 and MAPK12. Increases in the transcription of XRCC3 and GADD45· genes are also reported. Regulation of these genes could potentially have profound effects on colorectal cancer cells and may play a role in the observed chemoprotective effect of aspirin in vivo. Although a correlation was not seen between transcript and protein levels of ATR, BRCA1 and GADD45·, an increase in XRCC3 encoded protein expression upon aspirin treatment in SW480 cells was observed by immunoblotting, immunofluorescence and immunohistochemical analysis. This is the first report of XRCC3 gene transcription and encoded protein expression being susceptible to exposure to the non-steroidal anti-inflammatory drug, aspirin. Furthermore, this study indicates that alterations in gene transcription seen in microarray studies must be verified at the protein level.

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“…Most studies report a reduced risk of cancer associated with the 194Trp allele (Goode et al, 2002). The 399 polymorphism have been associated with a number of cancers, although results have been inconsistent (Abdel-Rahman et al, 2000;Goode et al, 2002;Mort et al, 2003;Nexo et al, 2003;Vogel et al, 2004;Hong et al, 2005;Yeh et al, 2005). Few studies have investigated the association between the XRCC1 280His allele and risk of cancer.…”

Section: Introductionmentioning

confidence: 99%

Predictive Value of XRCC1 and XRCC3 Gene Polymorphisms for Risk of Ovarian Cancer Death After Chemotherapy

Cheng

Xue²,

Li³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Objective: To investigate any association between XRCC1 and XRCC3 polymorphisms and outcome of platinum-based chemotherapy in ovarian cancer patients. Methods: With a prospective study design was cases were consecutively collected from January 2005 to January 2007. All 310 included patients were followed-up until the end of January 2010. Genotyping of XRCC1 and XRCC3 polymorphisms was conducted by TaqMan Gene Expression assays. Results: A total of 191 patients died during follow-up. Our study showed a lower survival rate in XRCC1 399 Arg/Arg genotype than Gln/ Gln, with a significant increased risk of death (HR=1.69, 95%CI=1.07-2.78). Similarly, those carrying XRCC3 Thr/ Thr genotype had a increased risk as compare to the Met/Met genotype, with a HR (95% CI) of 1.90 (1.12-3.41). There was no significant association between XRCC1 Arg194Trp and XRCC1Arg280His gene polymorphisms and ovarian cancer death. Conclusion: Our study demonstrates that polymorphisms in DNA repair genes have roles in the susceptibility and survival of ovarian cancer patients.

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Polymorphisms of the XRCC1, XRCC3, & XPDgenes, and colorectal cancer risk: a case-control study in Taiwan

Cited by 88 publications

References 42 publications

XRCC3 Thr241Met Gene Polymorphism and Risk of Colorectal Cancer in Kashmir: a Case Control Study

XRCC3 Thr241Met Gene Polymorphism and Risk of Colorectal Cancer in Kashmir: a Case Control Study

Aspirin and alterations in DNA repair proteins in the SW480 colorectal cancer cell line

Predictive Value of XRCC1 and XRCC3 Gene Polymorphisms for Risk of Ovarian Cancer Death After Chemotherapy

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