Polymorphisms of the serotonin transporter gene and post-stroke depression: a meta-analysis

Abstract

The 5-HTTLPR SS genotype may be a risk factor for PSD. The 5-HTTLPR LL genotype showed a significant negative association with PSD. Further research to assess the sensitivity and specificity of predicting the risk of developing PSD by screening for the 5-HTTLPR genotype in stroke patients is required.

Variants of SLC6A4 in depression risk following severe TBI

“…Also, subjects in that study were not stratified by pre-morbid mood disorders; Our study only showed genetic associations with PTD when pre-morbid subjects were excluded or whose effects were adjusted for in multivariate analysis (Table III). Similarly, studies in post-stroke depression suggest S-homozygotes show increased rates of depression, but many of these studies did not exclude or separately analyse subjects with a history of pre-injury depression [34].…”

Relationship between 5-HTTLPR polymorphism and post-stroke depression

“…The short variation (S) allele of the 5-HTTLPR polymorphism led to 14 repeats of base pair sequences. In contrast, a long variation (L) allele led to 16 repeats of base pair sequences (Mak et al, 2013). The LL genotype had a band of 419 bp; the LS genotype had bands of 419 and 376 bp; and the SS genotype had a band of 376 bp.…”

“…PSD leads to a diminished quality of life, delayed recovery of neurological function, increased mortality, and a greater burden on families and society (Hackett et al, 2010). In recent years, much attention has been paid to the serotonin (5-hydroxytryptamine; 5-HT) transporter gene-linked polymorphic region (5-HTTLPR) genotype in PSD patients and the neurotransmitter serotonin hypothesis, but current studies show that the correlation between 5-HTTLPR and PSD is controversial (Fang and Cheng, 2009;Choi-Kwon et al, 2012;Mak et al, 2013). The present study further explores the association between the 5-HTTLPR and PSD from a biological viewpoint in order to provide a theoretical basis for the etiology of PSD.…”

Serotonin transporter gene polymorphisms may be associated with poststroke neurological recovery after escitalopram use

“…Our study showed that SERT polymorphisms are not related to the presence of poststroke depression or responsiveness of SSRIs on depression. Although the 5-HTTLPR s/s genotype has been suggested as a risk factor for poststroke depression,40 heterogeneous study designs preclude a conclusion. Further studies are needed to clarify this issue.…”