Polymorphisms of the interleukin-6 gene are associated with bone mineral density

Murray, R; Grant, S. F. A.; Reld, DM; Ralston, SH

doi:10.1007/bf02499894

Cited by 41 publications

(48 citation statements)

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“…An increased frequency of an Xba I Restriction Fragment Length Polymorphism (RFLP, likelyto be due to 3' flanking region insertions, has been describedin some patients with SLE and elevated IL-6 levels [179]. Byusing polymerase chain reaction (PCR)-RFLP and sensitive polyacrylamide gel electrophoresis, an association between genotype for the 3' flanking region polymorphismand peak bone mineral density in women has been demonstrated [180]. Manipulating the genetic mechanismscontrolling the IL-6 levels and increasing the frequency of GG alleles in the population would prevent aging and age related diseases and be the key to eternal youth and immortality.…”

Section: Aging Age-related Disorders Interleukin-6 and Gene Therapymentioning

confidence: 99%

The Interleukin-6 inflammation pathway from cholesterol to aging – Role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases

Omoigui¹

2007

Immun Ageing

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We describe the inflammation pathway from Cholesterol to Aging. Interleukin 6 mediated inflammation is implicated in age-related disorders including Atherosclerosis, Peripheral Vascular Disease, Coronary Artery Disease, Osteoporosis, Type 2 Diabetes, Dementia and Alzheimer's disease and some forms of Arthritis and Cancer. Statins and Bisphosphonates inhibit Interleukin 6 mediated inflammation indirectly through regulation of endogenous cholesterol synthesis and isoprenoid depletion. Polyphenolic compounds found in plants, fruits and vegetables inhibit Interleukin 6 mediated inflammation by direct inhibition of the signal transduction pathway. Therapeutic targets for the control of all the above diseases should include inhibition of Interleukin-6 mediated inflammation.

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Section: Aging Age-related Disorders Interleukin-6 and Gene Therapymentioning

confidence: 99%

The Interleukin-6 inflammation pathway from cholesterol to aging – Role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases

Omoigui¹

2007

Immun Ageing

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“…IL-6 influences osteoclast function and stimulates bone resorption. 19 Studies have found a link between polymorphisms in the IL-6 gene and BMD in otherwise healthy women 20 and in those with inflammatory bowel disease. 21 Collagen type 1a1 (COL1A1) gene mutations are responsible for the condition osteogenesis imperfecta.…”

mentioning

confidence: 99%

Influence of IL-6, COL1A1, and VDR gene polymorphisms on bone mineral density in Crohn's disease

Todhunter

Sutherland-Craggs²,

Bartram³

et al. 2005

Gut

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Background: Osteoporosis is an important cause of morbidity in patients with Crohn's disease. The pathogenesis of reduced bone mineral density (BMD) is multifactorial. A range of genetic factors have been implicated in other populations of patients with osteoporosis. Aim: To investigate the influence of interleukin 6 (IL-6), collagen type 1a1 (COL1A1), and vitamin D receptor gene (VDR) single nucleotide polymorphisms (SNP) on BMD in patients with Crohn's disease. Patients: A cohort of 245 well characterised patients with Crohn's disease were recruited from the inflammatory bowel disease register at the Freeman Hospital and Royal Victoria Infirmary, Newcastle upon Tyne, and the Queen Elizabeth Hospital, Gateshead, UK. Methods: Patients were genotyped for IL-6 C-174G SNP, COL1A1 Sp1 binding site G T SNP, VDR Taq1, and Fok1 SNPs, and CARD15 R702W, G908R, and L1007fs SNPs. BMD was measured at the lumbar spine (LSP) and hip using dual energy x ray absorptiometry. Results: A total of 158 female and 87 male patients, aged 24-70 years (mean 44), were recruited. There were no significant differences in the distribution of the tested SNPs when analysed for age, body mass index, pre/post-menopausal status, smoking, or steroid use. Two hundred and thirteen patients were genotyped for the IL-6 SNP. LSP and total hip BMD was significantly lower in patients with the GG genotype (48%) than the CC genotype (15%) (p = 0.041, p = 0.014). One hundred and eighty patients were genotyped for the COL1A1 SNP. There was no significant difference in BMD at LSP. Hip BMD was significantly lower in heterozygous patients compared with homozygous wild-types (p = 0.034). There were no significant differences in BMD between genotypes for the two VDR SNPs or the CARD15 genotypes examined. Conclusion: IL-6 and COL1A1 gene polymorphisms influence BMD in patients with Crohn's disease but the particular VDR gene polymorphisms studied do not have a major effect.

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“…We are disappointed, however, that they have not mentioned a few earlier basic studies, viz., by Marcel Simon. In the late 1970s, Simon and his group (4,5) were the rst to show that HH was an autosomal recessive condition. In the ensuing 20 years several university groups searched for the hemochromatosis gene, and in 1996 it was found by a commercial rm (Mercator Genetics, Inc., Menlo Park, Calif., USA).…”

Section: High Prevalence Of Hemochromatosis In Nord-trøndelagmentioning

confidence: 99%

“…Finally, in ammatory cytokines lead to overproduction of nitric oxide, a potential mediator of bone loss that has been examined in arthritis but only to a limited extent in IBD (2). Polymorphisms in the IL-6 gene have been identi ed at the promoter region (-174 G/C) (3) and 3' untranslated region (variable nucleotide repeats) (4,5). These are linked to regulation of bone density by in uencing peak bone mass and resorption rate.…”

mentioning

confidence: 99%

Determinants of Bone Loss in Inflammatory Bowel Disease: a New Role for Interleukin-6 Polymorphisms?

Hurlstone¹

2002

Scandinavian Journal of Gastroenterology

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Polymorphisms of the interleukin-6 gene are associated with bone mineral density

Cited by 41 publications

References 0 publications

The Interleukin-6 inflammation pathway from cholesterol to aging – Role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases

The Interleukin-6 inflammation pathway from cholesterol to aging – Role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases

Influence of IL-6, COL1A1, and VDR gene polymorphisms on bone mineral density in Crohn's disease

Determinants of Bone Loss in Inflammatory Bowel Disease: a New Role for Interleukin-6 Polymorphisms?

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