2002
DOI: 10.1086/344238
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Polymorphisms of the Cytomegalovirus (CMV)–Encoded Tumor Necrosis Factor–α and β‐Chemokine Receptors in Congenital CMV Disease

Abstract: Some congenital cytomegalovirus (CMV) infections lead to neonatal disease, whereas others have no associated sequelae. To explore a possible role for viral genes as determinants of virulence, portions of the UL144 tumor necrosis factor (TNF)-alpha-like receptor gene, the US28 beta-chemokine receptor gene, and the UL55 envelope glycoprotein B gene from 33 patients with congenital CMV infection were sequenced. Three major UL144 subtypes (A, B, and C) and 2 recombinants (A/C and A/B) were detected. Infection with… Show more

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Cited by 94 publications
(145 citation statements)
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“…UL144 genotyping results. The UL144 gene sequences of the 68 samples studied clustered in five genotypes, as previously described by Arav-Boger et al and Lurain et al (1,14) (Fig. 1).…”
Section: Congenital CMV Infection-related Symptoms and Outcomesupporting
confidence: 58%
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“…UL144 genotyping results. The UL144 gene sequences of the 68 samples studied clustered in five genotypes, as previously described by Arav-Boger et al and Lurain et al (1,14) (Fig. 1).…”
Section: Congenital CMV Infection-related Symptoms and Outcomesupporting
confidence: 58%
“…The UL144 protein may therefore contribute to the ability of HCMV to escape immune clearance and may potentially affect its virulence. Phylogenetic analysis shows that nucleotide sequences of the UL144 gene cluster in three major groups (1,4,14). The link between the polymorphism of putative virulence genes, such as the UL144 gene, and the outcome of congenital infection has scarcely been studied.…”
mentioning
confidence: 99%
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“…In an earlier report, we documented the occurrence of CMV reinfection between pregnancies in seropositive women, and such reinfection could lead to intrauterine transmission and symptomatic congenital CMV infection (5). Several other studies have also documented CMV infection with multiple virus strains in a variety of population groups, including children attending day care centers, human immunodeficiency virusinfected individuals, allograft recipients, and infants with congenital CMV infection (1,2,10,14). Together, the findings of these studies of different population groups suggest that infections with multiple CMV strains occur frequently.…”
Section: Discussionmentioning
confidence: 77%
“…Epidemiological studies indicate that specific strains of HCMV preferentially circulate in distinct subpopulations (64), suggesting that UL144 may differentially impact latency and/or host immunity depending upon the specific genetic background of the individual. Notably, conflicting conclusions have been reached when assessing the potential role of UL144 in the outcome of congenital HCMV infection (65)(66)(67)(68)(69), and these studies have been performed with people of differing ethnicities, further suggesting that the impact of UL144 on HCMV pathogenesis may be genetically linked and, as yet, remains unclear.…”
Section: Figmentioning
confidence: 99%