Polymorphisms of the apoptosis-associated gene DP1L1 (deleted in polyposis 1-like 1) in colon cancer and inflammatory bowel disease

Wellmann, Axel; Fogt, Franz; Hollerbach, Stephan; Hahne, Jens C.; Koenig-Hoffmann, Kerstin; Smeets, Daniela; Brinkmann, Ulrich

doi:10.1007/s00432-009-0719-9

Cited by 6 publications

(2 citation statements)

References 21 publications

(37 reference statements)

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“…A genetic study reporting the association among polymorphisms of the apoptosis-associated gene DP1L1, colon cancer, and IBD may shed light on the underlying mechanisms. 24 To our knowledge, a worse prognosis of other cancer with IBD observed in the present study has not been reported before.…”

Section: Discussionmentioning

confidence: 56%

Survival in cancer patients hospitalized for inflammatory bowel disease in Sweden

Shu

Sundquist

et al. 2011

Inflammatory Bowel Diseases

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Section: Discussionmentioning

confidence: 56%

Survival in cancer patients hospitalized for inflammatory bowel disease in Sweden

Shu

Sundquist

et al. 2011

Inflammatory Bowel Diseases

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“…A few studies have examined the potential roles of REEP6 in various types of cancer. For example, REEP6 polymorphisms at positions 992 and 996 have been associated with colon cancer [20], and low levels of REEP6 are significantly correlated with reduced cell growth and invasion in lung cancer cells [21]. However, its role in TSCC has not been studied.…”

Section: Discussionmentioning

confidence: 99%

The Clinical and Biological Effects of Receptor Expression-Enhancing Protein 6 in Tongue Squamous Cell Carcinoma

et al. 2023

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There are currently no effective biomarkers for the diagnosis and treatment of tongue squamous cell carcinoma (TSCC), which causes a poor 5-year overall survival rate. Thus, it is crucial to identify more effective diagnostic/prognostic biomarkers and therapeutic targets for TSCC patients. The receptor expression-enhancing protein 6 (REEP6), a transmembrane endoplasmic reticulum resident protein, controls the expression or transport of a subset of proteins or receptors. Although it was reported that REEP6 plays a role in lung and colon cancers, its clinical impact and biological role in TSCC are still unknown. The present study aimed to identify a novel effective biomarker and therapeutic target for TSCC patients. Expression levels of REEP6 in specimens from TSCC patients were determined with immunohistochemistry. Gene knockdown was used to evaluate the effects of REEP6 in cancer malignancy (colony/tumorsphere formation, cell cycle regulation, migration, drug resistance and cancer stemness) of TSCC cells. The clinical impact of REEP6 expression and gene co-expression on prognosis were analyzed in oral cancer patients including TSCC patients from The Cancer Genome Atlas database. Tumor tissues had higher levels of REEP6 compared to normal tissues in TSCC patients. Higher REEP6 expression was related to shorter disease-free survival (DFS) in oral cancer patients with poorly differentiated tumor cells. REEP6-knocked-down TSCC cells showed diminished colony/tumorsphere formation, and they also caused G1 arrest and decreased migration, drug resistance and cancer stemness. A high co-expression of REEP6/epithelial–mesenchymal transition or cancer stemness markers also resulted in poor DFS in oral cancer patients. Thus, REEP6 is involved in the malignancy of TSCC and might serve as a potential diagnostic/prognostic biomarker and therapeutic target for TSCC patients.

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Whole-transcriptome analysis of mouse adipose tissue in response to short-term caloric restriction

et al. 2015

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Caloric restriction (CR) has been shown to extend the lifespan of many species by improving cellular function and organismal health. Additionally, fat reduction by CR may play an important role in lengthening lifespan and preventing severe age-related diseases. Interestingly, CR induced the greatest transcriptome change in the epididymal fat of mice in our study. In this transcriptome analysis, we identified and categorized 446 genes that correlated with CR level. We observed down-regulation of several signaling pathways, including insulin/insulin-like growth factor 1 (insulin/IGF-1), epidermal growth factor (EGF), transforming growth factor beta (TGF-β), and canonical wingless-type mouse mammary tumor virus integration site (Wnt). Many genes related to structural features, including extracellular matrix structure, cell adhesion, and the cytoskeleton, were down-regulated, with a strong correlation to the degree of CR. Furthermore, genes related to the cell cycle and adipogenesis were down-regulated. These biological processes are well-identified targets of insulin/IGF-1, EGF, TGF-β, and Wnt signaling. In contrast, genes involved in specific metabolic processes, including the tricarboxylic acid cycle and the electron transport chain were up-regulated. We performed in silico analysis of the promoter sequences of CR-responsive genes and identified two associated transcription factors, Paired-like homeodomain 2 (Pitx2) and Paired box gene 6 (Pax6). Our results suggest that strict regulation of signaling pathways is critical for creating the optimal energy homeostasis to extend lifespan.

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Polymorphisms of the apoptosis-associated gene DP1L1 (deleted in polyposis 1-like 1) in colon cancer and inflammatory bowel disease

Abstract: DP1L1 polymorphisms are associated with colon cancer and IBD. This indicates that DP1L1 plays a functional role in these conditions. Thus DP1L1 may be a diagnostic and therapeutic target for colon cancer and IBD.

Cited by 6 publications

References 21 publications

Survival in cancer patients hospitalized for inflammatory bowel disease in Sweden

Survival in cancer patients hospitalized for inflammatory bowel disease in Sweden

The Clinical and Biological Effects of Receptor Expression-Enhancing Protein 6 in Tongue Squamous Cell Carcinoma

Whole-transcriptome analysis of mouse adipose tissue in response to short-term caloric restriction

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