Polymorphisms of the Aldose Reductase Locus (ALR2) and Susceptibility to Diabetic Microvascular Complications

Patel, Ashok Kumar; Ratanachaiyavong, Suvina; Ba, Millward; Ag, Demaine

doi:10.1007/978-1-4615-2904-0_34

Cited by 23 publications

(9 citation statements)

References 22 publications

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“…This SNP occurs at the 95 th nucleotide of intron 8 and is the BamHI restriction endonuclease site that had previously been reported by Patel [88,102]. This polymorphism is strongly associated with diabetic retinopathy in adolescent T1DM subjects of Caucasoid (Australia) origin.…”

Section: A(+11842)cmentioning

confidence: 80%

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Polymorphisms of the Aldose Reductase Gene and Susceptibility to Diabetic Microvascular Complications

Ag¹

2003

CMC

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Diabetes is a major cause of mortality and morbidity due to the long term microvascular complications of this disease. There is now convincing evidence to show that genetic factors together with elevated blood glucose play an important role in the susceptibility to diabetic nephropathy as well as retinopathy. The polyol pathway is thought to play an important role in the pathogenesis of diabetic microvascular complications. Aldose reductase is the first and rate-limiting enzyme of the polyol pathway. Polymorphisms in the promoter region as well as elsewhere in the gene have been associated with susceptibility to nephropathy, retinopathy as well as diabetic neuropathy. These associations have been replicated in patients with either type 1 or type 2 diabetes mellitus as well as across ethnic groups. These polymorphisms in the promoter region are also associated with expression of the gene. Although clinical trials using inhibitors of aldose reductase to treat diabetic microvascular complications have largely been unsuccessful, the identification of the susceptibility genes may help in the design of future drug regimens.

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Section: A(+11842)cmentioning

confidence: 80%

“…The first polymorphisms in the ALR2 gene were identified in 1993 [88]. Using the 5' and 3' regions of the ALR2 cDNA sequence as probes, a BamHI/RFLP in the 3' end as well as a PstI RFLP in the 5' end of the gene were identified.…”

Section: Polymorphisms Of the Aldose Reductase (Alr2) Genementioning

confidence: 99%

Polymorphisms of the Aldose Reductase Gene and Susceptibility to Diabetic Microvascular Complications

Ag¹

2003

CMC

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“…The AR gene has been proposed as a candidate gene for the development of late diabetic complications [7]. A recent study of 75 Type I diabetic patients with diabetic nephropathy and 38 without, found that patients with the Z-2 allele were at high risk for diabetic nephropathy whereas those with the Z + 2 allele were protected from this complication [4].…”

Section: Discussionmentioning

confidence: 99%

The role of aldose reductase gene in the susceptibility to diabetic nephropathy in Type II (non-insulin-dependent) diabetes mellitus (Short Communication)

et al. 1999

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“…It extends over approximately 18 kb and consists of 10 exons[18]. Several restriction fragment length polymorphisms (RFLPs) have been identified in this gene, and positive associations with diabetic microvascular complications for some of these have been reported[8–10]. None of these polymorphisms result in amino acid changes of the protein[8,9–10].…”

Section: Introductionmentioning

confidence: 99%

Aldose reductase gene polymorphisms and susceptibility to diabetic nephropathy in Type 1 diabetes mellitus

et al. 2000

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Polymorphisms of the Aldose Reductase Locus (ALR2) and Susceptibility to Diabetic Microvascular Complications

Cited by 23 publications

References 22 publications

Polymorphisms of the Aldose Reductase Gene and Susceptibility to Diabetic Microvascular Complications

Polymorphisms of the Aldose Reductase Gene and Susceptibility to Diabetic Microvascular Complications

The role of aldose reductase gene in the susceptibility to diabetic nephropathy in Type II (non-insulin-dependent) diabetes mellitus (Short Communication)

Aldose reductase gene polymorphisms and susceptibility to diabetic nephropathy in Type 1 diabetes mellitus

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