Polymorphisms of pro-opiomelanocortin gene and the association with reproduction traits in chickens

Liu, Ke; Cao, Haiyue; Dong, Xin; Liu, Honghua; Wen, Yaya; Mao, Haoyu; Lu, Linwei; Yin, Zhaozheng

doi:10.1016/j.anireprosci.2019.106196

Cited by 3 publications

(4 citation statements)

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“…POMC (pro-opiomelanocortin) is a member of the prohormone family and has an important function in regulating energy balance and reproduction [ 37 ]. A recent study reported that the POMC gene had potential effects on reproduction traits in chickens [ 38 ]. GALR1 (galanin type I receptor) is widely expressed in the chicken small intestine, kidney, ovary, pancreas, spleen and throughout the oviduct.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome analysis of ovary tissues from low- and high-yielding Changshun green-shell laying hens

Gegen

et al. 2021

BMC Genomics

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Background Changshun green-shell laying hens are unique to Guizhou Province, China, and have high egg quality. Improving egg production performance has become an important breeding task, and in recent years, the development of high-throughput sequencing technology provides a fast and exact method for genetic selection. Therefore, we aimed to use this technology to analyze the differences between the ovarian mRNA transcriptome of low and high-yield Changshun green-shell layer hens, identify critical pathways and candidate genes involved in controlling the egg production rate, and provide basic data for layer breeding. Results The egg production rates of the low egg production group (LP) and the high egg production group (HP) were 68.00 ± 5.56 % and 93.67 ± 7.09 %, with significant differences between the groups (p < 0.01). Moreover, the egg weight, shell thickness, strength and layer weight of the LP were significantly greater than those of the HP (p < 0.05). More than 41 million clean reads per sample were obtained, and more than 90 % of the clean reads were mapped to the Gallus gallus genome. Further analysis identified 142 differentially expressed genes (DEGs), and among them, 55 were upregulated and 87 were downregulated in the ovaries. KEGG pathway enrichment analysis identified 9 significantly enriched pathways, with the neuroactive ligand-receptor interaction pathway being the most enriched. GO enrichment analysis indicated that the GO term transmembrane receptor protein tyrosine kinase activity, and the DEGs identified in this GO term, including PRLR, NRP1, IL15, BANK1, NTRK1, CCK, and HGF may be associated with crucial roles in the regulation of egg production. Conclusions The above-mentioned DEGs may be relevant for the molecular breeding of Changshun green-shell laying hens. Moreover, enrichment analysis indicated that the neuroactive ligand-receptor interaction pathway and receptor protein tyrosine kinases may play crucial roles in the regulation of ovarian function and egg production.

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Section: Discussionmentioning

confidence: 99%

Transcriptome analysis of ovary tissues from low- and high-yielding Changshun green-shell laying hens

Gegen

et al. 2021

BMC Genomics

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“…Recent studies demonstrated that melatonin could directly modulate bovine ovarian function through MTNR1B, melatonin and MTNR1B are involved in the BCL2 family and apoptotic pathways in bovine granulosa cells (Liu et al., 2018; Wang, Liu, Ahmad, et al, 2012; Wang, Liu, Wu, et al, 2012). Besides, polymorphisms of MTNR1B gene have a great influence on the egg reproduction trait in avian species, such as chicken (Li et al., 2012; Zhao et al., 2014), duck (Feng et al., 2018) and goose (Alsiddig et al., 2016). However, no data have been reported about polymorphism on MTNR1B and its correlation with ovine reproductive seasonality and litter size.…”

Section: Discussionmentioning

confidence: 99%

The effect of SNP rs400827589 in exon 2 of the MTNR1B gene on reproductive seasonality and litter size in sheep

Zhang

Chu

2020

Veterinary Medicine & Sci

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In mammals, the melatonin receptor gene has been widely studied since it has a great influence on reproductive traits. However, little is known about the association between polymorphism of the coding region of the MTNR1B gene and year‐round oestrus or the litter size in Small Tail Han sheep. To better understand the effects of single nucleotide polymorphism (SNP) rs400827589 in MTNR1B, a population polymorphism analysis was conducted using genotyping data in 45 sheep breeds around the world. The results indicated that TT was the dominant genotype in all sheep breeds. The associations of this SNP with reproductive seasonality and litter size in Small Tail Han sheep showed rs400827589 was correlated with fecundity as assessed by reproductive seasonality and litter size (p < .05). Bioinformatics analysis indicated the change in amino acid from Ile to Leu may affect the function of the MTNR1B protein by impacting the secondary and tertiary protein structures. The present results demonstrate that rs400827589 could be used in the marker‐assisted selection of the litter size in Small Tail Han sheep.

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“…All the experimental procedures and protocol used during this experiment were approved by the Animal Science College of Zhejiang University (Hangzhou, China), on the care and use of experimental animals. A total of 648, 23-week-old healthy broiler breeders of native dual-purpose breed ZhenNing ( Liu et al., 2019 ), with uniform body weight (1.40 ± 0.002 kg), were used in the feeding trial that lasted for 14 wk (including 2 wk for adaptation). Experimental birds were divided into 4 groups ( Cont., Mix, M-TOM, and L-TOM ); each group consists of 6 replicates (27 hens/replicate) and 3 hens were kept in a cage (cage dimensions: 50 × 50 × 50 cm 3 ).…”

Section: Methodsmentioning

confidence: 99%

“…Twenty qualified eggs per replicate (total 480) were randomly collected at the third, sixth, ninth, and 12th wk, respectively, for hatching (total 1,920). Incubation was done in a commercial incubator with automatic egg turning at 37°C and 65 to 75% relative humidity ( Liu et al., 2019 ). On day 19, no.…”

Section: Methodsmentioning

confidence: 99%

Effects of inorganic trace minerals replaced by complexed glycinates on reproductive performance, blood profiles, and antioxidant status in broiler breeders

et al. 2020

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This study was conducted to investigate the effects of replacing inorganic trace minerals ( ITM ) with organic trace minerals ( OTM ; complexed glycinates) on reproductive performance, blood profiles, and antioxidant status in broiler breeders. A total of 648, 23-week-old healthy broiler breeders (ZhenNing), with similar body weight (1.40 ± 0.002 kg), were randomly divided into 4 groups with 6 replicates in each group (27 hens/replicate) and fed the respective experimental diets for 14 wk (including 2 wk for adaptation). The experimental treatments consisted of T1: Cont., commercially recommended levels of ITM (Cu, Zn, Fe, and Mn sulfates); T2: Mix, half trace minerals ( TM ) were provided from ITM and half from OTM (glycinates); T3: M-OTM, TM were provided from glycinates and reduced to 70% of T1; T4: L-OTM, TM were provided from glycinates and reduced to 50% of T1. The results showed that commercial level of inorganic trace minerals replaced by low-dose complexed glycinates (T3 and T4) exhibited no significant effects on laying performance, 50% ITM replaced by complexed glycinates (T2) numerically improved laying rate by 1.23% than cont. treatment (T1). Broiler breeders fed complexed glycinates tended to produce more qualified eggs ( P = 0.05) in T3, with better yolk color ( P < 0.01) and eggshell thickness ( P = 0.05) in T2 treatment. Replacement of low-dose complexed glycinates reduced fertilization rate ( P < 0.01), while it did not affect hatchability. There were no significant differences in serum reproductive hormones such as estrogen and progesterone among the treatments. Serum total protein, albumin, and phosphorus were increased respectively with the replacement of ITM by low-dose OTM from complexed glycinates ( P < 0.05). Total liver antioxidant capacity in M-OTM and L-OTM treatment was higher than that of Cont. and Mix treatments ( P < 0.01). In conclusion, replacement of high levels of ITM by lower levels of OTM in the form of complexed glycinates is beneficial for egg quality and liver antioxidant status in broiler breeders during the peak laying period.

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Polymorphisms of pro-opiomelanocortin gene and the association with reproduction traits in chickens

Cited by 3 publications

References 27 publications

Transcriptome analysis of ovary tissues from low- and high-yielding Changshun green-shell laying hens

Transcriptome analysis of ovary tissues from low- and high-yielding Changshun green-shell laying hens

The effect of SNP rs400827589 in exon 2 of the MTNR1B gene on reproductive seasonality and litter size in sheep

Effects of inorganic trace minerals replaced by complexed glycinates on reproductive performance, blood profiles, and antioxidant status in broiler breeders

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