Polymorphisms of KAP6, KAP7, and KAP8 genes in four Chinese sheep breeds

Liu, Y.X.; Guo-qing, Shi; Wang, H.X.; Wan, Peng; Tang, Hong; Yang, Heng; Gao, Feng

doi:10.4238/2014.april.30.5

Cited by 16 publications

(16 citation statements)

References 21 publications

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“…It is consistent with Liu et al . ’s 10 finding of DNA sequences that appeared to be different to the known KAP6-1 and KAP6-2 sequences, but we chose not to use the sequences they report in our phylogenetic analysis. This decision was made because the approach Liu et al .…”

Section: Discussionmentioning

confidence: 99%

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Identification of four new gene members of the KAP6 gene family in sheep

Zhou

Gong

Wang

et al. 2016

Sci Rep

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KAP6 is a high glycine-tyrosine keratin-associated protein (HGT-KAP) family. This family is thought to contain multiple genes. In this study, we used a KRTAP6 coding sequence to search the Ovine Genome (v3.1) and identified five homologous regions (R1–R5). All these regions contained an open reading frame, and they were either identical to, or highly similar to, sheep skin Expressed Sequence Tags (ESTs). Phylogenetic analysis revealed that R1–R5 were clustered with KAP6 sequences from different species and formed a group distinct to other HGT-KAPs. R1 was very similar to the characterised KRTAP6-1 sequence, but the remaining genes appeared to be new. PCR primers were designed to amplify and confirm the presence of these new genes. Amplicons were obtained for all of the 96 sheep investigated. Six, five, three and six PCR-SSCP patterns representing six, five, three and six DNA sequences were observed for KRTAP6-2 to KRTAP6-5 respectively. KRTAP6-2 and KRTAP6-4 had five and three SNPs respectively. Three SNPs and a 45-bp insertion/deletion were detected for KRTAP6-3, and five SNPs and an 18-bp insertion/deletion were identified for KRTAP6-5. Allele frequencies for these KAP6 genes differed between Merino and Romney sheep.

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Section: Discussionmentioning

confidence: 99%

“…To date only one gene ( KRTAP6-1 ) has been characterised 8 , although the presence of three putative KAP6 genes has been suggested based on sequence analysis of amplified KRTAP6 -like sequences 9 and more recently Liu et al . 10 , also suggest the presence of more than one KAP6 gene.…”

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confidence: 99%

Identification of four new gene members of the KAP6 gene family in sheep

Zhou

Gong

Wang

et al. 2016

Sci Rep

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“…Selection for higher prolificacy in domestic sheep ( Ovis aries ) has led to variable litter size (LS) within and among breeds. For example, individual litter size of 1 to 8 has been recorded in the Hu sheep and Finnsheep ( Yue, 1996 ; Davis et al, 2006a ).…”

Section: Introductionmentioning

confidence: 99%

Genome-Wide Association Analyses Highlight the Potential for Different Genetic Mechanisms for Litter Size Among Sheep Breeds

Gao

Xie

et al. 2018

Front. Genet.

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Reproduction is an important trait in sheep breeding as well as in other livestock. However, despite its importance the genetic mechanisms of litter size in domestic sheep (Ovis aries) are still poorly understood. To explore genetic mechanisms underlying the variation in litter size, we conducted multiple independent genome-wide association studies in five sheep breeds of high prolificacy (Wadi, Hu, Icelandic, Finnsheep, and Romanov) and one low prolificacy (Texel) using the Ovine Infinium HD BeadChip, respectively. We identified different sets of candidate genes associated with litter size in different breeds: BMPR1B, FBN1, and MMP2 in Wadi; GRIA2, SMAD1, and CTNNB1 in Hu; NCOA1 in Icelandic; INHBB, NF1, FLT1, PTGS2, and PLCB3 in Finnsheep; ESR2 in Romanov and ESR1, GHR, ETS1, MMP15, FLI1, and SPP1 in Texel. Further annotation of genes and bioinformatics analyses revealed that different biological pathways could be involved in the variation in litter size of females: hormone secretion (FSH and LH) in Wadi and Hu, placenta and embryonic lethality in Icelandic, folliculogenesis and LH signaling in Finnsheep, ovulation and preovulatory follicle maturation in Romanov, and estrogen and follicular growth in Texel. Taken together, our results provide new insights into the genetic mechanisms underlying the prolificacy trait in sheep and other mammals, suggesting targets for selection where the aim is to increase prolificacy in breeding projects.

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“…Thus, synthesis of wool may be linked to lipid metabolism [11]. However, studies on wool traits and regulation mechanisms have been mostly concentrated on the proteins, especially Keratin intermediate filament (KRT-IF) and Keratin-associated proteins (KAPs) [12–14]. The relationship between wool lipids and wool traits, however, has not been examined in detail.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome Analysis Reveals Skin Lipid Metabolism Related to Wool Diameter in Sheep

et al. 2016

Preprint

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Precise characterization of biological processes critical to proliferation and metastasis of colorectal cancer should facilitate the development of diagnostic and prognostic biomarkers as well as novel treatments. Using mRNA-Seq, we examined the protein coding messenger RNA (mRNA) expression profiles across different histologically defined stages of primary colon cancers and compared them to their patient matched normal tissue controls. In comparing 79 colorectal cancers to their matched normal mucosa, tumors were distinguished from normal non-malignant tissues not only in the upregulation of biological processes pertaining to cell proliferation, inflammation, and tissue remodeling, but even more strikingly, in downregulated biological processes including fatty acid beta oxidization for ATP production and epithelial cell differentiation and function. A network analysis of deregulated genes revealed newly described cancer networks and putative hub genes. Taken together, our findings suggest that, within an inflammatory microenvironment, invasive, dedifferentiated and rapidly dividing tumor cells divert the oxidation of fatty acids and lipids from energy production into lipid components of cell membranes and organelles to support tumor proliferation. A gene co-expression network analysis provides a clear and broad picture of biological pathways in tumors that may significantly enhance or supplant current histopathologic studies.

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Polymorphisms of KAP6, KAP7, and KAP8 genes in four Chinese sheep breeds

Cited by 16 publications

References 21 publications

Identification of four new gene members of the KAP6 gene family in sheep

Identification of four new gene members of the KAP6 gene family in sheep

Genome-Wide Association Analyses Highlight the Potential for Different Genetic Mechanisms for Litter Size Among Sheep Breeds

Transcriptome Analysis Reveals Skin Lipid Metabolism Related to Wool Diameter in Sheep

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