Polymorphisms of insulin receptor substrate 1 and β3-adrenergic receptor genes in gestational diabetes and normal pregnancy

Fallucca, F; Dalfrà, Maria Grazia; Sciullo, E.; Masin, M.; Buongiorno, A.; Napoli, Angela; Fedele, Domenico; Lapolla, Annunziata

doi:10.1016/j.metabol.2006.06.004

Cited by 43 publications

(46 citation statements)

References 28 publications

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“…37 The Arg64 allele frequency was also comparable between 309 white women with GDM and 277 women with normal glucose tolerance. 63 Similar findings were obtained by Tsai et al 88 in a cohort of 299 Taiwanese women: 258 with normal glucose tolerance and 41 with GDM. Although Arg64 carriers with GDM had higher fasting and 120-minute postload insulin levels than did homozygotes for the wild-type allele, the Arg64 allele frequency was similar in the control and the GDM groups (0.145 vs. 0.098, P ϭ 0.086).…”

Section: ␤-3 Adrenergic Receptor (Adrb3)supporting

confidence: 78%

“…62 Considering the role of IRS1 in insulin signaling, the Gly972Arg polymorphism was investigated in association with GDM. Fallucca et al 63 observed that the frequency of the IRS1 Arg972 allele was higher in 309 white women with GDM than in 277 with normal glucose tolerance. Conversely, Shaat et al 24 observed a similar 972Arg allele frequency in 588 Scandinavian women having GDM and 1189 nondiabetic pregnant controls (4.8% compared with 4.7%, OR: 1.04, 95% CI: 0.75-1.44).…”

Section: Insulin Receptor Substrate 1 (Irs1)mentioning

confidence: 99%

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The genetics of gestational diabetes mellitus: evidence for relationship with type 2 diabetes mellitus

Robitaille

Grant

2008

Genetics in Medicine

130

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Gestational diabetes is a major public health problem because of its prevalence, its associated complications during pregnancy, and its increased risk for type 2 diabetes later in life. Insulin resistance is one of many physiological changes occurring during pregnancy, and when insulin resistance is accompanied by pancreatic ␤-cell insufficiency, gestational diabetes may develop. Several lines of evidence suggest that gestational diabetes shares a common etiology with type 2 diabetes and support the hypothesis that gestational diabetes serves as a window to reveal a predisposition to type 2 diabetes. Pregnancy is an environmental stressor that may catalyze the progression to a diabetic state in genetically predisposed women; therefore, identification of these women during pregnancy could decrease the occurrence of type 2 diabetes through targeted prevention. This review presents an overview of the genetics of gestational diabetes, focusing on human association studies with candidate genes common to both type 2 diabetes and gestational diabetes. Genet Med 2008:10(4):240 -250. Key Words: gestational diabetes mellitus, type 2 diabetes, genetics, pregnancy, association studiesGestational diabetes mellitus (GDM) is a major public health problem because of its prevalence and its associated complications during pregnancy. It is estimated that 4% of pregnancies in the United States are complicated by GDM, although the prevalence of GDM varies considerably among racial and ethnic groups. 1 Uncontrolled GDM increases the risk of adverse neonatal outcomes such as macrosomia, birth injuries, neonatal hypoglycemia, neonatal cardiac dysfunction, and stillbirth. 2 In addition to increasing the risk of adverse infant outcomes, GDM also has high predictive value for later development of type 2 diabetes (T2D) in the mother and in her offspring. Women who experience GDM have increased risk of developing T2D after pregnancy, ranging from 17% to 63% within 5-16 years after pregnancy depending on the population and other risk factors. 3 Additionally, offspring of mothers with GDM are more likely to be obese and display impaired glucose tolerance during adolescence than are offspring of nondiabetic mothers. Thus, diabetes during pregnancy is not only associated with the later risk of diabetes in mothers but also with metabolic changes that may lead to the development of diabetes in their offspring. 4 This observed connection between GDM and risk of T2D strongly suggests that GDM can serve as a window revealing a predisposition to T2D, with pregnancy as the environmental stressor that catalyzes progression to a diabetic state in predisposed individuals. 5 Several lines of evidence support the above hypothesis. First, GDM shares several risk factors with T2D, including high body mass index (BMI), history of abnormal glucose tolerance, diabetes in a first-degree relative, and membership in an ethnic group with a high risk of T2D. 6 Second, GDM and T2D share similar pathophysiologies: women undergo major physiological changes during pregn...

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Section: ␤-3 Adrenergic Receptor (Adrb3)supporting

confidence: 78%

Section: Insulin Receptor Substrate 1 (Irs1)mentioning

confidence: 99%

The genetics of gestational diabetes mellitus: evidence for relationship with type 2 diabetes mellitus

Robitaille

Grant

2008

Genetics in Medicine

130

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“…Analysis of subsequent studies has shown an association of this polymorphism with features of the metabolic syndrome [40]. In addition, the Trp64Arg polymorphism has been associated with 'mild' gestational diabetes mellitus in Austrian [25], but not in Greek [26], Taiwanese [27] or Italian [28] women. However, it was associated with increased weight gain and increased glucose and insulin levels during pregnancy [25,27].…”

Section: Adrb3 Trp64argmentioning

confidence: 99%

“…These polymorphisms were the transcription factor 7-like 2 (TCF7L2 rs7903146) [12][13][14][15][16][17][18][19], adiponectin (ADIPOQ +276G>T) [20,21], peroxisome-proliferator activated receptor (PPAR), gamma 2 (PPARG Pro12Ala) [22], PPARG-coactivator 1, alpha (PPARGC1A Gly482Ser) [23] and forkhead box C2 (FOXC2 −512C>T) [24]. Despite its MAF~10%, we also included the β3-adrenergic receptor (ADRB3 Trp64Arg) polymorphism, as its putative association with gestational diabetes mellitus has been addressed in a number of small studies with inconsistent results [25][26][27][28]. These polymorphisms were genotyped in a case-control study of 1,881 unrelated pregnant Scandinavian women (649 with gestational diabetes mellitus, 1,232 non-diabetic control subjects).…”

Section: Introductionmentioning

confidence: 99%

A variant in the transcription factor 7-like 2 (TCF7L2) gene is associated with an increased risk of gestational diabetes mellitus

et al. 2007

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Aims/hypothesis Genetic and epidemiological studies suggest an association between gestational diabetes mellitus and type 2 diabetes. Both are polygenic multifactorial disorders characterised by beta cell dysfunction and insulin resistance. Our aim was to investigate whether common genetic variants that have previously been associated with type 2 diabetes or related phenotypes would also confer risk for gestational diabetes mellitus. Materials and methods In 1,881 unrelated pregnant Scandinavian women (649 women with gestational diabetes mellitus, 1,232 non-diabetic control subjects) we genotyped the transcription factor 7-like 2 (TCF7L2 rs7903146), adiponectin (ADIPOQ +276G>T), peroxisome-proliferator activated receptor, gamma 2 (PPARG Pro12Ala), PPARGcoactivator, 1 alpha (PPARGC1A Gly482Ser), forkhead box C2 (FOXC2 −512C > T) and β3-adrenergic receptor (ADRB3 Trp64Arg) polymorphisms using TaqMan allelic discrimination assay or RFLP.

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“…Insulin receptor substrate 1 (IRS-1) gene has been suggested significantly by playing a role in susceptibility to T2D (4). Offered that the polymorphism in the IRS-1 gene have been contributed in obesity and T2D (5). IRS-1 could have a central role in the insulin-signaling pathway (4).…”

Section: Introductionmentioning

confidence: 99%

Association of Perilipin and Insulin Receptor Substrate-1 Genes Polymorphism with Lipid Profiles, Central Obesity, and Type 2 Diabetes in a Sample of an Iranian Population

Saravani

Noorzehi

Galavi

et al. 2017

Iran Red Crescent Med J

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Background: Since insulin receptor substrate-1 (IRS-1) is the main substrate of the insulin receptor tyrosine kinase and has been detected to activate phosphatidylinositol (PI) 3-kinase and promote GLUT4 translocation, the IRS-1 gene is a possible candidate for development of type2 diabetes, insulin resistance, and obesity. Preilipin (PLIN) coats intracellular lipid droplets and modulates adipocyte lipolysis. Objectives: In this study, we investigated whether insulin receptor substrate-1 (IRS-1) and Perilipin (PLIN) genes polymorphism were associated with Type 2 diabetes (T2D), obesity, and lipid profiles in a sample of the Iranian population (Southeast of Iran). Methods: In this randomized case-control study (Feb, 2016

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Polymorphisms of insulin receptor substrate 1 and β3-adrenergic receptor genes in gestational diabetes and normal pregnancy

Cited by 43 publications

References 28 publications

The genetics of gestational diabetes mellitus: evidence for relationship with type 2 diabetes mellitus

The genetics of gestational diabetes mellitus: evidence for relationship with type 2 diabetes mellitus

A variant in the transcription factor 7-like 2 (TCF7L2) gene is associated with an increased risk of gestational diabetes mellitus

Association of Perilipin and Insulin Receptor Substrate-1 Genes Polymorphism with Lipid Profiles, Central Obesity, and Type 2 Diabetes in a Sample of an Iranian Population

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