Polymorphisms of<i>Methionine Synthase</i>and<i>Methionine Synthase Reductase</i>and Risk of Squamous Cell Carcinoma of the Head and Neck: a Case-Control Analysis

Zhang, Zhengdong; Shi, Qiuling; Liu, Zhensheng; Sturgis, Erich M.; Spitz, Margaret R.; Wei, Qingyi

doi:10.1158/1055-9965.epi-04-0501

Cited by 57 publications

(44 citation statements)

References 28 publications

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“…The results also show that men with head and neck cancer had a higher frequency of the G polymorphic allele than men with no history of cancer, thus supporting the results of Kruszyna et al (24), who showed that the frequency of the G allele was 1.55 times higher in male patients with laryngeal cancer compared to male controls. Our findings did not confirm those of Zhang and et al (22), who reported that the MTR 2756AG genotype is associated with an increased risk for this type of cancer, especially in younger individuals, women and former smokers.…”

Section: Discussioncontrasting

confidence: 99%

“…Our study did not detect any associations of the MTR A2756G polymorphism with the site of occurrence, aggressiveness, tumor extension, or lymph node involvement. Zhang et al (22) showed an increased frequency of the polymorphism related to tumors of the oral cavity, while Kruzsyna et al (24) did not find any association of this polymorphism with laryngeal cancer. After an exhaustive literature review, no previous studies were found regarding the possible association between this polymorphism and clinical histopathological parameters or with the risk of cancer development.…”

Section: Discussionmentioning

confidence: 97%

“…Zhang et al (22) and Kruszyna et al (24) reported differences in the MTR A2756G genotype frequencies between head and neck cancer patients and controls and between larynx cancer patients and controls, respectively, while Suzuki et al (23) did not observe any association between the presence of the polymorphism and the risk for the disease. The latter investigators demonstrated an interaction of alcohol consumption with the 2756GG genotype in the risk for head and neck cancer.…”

Section: Discussionmentioning

confidence: 98%

“…Only three studies have investigated this polymorphism regarding head and neck cancer (22)(23)(24). Zhang et al (22) and Kruszyna et al (24) reported differences in the MTR A2756G genotype frequencies between head and neck cancer patients and controls and between larynx cancer patients and controls, respectively, while Suzuki et al (23) did not observe any association between the presence of the polymorphism and the risk for the disease.…”

Section: Discussionmentioning

confidence: 99%

“…Zhang et al (22), when analyzing the MTR A2756G polymorphism in 721 cancer patients and 1234 control individuals, observed differences in the genotype frequencies between the two groups. They also showed that the 2756AG genotype was associated with a significantly increased risk of HNSCC among younger subjects, women and former drinkers, in particular tumors of the oral cavity.…”

Section: Introductionmentioning

confidence: 99%

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5-Methyltetrahydrofolate-homocysteine methyltransferase gene polymorphism (MTR) and risk of head and neck cancer

Galbiatti

Ruiz

Biselli-Chicote

et al. 2010

Braz J Med Biol Res

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The functional effect of the A>G transition at position 2756 on the MTR gene (5-methyltetrahydrofolate-homocysteine methyltransferase), involved in folate metabolism, may be a risk factor for head and neck squamous cell carcinoma (HNSCC). The frequency of MTR A2756G (rs1805087) polymorphism was compared between HNSCC patients and individuals without history of neoplasias. The association of this polymorphism with clinical histopathological parameters was evaluated. A total of 705 individuals were included in the study. The polymerase chain reaction-restriction fragment length polymorphism technique was used to genotype the polymorphism. For statistical analysis, the chi-square test (univariate analysis) was used for comparisons between groups and multiple logistic regression (multivariate analysis) was used for interactions between the polymorphism and risk factors and clinical histopathological parameters. Using univariate analysis, the results did not show significant differences in allelic or genotypic distributions. Multivariable analysis showed that tobacco and alcohol consumption (P < 0.05), AG genotype (P = 0.019) and G allele (P = 0.028) may be predictors of the disease and a higher frequency of the G polymorphic allele was detected in men with HNSCC compared to male controls (P = 0.008). The analysis of polymorphism regarding clinical histopathological parameters did not show any association with the primary site, aggressiveness, lymph node involvement or extension of the tumor. In conclusion, our data provide evidence that supports an association between the polymorphism and the risk of HNSCC.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

5-Methyltetrahydrofolate-homocysteine methyltransferase gene polymorphism (MTR) and risk of head and neck cancer

Galbiatti

Ruiz

Biselli-Chicote

et al. 2010

Braz J Med Biol Res

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Charge density effects on polyelectrolyte dynamic rheology

Harrington

2007

J of Applied Polymer Sci

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The dynamic rheological properties of an uncharged polymer and charged polyelectrolytes were evaluated in salt-free water at various concentrations above the entanglement concentration. A poly(acrylic acid) homopolymer was used as the uncharged polymer and was ionized to anionic poly(acrylic acid-co-sodium acrylate) at five levels of ionization (0.05, 0.10, 0.15, 0.30, and 0.50). The polymers exhibited a terminal region at a low frequency and a plateau region at a high frequency. The dynamic data for the nonionic parent and all charged polymers could be reduced to a master curve, which indicated a similar distribution of relaxation times for the nonionic and charged polymers. The shear modulus, relaxation time, and zero shear viscosity properties exhibited a concentration and charge density dependence. Higher power-law exponents for the rheological properties were noted for the nonionic polymer versus the charged derivatives. The number of mechanically active entanglements per number of chains increased with the polymer concentration and charge density. The total number of mechanically active entanglements per number of chains that occurred because of imposing a charge to the nonionic parent did not change with increased concentration, and this indicated a different entanglement mechanism for charged polymers in comparison with their nonionic parent.

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Cocaine use and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

Zhang,

Chen,

et al. 2024

Cancer Medicine

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BackgroundCocaine is an illegal recreational drug used worldwide, yet little is known about whether cocaine inhalation (smoking/snorting) increases the risk of head and neck cancer (HNC).MethodsThe analyses were conducted by pooling data from three case–control studies with 1639 cases and 2506 controls from the International Head and Neck Cancer Epidemiology Consortium. Epidemiologic data, including cocaine use histories, were obtained in face‐to‐face interviews. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using hierarchical logistic regression models.ResultsControlling for cumulative tobacco and alcohol use, we observed a weak positive association between cocaine use and HNC (ORever vs. never = 1.35, 95% CI: 0.96, 1.90). In stratified analysis, while we did not detect associations among never tobacco or alcohol users due to the limited sample size, the association with cocaine use was observed among tobacco users and alcohol drinkers. ORs for ever and high cumulative use (>18 times) versus never use were 1.40 (95% CI: 0.98, 2.00) and 1.66 (95% CI: 1.03, 2.69) among tobacco users, and 1.34 (95% CI: 0.93, 1.92) and 1.59 (95% CI: 1.00, 2.51) among alcohol drinkers, respectively.ConclusionIn this pooled analysis, we observed a weak positive association between cocaine inhalation and HNC risk. Our findings provide preliminary evidence of the potential carcinogenic effect of cocaine on HNC. Because of study limitations, including limited number of cocaine users, confounding, and heterogeneity across studies, future investigations will require larger studies with more detailed information on cocaine use history.

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Polymorphisms ofMethionine SynthaseandMethionine Synthase Reductaseand Risk of Squamous Cell Carcinoma of the Head and Neck: a Case-Control Analysis

Cited by 57 publications

References 28 publications

5-Methyltetrahydrofolate-homocysteine methyltransferase gene polymorphism (MTR) and risk of head and neck cancer

5-Methyltetrahydrofolate-homocysteine methyltransferase gene polymorphism (MTR) and risk of head and neck cancer

Charge density effects on polyelectrolyte dynamic rheology

Cocaine use and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

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