Polymorphisms of Genes in the Lipid Metabolism Pathway and Risk of Biliary Tract Cancers and Stones: A Population-Based Case-Control Study in Shanghai, China

Andreotti, Gabriella; Chen, Jinbo; Gao, Yu Tang; Rashid, Asif; Chen, Bingshu E.; Rosenberg, Philip S.; Sakoda, Lori C.; Shen, Ming; Wang, Bing Sheng; Han, Tian; Zhang, Bai He; Yeager, Meredith; Welch, Robert; Chanock, Stephen J.; Fraumeni, Joseph F.; Hsing, Ann W.

doi:10.1158/1055-9965.epi-07-2704

Cited by 31 publications

(23 citation statements)

References 46 publications

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“…Details of the study have been described previously (Hsing et al, 2007a, b, c, d;Andreotti et al, 2008;Hsing et al, 2008). A total of 361 women with biliary tract cancer (269 gallbladder, 92 bile duct) between 35 and 74 years of age were included.…”

Section: Methodsmentioning

confidence: 99%

Reproductive factors and risks of biliary tract cancers and stones: a population-based study in Shanghai, China

et al. 2010

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BACKGROUND: Parity has been linked to gallbladder cancer and gallstones, but the effects of other reproductive factors are less clear. METHODS: We examined 361 incident biliary tract cancer cases, 647 biliary stone cases, and 586 healthy women in a population-based study in Shanghai. RESULTS: The effects of parity (odds ratios, OR X3 vs 1 child ¼ 2.0, 95% confidence interval (CI) 0.7 -5.1), younger age at first birth (OR per 1-year decrease ¼ 1.2, 95% CI 0.99 -1.6), and older age at menarche (OR per 1-year increase ¼ 1.4, 95% CI 1.1 -1.8) on gallbladder cancer risk were more pronounced among women with stones, but the interactions were not significant. CONCLUSION: Our results provide support for high parity, younger age at first birth, and late age at menarche in the development of gallbladder cancer, particularly among women with biliary stones.

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Section: Methodsmentioning

confidence: 99%

Reproductive factors and risks of biliary tract cancers and stones: a population-based study in Shanghai, China

et al. 2010

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“…Details of the methods of this population-based case-control study have been described previously (4,(8)(9)(10)(11). This study included 411 incident cases of biliary tract cancer (237 gallbladder, 127 bile duct and 47 ampulla of Vater), 895 biliary stone cases and 786 healthy controls randomly selected from the general population.…”

Section: Study Populationmentioning

confidence: 99%

Polymorphisms of estrogen receptors and risk of biliary tract cancers and gallstones: a population-based study in Shanghai, China

et al. 2010

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Biliary tract cancer encompasses tumors of the gallbladder, bile duct and ampulla of Vater. Gallbladder cancer is more common in women, whereas bile duct cancer is more common in men, suggesting that sex hormones may play a role in the etiology of these cancers. The intracellular action of estrogens is regulated by the estrogen receptor (ESR); thus, we examined the role of common genetic variants in ESR genes on the risk of biliary tract cancers and stones in a population-based case-control study in Shanghai, China (411 cancer cases, 895 stone cases and 786 controls). We genotyped six single-nucleotide polymorphisms (SNPs), four in ESR1 (rs2234693, rs3841686, rs2228480 and rs1801132) and two in ESR2 (rs1256049 and rs4986938). In all participants, the ESR1 rs1801132 (P325P) G allele was associated with excess risks of bile duct [odds ratio (OR) 5 1.7, 95% confidence interval (CI) 1.1-2.8] and ampulla of Vater cancers (OR 5 2.1, 95% CI 0.9-4.9) compared with the CC genotype. The association with bile duct cancer was apparent among men (OR 5 2.8, 95% CI 1.4-5.7) but not among women (P-heterogeneity 5 0.01). Also, the ESR2 rs4986938 (38 bp 3# of STP) GG genotype was associated with a higher risk of bile duct cancer (OR 5 3.3, 95% CI 1.3-8.7) compared with the AA genotype, although this estimate was based on a small number of subjects. None of the other SNPs examined was associated with biliary tract cancers or stones. False discovery rate-adjusted P-values were not significant (P > 0.1). No association was found for ESR1 haplotype based on four SNPs. These preliminary results suggest that variants in ESR genes could play a role in the etiology of biliary tract cancers, especially bile duct cancer in men.

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“…This is consistent with the GxE interaction we observed, and based on differential dietary cholesterol absorption or processing by an APOB variant in LD with this SNP . In addition, two SNPs further 5 ′ in the APOB gene but not in LD with the SNPs of interest here ( r 2 < 0.15) have been associated with an increased risk of biliary tract stones and cancer ( 42 ).…”

Section: Discussionmentioning

confidence: 71%

Novel gene-by-environment interactions: APOB and NPC1L1 variants affect the relationship between dietary and total plasma cholesterol

Kim

Burt

Ranchalis

et al. 2013

Journal of Lipid Research

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This article is available online at http://www.jlr.org Supplementary key words dietary cholesterol • total cholesterol • cardiovascular disease • Niemann-Pick C1-like 1 Cardiovascular disease (CVD), including coronary heart disease and carotid artery disease (CAAD), is the leading cause of death in developed countries, accounting for approximately one-third of all deaths in adults over age 35 ( 1 ). One of the key risk factors for CVD is hypercholesterolemia ( 2 ), with epidemiologic studies demonstrating a graded relationship between total plasma cholesterol and CVD risk ( 3 ). Levels of total cholesterol and other lipids and lipoproteins are both heritable and targets for pharmacologic and lifestyle interventions ( 4 ). One of the primary methods of lifestyle intervention to alter lipid levels is through dietary changes, such as decreasing total fat intake ( 5, 6 ).Genome-wide association studies (GWASs) have implicated numerous genetic loci for association with total cholesterol levels. A recent meta-analysis by Teslovich et al. ( 7 ) of over 100,000 individuals of European ancestry confi rmed numerous previous GWAS fi ndings and identifi ed novel variants and loci for prediction of total lipid phenotypes, including total cholesterol levels.While genetic evidence is accumulating for many of these loci, less is known about the specifi c mechanisms through which these genetic variants affect cholesterol levels. We hypothesized that one pathway through which these genetic variants could alter cholesterol homeostasis is through differential absorption or processing of dietary Abstract Cardiovascular disease (CVD) is the leading cause of death in developed countries. Plasma cholesterol level is a key risk factor in CVD pathogenesis. Genetic and dietary variation both infl uence plasma cholesterol; however, little is known about dietary interactions with genetic variants infl uencing the absorption and transport of dietary cholesterol . We sought to determine whether gut expressed variants predicting plasma cholesterol differentially affected the relationship between dietary and plasma cholesterol levels in 1,128 subjects (772/356 in the discovery/replication cohorts, respectively). Four single nucleotide polymorphisms (SNPs) within three genes ( APOB , CETP , and NPC1L1 ) were signifi cantly associated with plasma cholesterol in the discovery cohort. These were subsequently evaluated for geneby-environment (GxE) interactions with dietary cholesterol for the prediction of plasma cholesterol, with signifi cant fi ndings tested for replication. Novel GxE interactions were identifi ed and replicated for two variants: rs1042034, an APOB Ser4338Asn missense SNP and rs2072183 (in males only), a synonymous NPC1L1 SNP in linkage disequilibrium with SNPs 5 ′ of NPC1L1 . This study identifi es the presence of novel GxE and gender interactions implying that differential gut absorption is the basis for the variant associations with plasma cholesterol. These GxE interactions may account for part of the "missing heritability" no...

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Polymorphisms of Genes in the Lipid Metabolism Pathway and Risk of Biliary Tract Cancers and Stones: A Population-Based Case-Control Study in Shanghai, China

Cited by 31 publications

References 46 publications

Reproductive factors and risks of biliary tract cancers and stones: a population-based study in Shanghai, China

Reproductive factors and risks of biliary tract cancers and stones: a population-based study in Shanghai, China

Polymorphisms of estrogen receptors and risk of biliary tract cancers and gallstones: a population-based study in Shanghai, China

Novel gene-by-environment interactions: APOB and NPC1L1 variants affect the relationship between dietary and total plasma cholesterol

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