Polymorphisms of DNA Repair Genes and Risk of Glioma

Wang, Li E.; Bondy, Melissa L.; Shen, Hongbing; El‐Zein, Randa; Aldape, Kenneth; Cao, Yumei; Pudavalli, Vinay; Levin, Victor A.; Yung, W. K. Alfred; Wei, Qingyi

doi:10.1158/0008-5472.can-03-2181

Cited by 149 publications

(122 citation statements)

References 22 publications

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“…We have listed about 20 epidemiological studies reporting positive associations between DNA repair polymorphisms and cancer risk (Table 1 [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] ). Only a small proportion of studies were large (five studies were more than 500 pair cases and controls) and population based; however, some consistencies in results are apparent.…”

Section: Pbts Molecular Epidemiologic Studies With Focus On Dna Repairmentioning

confidence: 99%

Molecular Epidemiology of Primary Brain Tumors

Liu

Kyritsis

et al. 2009

Neurotherapeutics

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Summary:Although primary brain tumors (PBTs) are generally considered to be a multifactorial disorder, understanding the genetic basis and etiology of the disease is essential for PBT risk assessment. Understanding of the genetic susceptibility for PBT has come from studies of rare genetic syndromes, linkage analysis, family aggregation, early-onset pediatric cases, and mutagen sensitivity. There are currently no effective markers to assess biological dose of exposures and genetic heterogeneity. The priorities recently recommended by the Brain Tumor Epidemiology Consortium emphasized the need for expanding research in genetics and molecular epidemiology. In this article, we review the literature to identify molecular epidemiologic case-control studies of PBTs that were hypothesis-driven and focused on four hypothesized candidate pathways: DNA repair, cell cycle, metabolism, and inflammation. We summarize the results in terms of genetic associations of single nucleotide polymorphisms of these pathways. We also discuss future research directions based on available evidence and technologies, and conclude that high resolution whole genome approach with significantly large sample size could rapidly advance our understanding of the genetic etiology of PBTs. Literature searches were done on PubMed in March 2009 with the terms glioma, glioblastoma, brain tumor, association, and polymorphism, and we only reviewed English language publications.

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Section: Pbts Molecular Epidemiologic Studies With Focus On Dna Repairmentioning

confidence: 99%

Molecular Epidemiology of Primary Brain Tumors

Liu

Kyritsis

et al. 2009

Neurotherapeutics

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“…According to the inclusion and exclusion criteria, a total of nine publications with 3,752 Cases and 4,849 Controls were included in this meta-analysis (Wang et al, 2004;Kiuru et al, 2008;Liu et al, 2009;Zhou et al, 2009;Rajaraman et al, 2010;Custódio et al, 2012;Liu et al, 2012;Luo et al, 2013;Pan et al, 2013). Among the nine studies, four studies (Zhou et al, 2009;Liu et al, 2012;Luo et al, 2013;Pan et al, 2013) were performed in Asian populations and four (Wang et al, 2004;Kiuru et al, 2008;Liu et al, 2009;Rajaraman et al, 2010) were conducted in Caucasian populations.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Among the nine studies, four studies (Zhou et al, 2009;Liu et al, 2012;Luo et al, 2013;Pan et al, 2013) were performed in Asian populations and four (Wang et al, 2004;Kiuru et al, 2008;Liu et al, 2009;Rajaraman et al, 2010) were conducted in Caucasian populations. Five of the studies (Wang et al, 2004;Zhou et al, 2009;Rajaraman et al, 2010;Liu et al, 2012;Luo et al, 2013) were hospital-based and four (Kiuru et al, 2008;Liu et al, 2009;Custódio et al, 2012;Pan et al, 2013) were population-based. The genotype distributions in the controls were conformed to the HWE in all studies.…”

Section: Study Characteristicsmentioning

confidence: 99%

The XRCC3 Thr241Met Polymorphism Influences Glioma Risk - A Meta-analysis

Jiang

Quan²,

Zhang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Findings from previous published studies regarding the association of the XRCC3 Thr241Met polymorphism with glioma susceptibility have often been conflicting. Therefore, a meta-analysis including all available publications was carried out to make a more precise estimation of the potential relationship. Methods: By searching the electronic databases of Pubmed and Embase (up to April 1st, 2013), a total of nine case-control studies with 3,752 cases and 4,849 controls could be identified for inclusion in the current meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of the association. Results: This meta-analysis showed the XRCC3 Thr241Met polymorphism to be significantly associated with decreased glioma risk in the allelic model (Met allele vs. Thr allele: OR= 0.708, 95%CI= 0.631-0.795). Moreover, we also observed a statistically significant association between the XRCC3 Thr241Met polymorphism and reduced glioma risk in analyses stratified by ethnicity (Asian) and source of controls (hospital based) in the allelic model. Conclusions: Current evidence suggests that the XRCC3 Thr241Met polymorphism may be a risk factor for glioma development, especially in Asians.

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“…Currently, the etiology of glioma has not been completely understood. Previous studies have reported that a number of single nucleotide polymorphisms (SNPs) in DNA repair gene may modify glioma risk (Wang et al, 2004;Wrensch et al, 2005;Kiuru et al, 2008;Liu et al, 2009;Zhou et al, 2009;Rajaraman et al, 2010;Hu et al, 2011;Yosunkaya et al, 2010;Zhou et al, 2011). However, the clinical value of most glioma-associated molecular aberrations in terms of their significance as diagnostic, prognostic or predictive molecular markers has remained unclear (Batchelor et al, 2004;Ohgaki et al, 2004;Houillier et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

DNA Repair Gene ERCC1 and XPD Polymorphisms Predict Glioma Susceptibility and Prognosis

Chen

Yao²,

Zhao³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Aims: We conducted a case-control study in a Chinese population to clarify the association between polymorphisms in ERCC1 and XPD and susceptibility and survival of glioma. Methods: A total of 393 cases and 410 controls were selected from March 2007 to December 2011. Genotyping of ERCC1 and XPD was conducted by TaqMan assays using the ABI Prism 7911HT Sequence Detection System. All analyses were performed using the STATA statistical package. Results: Polymorphisms in ERCC1 118C/T, ERCC1 8092C/A and XPD Asp312Asn showed no statistically significant difference between glioma cases and controls. However, individuals with the XPD 751Gln/Gln genotype had an increased risk of developing glioma compared with those with the Lys/Lys genotype (adjusted OR=1.64, 95% CI: 1.06-2.89). The ERCC1 118T/T genotype was associated with significantly higher median survival than the ERCC1 C/C genotype (HR=0.67, 95%CI=0.35-0.96). In addition, individuals with XPD 751Gln/Gln had a lower median survival time than XPD Lys/Lys carriers (HR=0.54, 95%CI=0.37-0.93). Conclusion: In conclusion, we observed that the XPD 751Gln/Gln genotype is associated with glioma susceptibility, and ERCC1 118 T/T and XPD 751Gln/Gln genotypes confer a significantly better prognosis.

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Polymorphisms of DNA Repair Genes and Risk of Glioma

Cited by 149 publications

References 22 publications

Molecular Epidemiology of Primary Brain Tumors

Molecular Epidemiology of Primary Brain Tumors

The XRCC3 Thr241Met Polymorphism Influences Glioma Risk - A Meta-analysis

DNA Repair Gene ERCC1 and XPD Polymorphisms Predict Glioma Susceptibility and Prognosis

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