Polymorphisms in TP53 (rs1042522), p16 (rs11515 and rs3088440) and NQO1 (rs1800566) Genes in Thai Cervical Cancer Patients with HPV 16 Infection

Chansaenroj, Jira; Theamboonlers, Apiradee; Junyangdikul, Pairoj; Swangvaree, Sukumarn; Karalak, Anant; Chinchai, Teeraporn; Poovorawan, Yong

doi:10.7314/apjcp.2013.14.1.341

Cited by 21 publications

(18 citation statements)

References 39 publications

(43 reference statements)

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“…(Table IV). Accordingly, a significantly higher frequency of the CG genotype and G allele was detected in the samples in comparison with certain previous reports (20,33,35,36). Subgroup comparisons for the tumor behavior of prolactinoma have also shown that those with a high Ki67 index and with giant prolactinomas had a higher frequency of CG genotype as compared with the other groups (although not statistically significant) in the study and when compared with previous studies.…”

Section: Discussioncontrasting

confidence: 41%

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Association between p16(CDKN2A) C540G polymorphism and tumor behavior in prolactinoma: A single-center study

et al. 2014

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Abstract. Pituitary tumors usually originate as benign sporadic adenomas and develop into invasive and aggressive tumors such as prolactinomas, which are common functioning pituitary adenomas. The aim of the present study was to examine the association between the tumor behavior in prolactinomas and the p16(CDKN2A) gene polymorphism occurring at the 3'-untranslated region of exon 3 (C540G). A total of 104 patients with prolactinoma were included and assigned to two groups based on invasive vs. non-invasive tumor behavior. Ki67 indices were recorded according to histopathology results. Genotypic analysis of the p16(CDKN2A) C540G polymorphism was carried out using a modified polymerase chain reaction-restriction fragment length polymorphism assay. The corresponding frequencies for CC, CG and GG genotypes in non-invasive vs. invasive tumors were 61.5, 30.8, 7.7 and 64.1, 28.2, 7.7%, respectively (not significant). The observed CG genotype frequency was higher compared with previous studies. In addition, the patients with giant adenomas or a high Ki67 index had a higher frequency of the CG genotype as compared with the other subgroups, although the differences were not significant (46.2 and 42.9%, respectively). In conclusion, a higher frequency of the C540G CG genotype of the CDKN2A gene was found among patients with prolactinoma in comparison with previous studies. These frequencies were also higher in the subgroups with elevated Ki67 or giant adenomas. Further studies are required to improve the definition of the role of the CG genotype in the development and progression of tumors in prolactinomas.

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Section: Discussioncontrasting

confidence: 41%

“…Furthermore, no association between haplotypes of two different single-nucleotide polymorphisms and tumor progression has been found. Chansaenroj et al (35) have indicated that the frequencies of adjacent polymorphisms are not significantly increased in abnormal cervical lesions.…”

Section: Discussionmentioning

confidence: 99%

Association between p16(CDKN2A) C540G polymorphism and tumor behavior in prolactinoma: A single-center study

et al. 2014

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“…In China, there are nearly 150 000 new cervical cancer patients every year, and about 20 000 women die from the disease . Although high‐risk type HPV infection is considered to be the leading cause of cervical cancer occurrence, the exact mechanism of occurrence and development of cervical cancer has not been fully elucidated . Despite the improvement of therapeutic methods and diagnostic tools, the overall prognosis of patients has not been improved .…”

Section: Introductionmentioning

confidence: 99%

CD38 enhances the proliferation and inhibits the apoptosis of cervical cancer cells by affecting the mitochondria functions

Liao

Xiao

Chen

et al. 2017

Molecular Carcinogenesis

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Cervical cancer is one of the most common malignant tumors in women all over the world. The exact mechanism of occurrence and development of cervical cancer has not been fully elucidated. CD38 is a type II transmembrane glycoprotein, which was found to mediate diverse activities, including signal transduction, cell adhesion, and cyclic ADP-ribose synthesis. Here, we reported that CD38 promoted cell proliferation and inhibited cell apoptosis in cervical cancer cells by affecting the mitochondria functions. We established stable cervical cancer cell lines with CD38 over-expressed. CCK8 assay and colony formation assay indicated that CD38 promoted cervical cancer cell proliferation. Nude mouse tumorigenicity assay showed that CD38 significantly promotes tumor growth in vivo. CD38 also induced S phase accumulation in cell cycle analysis and suppressed cell apoptosis in cervical cancer cells. Meanwhile, flow cytometry analysis of mitochondria functions suggested that CD38 decreased intracellular Ca levels in cervical cancer cells and CD38 was involved in down-regulation of ROS levels and prevented mitochondrial apoptosis in cervical cancer cells. The percentage of cells with loss of mitochondrial membrane potential (Δψm) in CD38-overexpressed cervical cancer cells was less than control groups. Furthermore, we found an up-regulation of MDM2, cyclinA1, CDK4, cyclinD1, NF-kB P65, c-rel, and a downregulation of P53, P21, and P38 by Western blot analysis. These results indicated that CD38 enhanced the proliferation and inhibited the apoptosis of cervical cancer cells by affecting the mitochondria functions.

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“…Significant association of PP genotype of p.R72P polymorphism has been reported with increased risk for adenocarcinoma in Chinese nonsmoker females (Ren et al, 2013) and cervical cancer in Indians (Zhou et al, 2012). p.R72P polymorphism has also been reported to be associated with risk of cervical cancer development in Human papillomavirus (HPV) 16 infected women (Chansaenroj et al, 2013). In esophageal cancer, HPV may have a role only in the presence of altered promoter methylation of Aurora A and tobacco use (Mohiuddin et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Analysis of TP53 Polymorphisms in North Indian Sporadic Esophageal Cancer Patients

Kaur

Sambyal²,

Guleria³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Polymorphisms in TP53 (rs1042522), p16 (rs11515 and rs3088440) and NQO1 (rs1800566) Genes in Thai Cervical Cancer Patients with HPV 16 Infection

Cited by 21 publications

References 39 publications

Association between p16(CDKN2A) C540G polymorphism and tumor behavior in prolactinoma: A single-center study

Association between p16(CDKN2A) C540G polymorphism and tumor behavior in prolactinoma: A single-center study

CD38 enhances the proliferation and inhibits the apoptosis of cervical cancer cells by affecting the mitochondria functions

Analysis of TP53 Polymorphisms in North Indian Sporadic Esophageal Cancer Patients

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