Polymorphisms in the type I deiodinase gene and frontal function in recurrent depressive disorder

Gałecka, Elżbieta; Talarowska, Monika; Orzechowska, Agata; Górski, Paweł; Szemraj, Janusz

doi:10.1016/j.advms.2015.12.008

Cited by 5 publications

(2 citation statements)

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“…Their analysis of cognitive functioning was restricted, however, to the Ruff Figural Fluency test, a test of non-verbal fluency, and did not reveal an effect of the DIO2 polymorphism. Galecka et al [67] investigated polymorphisms in the DIO1 rather than DIO2 gene in a sample of patients with recurrent depressive disorder. Cognitive testing comprised the Trail Making Test, the Stroop Test and a Verbal Fluency Test.…”

Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphisms in Thyroid Hormone Transporter Genes MCT8, MCT10 and Deiodinase DIO2 Contribute to Inter-Individual Variance of Executive Functions and Personality Traits

Uter

Krämer

Schöls

et al. 2019

Exp Clin Endocrinol Diabetes

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Thyroid hormones are modulators of cognitive functions, and changes in hormone levels affect intelligence, memory, attention and executive function. Single nucleotide polymorphisms (SNPs) of transporter proteins MCT8, MCT10 and deiodinase 2 (DIO2) influence thyroid metabolism and could therefore contribute to inter-individual variance of cognitive functions. This study investigates the influence of these SNPs using an extensive neuropsychological test battery. 656 healthy participants aged 18–39 years were genotyped for four SNPs: MCT8 (rs5937843 and rs6647476), MCT10 (rs14399) and DIO2 (rs225014) and underwent eleven different neuropsychological tests as well as four personality questionnaires. Test results were compared between homo- and heterozygous carriers and for the X-linked MCT8 additionally between men and women. Personality questionnaires revealed that Risk Seeking was reduced in homozygous T carriers and highest in homozygous C carriers of the DIO2 SNP and that both polymorphisms of MCT8 had an additive effect on Physical Aggression in men. Neuropsychological testing indicated that MCT10 affects nonverbal reasoning abilities, DIO2 influences working memory and verbal fluency and MCT8 influences attention, alertness and planning. This pilot study suggests an influence of polymorphisms in thyroid hormone transporter genes and deiodinase on cognitive domains and personality traits.

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Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphisms in Thyroid Hormone Transporter Genes MCT8, MCT10 and Deiodinase DIO2 Contribute to Inter-Individual Variance of Executive Functions and Personality Traits

Uter

Krämer

Schöls

et al. 2019

Exp Clin Endocrinol Diabetes

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“…In contrast, the Thr92Ala polymorphism did not demonstrate a statistically significant difference, even though it was more prevalent in the Thr/Thr genotype in patients with depression ( 20 ). Conversely, a study in Poland indicated that the Ala–Ala genotype of the Thr92Ala polymorphism was more common in healthy individuals compared to those with recurrent depression (7.2% vs. 0.6%, p = 0.03, respectively), suggesting its potential as a marker for reduced risk of recurrent depressive disorder ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

The Thr92Ala polymorphism in the type 2 deiodinase gene is linked to depression in patients with COVID-19 after hospital discharge

Beltrão,

Carvalhal

et al. 2024

Front. Endocrinol.

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BackgroundThe Thr92Ala-DIO2 polymorphism has been associated with clinical outcomes in hospitalized patients with COVID-19 and neuropsychiatric diseases. This study examines the impact of the Thr92Ala-DIO2 polymorphism on neuropsychological symptoms, particularly depressive symptoms, in patients who have had moderate to severe SARS-CoV-2 infection and were later discharged.MethodsOur prospective cohort study, conducted from June to August 2020, collected data from 273 patients hospitalized with COVID-19. This included thyroid function tests, inflammatory markers, hematologic indices, and genotyping of the Thr92Ala-DIO2 polymorphism. Post-discharge, we followed up with 68 patients over 30 to 45 days, dividing them into depressive (29 patients) and non-depressive (39 patients) groups based on their Beck Depression Inventory scores.ResultsWe categorized 68 patients into three groups based on their genotypes: Thr/Thr (22 patients), Thr/Ala (41 patients), and Ala/Ala (5 patients). Depressive symptoms were less frequent in the Thr/Ala group (29.3%) compared to the Thr/Thr (59.1%) and Ala/Ala (60%) groups (p = 0.048). The Thr/Ala heterozygous genotype correlated with a lower risk of post-COVID-19 depression, as shown by univariate and multivariate logistic regression analyses. These analyses, adjusted for various factors, indicated a 70% to 81% reduction in risk.ConclusionOur findings appear to be the first to show that heterozygosity for Thr92Ala-DIO2 in patients with COVID-19 may protect against post-COVID-19 depression symptoms up to 2 months after the illness.

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New insights on thyroid hormone and the brain

Bernal

2018

Current Opinion in Endocrine and Metabolic Research

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Polymorphisms in the type I deiodinase gene and frontal function in recurrent depressive disorder

Cited by 5 publications

References 31 publications

Single Nucleotide Polymorphisms in Thyroid Hormone Transporter Genes MCT8, MCT10 and Deiodinase DIO2 Contribute to Inter-Individual Variance of Executive Functions and Personality Traits

Single Nucleotide Polymorphisms in Thyroid Hormone Transporter Genes MCT8, MCT10 and Deiodinase DIO2 Contribute to Inter-Individual Variance of Executive Functions and Personality Traits

The Thr92Ala polymorphism in the type 2 deiodinase gene is linked to depression in patients with COVID-19 after hospital discharge

New insights on thyroid hormone and the brain

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