Polymorphisms in the TNF-α and IL-10 gene promoters and risk of psoriasis and correlation with disease severity

Karam, Rehab A.; Zidan, Haidy E.; Khater, Mohamed Hamed

doi:10.1016/j.cyto.2014.01.008

Cited by 27 publications

(28 citation statements)

References 39 publications

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“…Also, that these risk associations were still significant in PGPP, but not AGPP patients, suggests that the −238A variant may be mainly responsible for explaining the susceptibility to early‐onset GPP. Additionally, although there are studies suggesting associations between TNF −308A/G and −857C/T polymorphisms and the psoriasis, no significant results were observed in our study of PGPP and AGPP. This may be attributed to the different types of psoriasis investigated, small sample size or differences in race.…”

Section: Discussioncontrasting

confidence: 99%

“…Recent studies have explored the association between single nucleotide polymorphisms (SNP) in the promoter region of TNF , in particular −238G/A (rs361525) and −308G/A (rs1800629), and the pathogenesis of psoriasis. Nevertheless, the conclusion remained inconsistent among diverse races . Most current studies have focused on psoriasis vulgaris (PV) rather than GPP.…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, the conclusion remained inconsistent among diverse races. [4][5][6] Most current studies have focused on psoriasis vulgaris (PV) rather than GPP. Although Nishibu et al 4 implied that the TNF À308A polymorphism may be associated with GPP, only two patients were enrolled in their study.…”

Section: Introductionmentioning

confidence: 99%

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Tumor necrosis factor –238A is associated with pediatric‐onset generalized pustular psoriasis in Han patients in Eastern China

Zhao

Sun

et al. 2019

The Journal of Dermatology

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The correlation between polymorphisms at the tumor necrosis factor (TNF) gene and generalized pustular psoriasis (GPP) has rarely been reported. The goal of this study is to investigate whether TNF polymorphisms (−238 A/G, −308 A/G, −857C/T) are associated with susceptibility to GPP in a Han population from Eastern China and to perform subgroup analysis to explore the influence of age onset. Polymorphisms were assessed by polymerase chain reaction amplification and resequencing in 91 GPP patients and 102 healthy controls. The frequencies of the TNF −238A allele and GA+AA genotypes were significantly higher in GPP patients than in those of healthy controls. The subgroup analysis revealed that these significant associations were still present between −238A variants and pediatric‐onset GPP patients who developed GPP at less than 18 years old (PGPP), but not for patients with adult‐onset GPP who developed GPP at 18 years old or more. There were no significant differences in genotype or allele frequencies of TNF −308 A/G and −857C/T polymorphisms between GPP and controls. In conclusion, individuals carrying TNF −238A may be more susceptible to PGPP.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Tumor necrosis factor –238A is associated with pediatric‐onset generalized pustular psoriasis in Han patients in Eastern China

Zhao

Sun

et al. 2019

The Journal of Dermatology

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“…Jia et al defined an increased risk of psoriasis for the 238G/A polymorphism and a reduced risk of psoriasis for the –308G/A polymorphism. On the other hand, TNF-α 238G/A and TNF-α 308 G/A polymorphisms are reported to be relevant to diabetes [18], CAD [19], and hypertension [5]. None of the studies have evaluated the link between TNF-α G238A and G308A polymorphisms and hypertension, CAD or diabetes among psoriasis patients.…”

Section: Discussionmentioning

confidence: 99%

Is there any increased risk of hypertension, diabetes and cardiac diseases in psoriatic patients with TNF-α G238A and G308A polymorphism?

Işık

Hız

Kılıç

et al. 2016

pdia

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IntroductionPsoriasis is regarded as a complex autoimmune disease with strong genetic background. Psoriatic patients suffer from many comorbidities including hypertension, diabetes and cardiovascular diseases. Cytokines such as tumor necrosis factor α (TNF-α) may be a key player that triggers psoriasis and diabetes, hypertension and cardiac disease at the same time.AimTo evaluate genetic variations in the TNF-α region and its association with psoriasis and related comorbidities.Material and methodsThe study covered 129 psoriasis patients with three main subgroups with coronary artery disease (n = 41), hypertension (n = 35), and diabetes (n = 21). DNA samples were genotyped for TNF-α G308A and G238A polymorphisms by real-time polymerase chain reaction melting-curve analysis and results were compared statistically.ResultsPsoriatic patients with both TNF-α-298 and TNF-α-308 polymorphisms showed no statistically significant increase in the risk of hypertension (OR = 0.425, χ² = 1.76, p = 0.18 and OR = 1.87, χ² = 1.33, p = 0.25), coronary artery disease (OR = 1.97, χ² = 1.91, p = 0.17 and OR = 2.63, χ² = 1.35, p = 0.25), or diabetes (OR = 1.35, χ² = 0.24, p = 0.62 and OR = 1.53, χ² = 0.24, p = 0.62).ConclusionsThe current preliminary results suggested that there was no correlation between TNF-α promoter polymorphism and diabetes, hypertension and cardiac disease among psoriatic patients in the Turkish population.

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“…Meta-analysis with fixed-effects showed a significant association between PS and IL4 rs2243250 For TNFA, several meta-analyses have been published so far; therefore, we have chosen one that provided all necessary tabulated data (Jia et al, 2013) and updated it with the results of our study as well as with the results of tree other recent studies (Karam et al, 2014;Cardili et al, 2015;Popa et al, 2011). For PS, the data were stratified by Caucasian and Asian cohorts, while for PsA, only Caucasian cohorts were included because only one small Asian study data were provided.…”

Section: Resultsmentioning

confidence: 99%

Analysis of association between cytokine gene polymorphisms and psoriatic disease in Russians of East Siberia

et al. 2019

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Polymorphisms in the TNF-α and IL-10 gene promoters and risk of psoriasis and correlation with disease severity

Cited by 27 publications

References 39 publications

Tumor necrosis factor –238A is associated with pediatric‐onset generalized pustular psoriasis in Han patients in Eastern China

Tumor necrosis factor –238A is associated with pediatric‐onset generalized pustular psoriasis in Han patients in Eastern China

Is there any increased risk of hypertension, diabetes and cardiac diseases in psoriatic patients with TNF-α G238A and G308A polymorphism?

Analysis of association between cytokine gene polymorphisms and psoriatic disease in Russians of East Siberia

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