Polymorphisms in the promoter regions of the matrix metalloproteinases-1, -3, -7, and -9 and the risk of epithelial ovarian cancer in China

Li, Yan; Jin, Xia; Kang, Shan; Wang, Ying; Du, Huarui; Zhang, Jianhui; Guo, Wei; Wang, Na; Fang, Shumei

doi:10.1016/j.ygyno.2005.09.058

Cited by 74 publications

(57 citation statements)

References 32 publications

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“…However, few studies other than the first report by Tanimoto et al (32) have investigated the role of MMP-7 in EOC. The significant difference of MMP-7 genotype and allelotype distribution in ovarian cancer patients from that in healthy controls found by Li et al (84) suggests a possible association between the MMP-7 A/G with susceptibility to EOC. We have previously shown that MMP-7 is overexpressed in the invasive front of EOC and promotes invasion.…”

Section: Discussionmentioning

confidence: 77%

Inhibition of Matrilysin Expression by Antisense or RNA Interference Decreases Lysophosphatidic Acid–Induced Epithelial Ovarian Cancer Invasion

Wang

Smicun

Calluzzo

et al. 2006

Molecular Cancer Research

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Our previous reports show that matrilysin [matrix metalloproteinase (MMP)-7] is overexpressed in epithelial ovarian cancer (EOC) and recombinant MMP-7 promotes EOC invasion in vitro. In the present study, we further evaluated the correlation of MMP-7 expression to EOC invasiveness and examined its role in lysophosphatidic acid (LPA)-induced invasion. By sense and antisense gene transfection in vitro, we show that overexpression of MMP-7 in all MMP-7 stably transfected DOV13 clones significantly enhanced their invasiveness, although MMP-7 antisense transfection caused a 91% decrease of MMP-7 expression (P < 0.01) and 87% decrease of invasion (P < 0.05) in geneticin (G418)-selected DOV13 clone P47-M7As-3 compared with vector-transfected control.As assessed by MMP-7 ELISA, LPA treatment at 10 to 80 Mmol/L significantly stimulated the secretion of total MMP-7 in DOV13 conditioned medium (P < 0.01). In addition, LPA apparently induced the activation of MMP-7 in DOV13 cells as detected by gelatin zymography. In the antisense MMP-7-transfected DOV13 clone (P47-M7As-3), LPA-increased invasion was significantly decreased compared with vector control. Moreover, knocking down of MMP-7 by small interfering RNA also suppressed LPA-induced invasion in two EOC cell lines (DOV13 and R182). Altogether, our results show that MMP-7 expression is correlated with EOC invasiveness and LPA-induced MMP-7 secretion/ activation may represent a new mechanism that facilitates ovarian cancer invasion besides the well-known induction of MT1-MMP-mediated proMMP-2 activation by LPA. (Mol Cancer Res 2006;4(11):831 -41)

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Section: Discussionmentioning

confidence: 77%

Inhibition of Matrilysin Expression by Antisense or RNA Interference Decreases Lysophosphatidic Acid–Induced Epithelial Ovarian Cancer Invasion

Wang

Smicun

Calluzzo

et al. 2006

Molecular Cancer Research

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“…The G allele of the MMP7 -181 A/G SNP creates a putative binding site for a heat shock transcription factor, thereby increasing MMP7 gene promoter activity and transcription compared to the -181 A allele [34]. The G allele has been reported as a potential risk factor for several gynecological disorders, including endometriosis and adenomyosis [32], as well as endometrial [27], ovarian [26], and cervical cancers [28]. Moreover, the presence of the G allele has been associated with increased levels of malondialdehyde, a marker of lipid peroxidation, in severe preeclampsia [33].…”

Section: Discussionmentioning

confidence: 99%

“…Conditions were taken from previous studies and were slightly modified [26,29] (Table 1). Polymerase chain reaction was carried in thermal cyclers (Mastercycle Personal, Eppendorf, Hamburg, Germany and 2720 Thermal Cycler, Applied Biosystems, Carlsbad, CA, USA).…”

Section: Molecular Genetic Methodsmentioning

confidence: 99%

“…In the present study, we extended this analysis to MMP7 and 12 genes, both of which exert important functions in pregnancy, including implantation and remodeling of spiral arteries. Additionally, polymorphisms in these genes have been investigated in different disorders, including gynecological [26][27][28] and non-gynecological cancers [29][30][31], as well as reproductive disorders [32,33] and various systemic disorders [34][35][36]. Our aim was to evaluate the potential association between IRSA in Slovenian reproductive couples and MMP7 -181 A/G and MMP12 -82 A/G functional SNPs, which are located in gene promoter regions.…”

Section: Introductionmentioning

confidence: 99%

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Functional single nucleotide polymorphisms of matrix metalloproteinase 7 and 12 genes in idiopathic recurrent spontaneous abortion

Barišić

Pereza

Hodžić

et al. 2016

J Assist Reprod Genet

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Purpose The aim of this study was to investigate the potential association of matrix metalloproteinase 7 (MMP7) -181 A/G and MMP12 -82 A/G functional single nucleotide polymorphisms (SNP) with idiopathic recurrent spontaneous abortion (IRSA) in Slovenian reproductive couples. Methods A case-control study was conducted on 149 couples with 3 or more consecutive idiopathic spontaneous pregnancy loses and 149 women and men with at least 2 live births and no history of pregnancy complications. Genotyping of MMP7 -181 A/G and MMP12 -82 A/G SNPs was performed using polymerase chain reaction and restriction fragment length polymorphism methods. Results There were no statistically significant differences in the distribution of MMP7 -181 A/G and MMP12 -82 A/G genotype, allele, or haplotype frequencies between IRSA patients and controls, as well as patients' primary and secondary IRSA. We also found no association of MMP7 -181 A/G and MMP12 -82 A/G genotypes, alleles, and haplotypes with IRSA. Conclusions We found no evidence to support the association between IRSA and MMP7 -181 A/G and MMP12 -82 A/G SNPs in Slovenian reproductive couples.

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“…The matrix metalloproteinase (MMPs) family comprise of more than 20 enzymes that are capable of degrading extracellular matrix proteins (Li et al, 2006;Singh et al, 2008;Wu et al, 2011). MMPs not only play important roles in physiological ECM remodelling, such as wound repair, tissue regeneration and embryo development, but are also associated with pathological conditions, such as arthritis, atherosclerosis and autoimmune blistering disorders of the skin.…”

Section: Introductionmentioning

confidence: 99%

Current Evidence on Associations Between the MMP-7 (-181A>G) Polymorphism and Digestive System Cancer Risk

Pan

Zhong-de²,

Wen³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Polymorphisms in the promoter regions of the matrix metalloproteinases-1, -3, -7, and -9 and the risk of epithelial ovarian cancer in China

Cited by 74 publications

References 32 publications

Inhibition of Matrilysin Expression by Antisense or RNA Interference Decreases Lysophosphatidic Acid–Induced Epithelial Ovarian Cancer Invasion

Inhibition of Matrilysin Expression by Antisense or RNA Interference Decreases Lysophosphatidic Acid–Induced Epithelial Ovarian Cancer Invasion

Functional single nucleotide polymorphisms of matrix metalloproteinase 7 and 12 genes in idiopathic recurrent spontaneous abortion

Current Evidence on Associations Between the MMP-7 (-181A>G) Polymorphism and Digestive System Cancer Risk

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