Polymorphisms in the<i>SP110</i>and<i>TNF-α</i>Gene and Susceptibility to Pulmonary and Spinal Tuberculosis among Southern Chinese Population

Zhou, Ying; Tan, Chee Eng; Zhang, Mo; Gao, Qile; He, Dan; Li, Jiong; Huang, Rongfu; Li, Yanbing; Guo, Chaofeng; Guo, Qiang; Wang, Long-jie; Yang, Guanteng; Zhang, Hongqi

doi:10.1155/2017/4590235

Cited by 13 publications

(11 citation statements)

References 29 publications

(41 reference statements)

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“…Thus, loss of Ipr1/Sp110 may account for the Sst1 S phenotype, though this remains to be confirmed by the generation of B6.Ipr1 −/− mice. Polymorphisms in human SP110 are associated with TB disease in some but not all cohorts [61][62][63][64][65][66][67][68] . Ipr1/Sp110 is a member of the Sp100 family of transcriptional regulators that also includes Sp100, Sp140, and Aire.…”

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confidence: 99%

Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra

et al. 2019

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The bacterium Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB) and is responsible for more human mortality than any other single pathogen 1. Progression to active disease occurs in only a fraction of infected individuals and is predicted by an elevated type I interferon (IFN) response 2-7. Whether or how IFNs mediate susceptibility to Mtb has been difficult to study due to a lack of suitable mouse models 6-11. Here we examined B6.Sst1 S congenic mice that carry the "sensitive" allele of the Sst1 locus that confers susceptibility to Mtb 12-14. We found that enhanced production of type I IFNs was responsible for the susceptibility of B6.

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confidence: 99%

Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra

et al. 2019

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“…Meanwhile, the study of Zhou et al (2017) provides further evidence supporting the host genetic variability in TB susceptibility, especially in different types of TB infection which is the TNF-α -238 A allele indicates a protective effect against STB, but not against PTB, whereas the SP110 SNPs (rs722555 and rs1135791) and TNF-α -308G>A (rs1800629) showed no association with susceptibility to PTB and STB in southern China. In the same way, there was a susceptible genetic factor and the possible outcome of PTB infection.…”

Section: Perceived Susceptibility and Threatsmentioning

confidence: 95%

Relationship of Perceived Susceptibility and Threats to Prevention Practices of Pulmonary Tuberculosis Among Indonesians as Moderated by Cultural Beliefs

Nababan

Jael

2019

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Introduction: Pulmonary Tuberculosis (PTB) appears to lead in the worldwide unending battle of health problems. This study sought to determine the relationship of perceived susceptibility and threats to Pulmonary Tuberculosis (PTB) prevention practices as moderated by cultural beliefs. Methods: Descriptive evaluative and correlational research designs were utilized. The study employed 393 respondents (20-55 years old) from five provinces in Indonesia with the highest incidence of PTB, selected through the multi-stage and purposive sampling technique. The data analyzed through the SPSS program, utilized statistical methods: Mean and Standard Deviation, Correlation Analysis, and Structural Equation Modelling (SEM) using AMOS. Results: The respondents had high perceived susceptibility and threats (mean = .755, SD = .421), and practiced the PTB prevention sometimes (mean = 3.347 and SD = .826). This implies that Indonesian adults understand that certain conditions and practices would lead them or put them at risk to be infected with PTB. Perceived susceptibility and threats have a positive weak significant correlation (r = .320̽ ̽, ρ = .000) with PTB prevention practices. The higher the perceived susceptibility and threats, the better is the PTB prevention practices. The perceived susceptibility and threats has influenced over their prevention practices. Cultural beliefs have a moderating role (estimate value of - .053, ρ = .000) in the relationship of perceived susceptibility and threats to PTB prevention practices. The stronger the respondents hold on to their cultural beliefs, the weaker is the impact of perceived susceptibility and threats. Discussion: Further study from other provinces that excluded in this study and on another specific culture related to PTB prevention practices with a comparison of different population groups (urban and rural), and with a bigger sample size. Also, may employ a qualitative research method to explore in depth understanding of the phenomenon.

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“…In recent years, drug-resistant tuberculosis, particularly multidrug-resistant tuberculosis, has emerged globally ( 5 ). Additionally, an increase in longer chemotherapy cycles and drug side effects have presented major challenges to effectively control osteoarticular tuberculosis ( 6 , 7 ). Therefore, the pathogenic mechanism of osteoarticular tuberculosis must be determined to develop new and effective prevention and treatment strategies.…”

Section: Introductionmentioning

confidence: 99%

Mycobacterium tuberculosis infection increases the number of osteoclasts and inhibits osteoclast apoptosis by regulating TNF‑α‑mediated osteoclast autophagy

et al. 2020

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Osteoarticular tuberculosis, a chronic inflammatory disease characterized by Mycobacterium tuberculosis ( M.tb ) infection, has become a serious problem in China. The present study was conducted to determine the mechanism of action of tumor necrosis factor (TNF)-α in the pathogenesis of osteoarticular tuberculosis. The number of osteoclasts in osteoarticular tuberculosis tissue samples was detected by tartrate-resistant acid phosphatase staining. Autophagy and apoptosis of osteoclasts were detected by western blotting, reverse transcription-quantitative PCR, transmission electron microscopy and TUNEL staining. The results showed that autophagy and the number of osteoclasts increased in the lesions of patients with osteoarticular tuberculosis compared with osteoarthritis samples. Moreover, activation of osteoclast autophagy inhibited the apoptosis of osteoclasts infected with M.tb , and increased the expression level of TNF-α. The results showed that TNF-α enhanced the autophagic activity of M.tb -infected osteoclasts and inhibited cell apoptosis. These findings indicated that M.tb infection induced osteoclast production and inhibited osteoclast apoptosis by regulating TNF-α-mediated osteoclast autophagy, revealing a new mechanism for TNF-α in the pathogenesis of osteoarticular tuberculosis.

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Polymorphisms in theSP110andTNF-αGene and Susceptibility to Pulmonary and Spinal Tuberculosis among Southern Chinese Population

Cited by 13 publications

References 29 publications

Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra

Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra

Relationship of Perceived Susceptibility and Threats to Prevention Practices of Pulmonary Tuberculosis Among Indonesians as Moderated by Cultural Beliefs

Mycobacterium tuberculosis infection increases the number of osteoclasts and inhibits osteoclast apoptosis by regulating TNF‑α‑mediated osteoclast autophagy

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