Polymorphisms in the human ALOX12 and ALOX15 genes are associated with peak bone mineral density in Chinese nuclear families

Abstract

Our results suggest that the genetic polymorphisms in both human ALOX12 and ALOX15 may contribute to variations in the peak BMD of Chinese women.

Polymorphisms in inflammation associated genes ALOX15 and IL-6 are associated with bone properties in young women and fracture in elderly

“…The rationale for SNP selection at the time when genotyping was performed is outlined below. SNPs for ALOX12 were selected from the literature as having been previously investigated for BMD [16,18,20]. SNP rs312466…”

“…For ALOX15, with the exception of rs8074545 upstream of the coding region (which is intergenic and therefore has potential functionality) all selected SNPs were tagging SNPs previously investigated for BMD (rs748694; rs9894225; rs916055; rs2619112) [20]. The IL--6 tagging SNP rs10242595, located downstream of the coding region was selected for its previous association with decreased fat mass [40] while PPARγ rs1801282 (Pro12Ala) is the most extensively examined in a variety of diseases including osteoporosis [31].…”

ALOX12 gene polymorphisms and serum selenium status in elderly osteoporotic patients

“…Using extensive literature searches, among all known polymorphisms of ALOX12, 2 SNPs (rs9897850 and rs2292350) were selected on the basis of other researchers' findings. 1,4,5,7 Both SNPs were listed in the National Center for Biotechnology Information (NCBI) SNP database and happened to be very common (minor allele frequencies >0.35).…”

“…Studies show that up to 80% of BMD variation is attributable to genetic factors. [4][5][6][7] A link between hip, spine and wrist BMD and the arachidonate 12-lipoxygenase (ALOX12) gene has been reported, and some researchers have suggested that ALOX12 is a susceptible gene for BMD variation. ALOX12 belongs to the arachidonate lipoxygenase enzyme super-family, which catalyzes the insertion of molecular oxygen into polyunsaturated fatty acids, such as arachidonic acid.…”

“…13,14 Accordingly, several single nucleotide polymorphisms (SNPs) in ALOX12 have been suggested as being associated with BMD variations in humans, but the results are controversial. 1,4,5,7,15 Selenium (Se) is an essential trace element that incorporates into selenoproteins as selenocysteine -the 21 st amino acid. Various members of the glutathione peroxidase (GPx) family (including phospholipid hydroperoxide glutathione peroxidase -PHGPx) are well-known selenoproteins with antioxidant capacity that play an important role in the scavenging of lipid peroxide products.…”