Polymorphisms in the hepatitis C virus core and its association with development of hepatocellular carcinoma

Sedeño-Monge, Virginia; Vallejo-Ruíz, Verónica; Sosa-Jurado, Francisca; Santos‐López, Gerardo

doi:10.1007/s12038-017-9695-4

Cited by 3 publications

(3 citation statements)

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“…For example, it has been shown that HCV genotype 3 is associated with higher risk of developing HCC (3–6) and with lower rates of treatment success for direct-acting antivirals (7,8). Furthermore, amino acid variation in the NS5A protein is associated with viral load (9,10) and amino acid variation in the core protein is associated with the development of HCC (11).…”

Section: Introductionmentioning

confidence: 99%

Global spread and evolutionary history of HCV subtype 3a

S-K.

Maio

Pedergnana

et al. 2021

Preprint

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Studies have shown that HCV subtype 3a had likely been circulating in South Asia before its global spread. However, the time and route of this dissemination remain unclear. For the first time, we generated host and virus genome-wide data for more than 500 patients infected with HCV subtype 3a from the UK, North America, Australia and New Zealand. We used the host genomic data to infer the ancestry of the patients and used this information to investigate the epidemic history of HCV subtype 3a. We observed that viruses from hosts of South Asian ancestry clustered together near the root of the tree, irrespective of the sampling country and that they were more diverse than viruses from other host ancestries. We also inferred that three independent transmission events resulted in the spread of the virus from South Asia to the UK, North America and the Australian continent. This initial spread happened during or soon after the end of the second world war. This was followed by an exponential growth in the effective population size of HCV subtype 3a worldwide and many independent transmissions between the UK, North America and Australian continent. Using both host and virus genomic information can be highly informative in studying the virus epidemic history especially in the context of chronic infections.

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Section: Introductionmentioning

confidence: 99%

Global spread and evolutionary history of HCV subtype 3a

S-K.

Maio

Pedergnana

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…For instance, it has been shown that HCV genotype 3 is associated with a higher risk of developing HCC ( Nkontchou et al, 2011 ; Kanwal et al, 2014 ; El-Serag et al, 2016 ; Lee et al, 2019 ) and with higher rates of direct-acting antiviral treatment failures ( Jacobson et al, 2013 ; Lawitz et al, 2013 ). Furthermore, amino acid variation in the NS5A protein is associated with viral load ( Ansari et al, 2017 , 2019 ), and amino acid variation in the core protein is associated with the development of HCC ( Sedeño-Monge et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Using host genetics to infer the global spread and evolutionary history of HCV subtype 3a

et al. 2021

View full text Add to dashboard Cite

Studies have shown that HCV subtype 3a is likely to have been circulating in South Asia before its global spread. However, the time and route of this dissemination remain unclear. For the first time, we generated host and virus genome-wide data for more than 500 patients infected with HCV subtype 3a from the UK, North America, Australia and New Zealand. We used the host genomic data to infer the ancestry of the patients and used this information to investigate the epidemic history of HCV subtype 3a. We observed that viruses from hosts of South Asian ancestry clustered together near the root of the tree, irrespective of the sampling country and that they were more diverse than viruses from other host ancestries. We hypothesized that South Asian hosts are more likely to have been infected in South Asia and used the inferred host ancestries to distinguish between location where the infection was acquired and where the sample was taken. Next, we inferred that three independent transmission events resulted in the spread of the virus from South Asia to the UK, North America and Oceania. This initial spread happened during or soon after the end of World War II. This was subsequently followed by many independent transmissions between the UK, North America and Oceania. Using both host and virus genomic information can be highly informative in studying the virus epidemic history, especially in the context of chronic infections where migration histories need to be accounted for.

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“…IL7RA rs987106 showed a weaker association with the progression of liver disease while IL7RA rs3194051 did not [20]. Therefore, although current DAAs have been a transcendental change in treatment of HCV liver diseases, modifying substantially their natural history; genetic polymorphisms can be a very important tool in the management of HCV liver disease [21] and will be probably a key factor in the evolution of patients once the sustained viral response with antiviral treatment has been achieved.…”

mentioning

confidence: 99%