Polymorphisms in the Estrogen Receptor Alpha Gene and Mammographic Density Result Study in Brazilian Women

Abstract

This article presents the results of the case-control study in the city of São Paulo, that examined the association of the polymorphisms in the genes ERα-PvuII and ERα-XbaI with the risk of high mammographic density after menopause. The associations of these polymorphisms with other risk factors for breast cancer were also evaluated. MethodsCase-control study that included 308 women with HMD(for more than 50% density) and 155 controls(to 50% density or less) evaluated by computerized objective method [25], aged 45-65, without menstruation or hormone therapy for at least 1 year, without previous BC and ovarian cancer. Initially, the patients were selected in a subjective way by the standard ACR-BIRADS ® , by a unique reader (the head