Polymorphisms in the caspase-8 gene and the risk of lung cancer

Son, Ji Woong; Kang, Hyo-Kyung; Chae, Myung Hwa; Choi, Jin Eun; Park, Jung Min; Lee, Won Kee; Kim, Chang Ho; Kim, Dong Sun; Kam, Sang-Kyu; Kang, Young Mo; Park, Jae Yong

doi:10.1016/j.cancergencyto.2006.04.001

Cited by 59 publications

(46 citation statements)

References 33 publications

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“…Single nucleotide polymorphisms (SNPs) are the most common form of human genetic variation and may contribute to individual susceptibility to cancer (Son et al, 2006). In recent years, many studies have been conducted to investigate the associations between CASP-3 and CASP-7 genes and cancer susceptibility.…”

Section: Introductionmentioning

confidence: 99%

HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk

Yan¹,

Li²,

Zhu³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Genetic variations in the caspase genes CASP-3 and CASP-7 are known to be involved in apoptosis, cytokine maturation, cell growth and differentiation. Polymorphisms of CASP-3 and CASP-7 genes have been increasingly recognized as important regulators in the development of cancer. However, whether there is a specific association is still controversial. Therefore, we made a Human Genome Epidemiology review and meta-analysis to explore the association between polymorphisms of CASP-3 and CASP-7 genes and cancer risk. Based on the inclusion criteria, we examined 9 case-control studies, with a total of 3142 cancer cases and 3670 healthy controls. Meta-analysis results showed that the homozygote (CC) of rs2705897 in the CASP-3 gene is positively associated with cancer susceptibility [odds ratio (OR) = 4.36, 95% confidence interval (CI) = 1.26-15.11, P = 0.02], while the C allele and C carrier (TC+CC) of rs1049216 are negatively associated with cancer risk (OR = 0.81, 95%CI = 0.69-0.95, P = 0.01; OR = 0.78, 95%CI= 0.63-0.97, P = 0.02, respectively). The G allele and G carrier of rs4647603 (A/G) in CASP-3 had positive associations with cancer susceptibility (OR = 1.69, 95%CI = 1.37-2.09, P < 0.001; OR = 1.93, 95%CI = 1.26-2.93, P = 0.002, respectively). The T allele of rs12415607, the G allele and homozygote (GG) of rs2227310, and homozygote (CC) of rs3124740 also had positive associations with cancer risk (OR = 1.18, 95%CI = 1.02-1.37, P = 0.03; OR = 1.17, 95%CI = 1.01-1.34, P = 0.03; OR = 1.34, 95%CI = 1.04-1.74, P = 0.03; OR = 1.30, 95%CI = 1.04-1.63, P = 0.02, respectively). In addition, homozygote (AA) of rs11196418 showed a significant negative association with cancer risk (OR = 0.36, 95%CI = 0.14-0.93, P = 0.03). These meta-analysis results demonstrated that CASP-3 and CASP-7 genetic polymorphisms are involved in the pathogenesis of cancer.

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Section: Introductionmentioning

confidence: 99%

HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk

Yan¹,

Li²,

Zhu³

et al. 2013

Genet. Mol. Res.

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“…Inappropriate regulation of apoptosis contributes to a number of human disorders (6). Caspases are also of fundamental importance in mediating apoptosis (11).…”

Section: Discussionmentioning

confidence: 99%

“…Apoptosis, also known as programmed cell death, is a necessary genetically controlled process that is important in sustaining the balance of the development and maintenance of tissue homeostasis in multi-cellular organisms. Therefore, inappropriate regulation of apoptosis results in various human disorders, including cancer (3)(4)(5)(6). The two main apoptotic pathways in humans, the extrinsic or death receptor-mediated pathway and the intrinsic or mitochondrial pathway, both utilize the caspase enzyme cascade.…”

Section: Introductionmentioning

confidence: 99%

CASP-1, -2 and -5 gene polymorphisms and cancer risk: A review and meta-analysis

et al. 2013

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Abstract. Accumulating evidence suggests the CASP gene family is important in the development of carcinogenesis. These genetic polymorphisms have been extensively investigated as a potential risk factor for cancer, but results have been inconclusive. This Human Genome Epidemiology (HuGE) review and meta-analysis was performed to investigate the associations between CASP-1, -2 and -5 and cancer risk. A literature search of Pubmed, Embase, Web of Science and CBM databases was conducted from inception through September 1st, 2012. Four case-control studies with a total of 1,592 cancer cases and 1,833 healthy controls were included in the present meta-analysis. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Five polymorphisms were examined, including rs501192 (G>A), rs4647297 (C>G), rs507879 (T>C), rs3181320 (G>C) and rs523104 (G>C). Meta-analysis results showed that the rs3181320*C allele/carrier were associated with increased risk of various types of cancers (OR=1.26; 95% CI, 1.04-1.54; P=0.020 and OR=1.33; 95% CI, 1.00-1.75; P=0.047, respectively). However, similar associations were not found in the rs501192, rs4647297, rs507879 and rs523104 polymorphisms (all P>0.05). Results from the current meta-analysis suggest that the rs3181320*C allele/carrier in CASP-5 gene are potential risk factors for cancer.

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“…If the number of clusters is not known, it can be calculated using a proper function called the cluster validity index [12,13]. The two most commonly used fuzzy validity indexes are the partitioning entropy (PE) index [14] and the Xie-Beni index [15].…”

Section: The Application Of Validity Index To Raise Spatial Resolutionmentioning

confidence: 99%

Optimal three-dimensional reconstruction for lung cancer tissues

Huang¹,

Yue²,

Wang³

et al. 2017

THC

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Abstract. The existing three-dimensional (3D) x-ray reconstruction methods for lung cancer tissue reconstruct the investigated objects based on a series of two-dimensional (2D) image sections and a chosen 3D reconstruction algorithm. However, because these procedures apply the same segmentation method for all 2D image sections, they may not achieve the optimal segmentation for each section. As a result, the reconstructed 3D images have limited spatial resolution. Furthermore, the existing 3D reconstruction method is time-consuming and results in a limited time resolution. This research presents an innovation of 3D reconstruction by reformulating two main components of the method. First, a validity index for fuzzy clustering is used to obtain the optimal segmentations of any 2D x-ray image. The process is realized by automatically determining the optimal number of clusters for the image. Second, unlike the existing 3D reconstruction methods, a fast-FCM algorithm is used to speed up the 2D image segmenting process, thereby raising the time resolution of the 3D reconstruction process. With the aid of commonly used VTK software, the proposed method has been used to visualize four classes of typical lung cancer tissues: adenocarcinoma, large cell carcinoma, small cell carcinoma, and squamous cell carcinoma. Experimental results validate the effectiveness and efficiency of the proposed algorithm. Thus, the method contributes a useful tool for x-ray-based 3D image reconstruction.

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Polymorphisms in the caspase-8 gene and the risk of lung cancer

Cited by 59 publications

References 33 publications

HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk

HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk

CASP-1, -2 and -5 gene polymorphisms and cancer risk: A review and meta-analysis

Optimal three-dimensional reconstruction for lung cancer tissues

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