Polymorphisms in sulfotransferase 1A1 and glutathione S-transferase P1 genes in relation to colorectal cancer risk and patients’ survival

Sun, Xiaoying; Ahmadi, Ahmad; Arbman, Gunnar; Wallin, Åsa; Asklid, Daniel; Zhang, Hong

doi:10.3748/wjg.v11.i43.6875

Cited by 32 publications

(20 citation statements)

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“…This suggests the mutant allele is randomly distributed in cancer and control cases. Our results are in harmony with the findings of many other reports, who found no effect of the genotype for GSTP1 on colorectal cancer susceptibility (Welfare et al, 1999;Loktionov et al, 2001;Seow et al, 2002;Ates et al, 2005;Sun et al, 2005). Furthermore, they found that the frequencies for the Val-105 allele were 0.33 for controls, and 0.31 for cases, which are almost similar to that of the present study 0.29 and 0.27 for controls and cancer cases respectively (Welfare et al, 1999).…”

Section: Discussionsupporting

confidence: 93%

“…Although the sample size is small in the present study, the frequency of Ile105Val GSTP1 genotypes in 56 unaffected controls (0.43 for Ile/Ile, 0.553 for Ile/Val, and 0.017 for Val/Val) are consistent with those published for other Caucasian type control cohorts such as controls from East Anglia region (0.40, 0.49, 0.11) (Loktionov et al, 2001). And slightly different from those from Newcastle and North Tyneside, England (0.449, 0.427, 0.117) (Welfare et al, 1999), Swedish control group (0.50, 0.40, 0.10) (Sun et al, 2005), and for random control individuals Caucasian type from the Edinburgh area (0.51, 0.425, 0.065) (Harries et al, 1997).…”

Section: Discussionsupporting

confidence: 88%

“…GSTP1 has a polymorphic site at codon 105 (exon 5), where an A to G transition causes an Ile to Val substitution (Ile105Val), resulting in lower enzyme activity to variety of electrophilic molecules (Millar et al, 1999;Hayes et al, 2005;McIlwain et al, 2006). Numerous reports assessed the risk of colorectal cancer development in subjects carrying the variant Val GSTP1 allele; however, the results are controversial (Harries et al, 1997;Welfare et al, 1999;Kiyohara, 2000;Grubben et al, 2001;Loktionov et al, 2001;Seow et al, 2002;Ates et al, 2005;Sun et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

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The GSTP1 Ile105Val Polymorphism is not Associated with Susceptibility to Colorectal Cancer

Khabaz

2012

Asian Pacific Journal of Cancer Prevention

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The glutathione S transferase (GST) family is a major part of cellular defense mechanisms against endogenous and exogenous substances, many of which have carcinogenic potential. Alteration in the expression level or structure of the glutathione-S-transferase (GST) enzymes may lead to inadequate detoxification of potential carcinogens and consequently contribute to cancer development. A member of the glutathione-S-transferase (GST) family, GSTP1, is an attractive candidate for involvement in susceptibility to carcinogen-associated colorectal cancer. An AgG transition in exon 5 resulting in an Ile105Val amino acid substitution has been identified which alters catalytic efficiency. The present study investigated the possible impact of Ile105Val GSTP1 polymorphism on susceptibility to colorectal cancer. in Jordan We examined 90 tissue samples previously diagnosed with colorectal carcinoma, and 56 non-cancerous colon tissues. DNA was extracted from paraffin embedded tissues and the status of the GSTP1 polymorphism was determined using a polymerase chain reaction restriction fragment length polymorphism (RFLP) method. No statistically significant differences were found between colorectal cancer cases and controls for the GSTP1 Ile/Ile, Ile/Val and Val/Val genotypes. The glutathione S-transferase polymorphism was not associated with risk in colorectal cancer cases in Jordan stratified by age, sex, site, grade or tumor stage. In conclusion, the GSTP1 Ile105Val polymorphism is unlikely to affect the risk of colorectal cancer.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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The GSTP1 Ile105Val Polymorphism is not Associated with Susceptibility to Colorectal Cancer

Khabaz

2012

Asian Pacific Journal of Cancer Prevention

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“…The 105 Val variant of GSTP1 has been correlated with the development of several types of cancer including bladder, 9 testicular, 9 lung cancer, 10,11 breast cancer, 12 esophageal, 13 and oropharyngeal cancer, 14 as well as a poor prognosis in patients with colorectal cancer. 15 By contrast, other studies have shown opposite results 16 or no association between GSTP1 polymorphisms and cancer type. [17][18][19] Several studies have assessed the relationship between GSTP1 and gastric cancer and have found no original article association.…”

Section: Introductionmentioning

confidence: 62%

“…The conditions were initially The PCR products of GSTP1 (GenBank accession number: NM_000852) were then digested overnight with 5 units of the restriction enzyme Alw26I (New England Biolabs, Ipswich, MA, USA), which distinguishes between the Ile and the Val alleles. 9,15 The digestion products were separated in 3.5% agarose gels. This resulted in 176 bp (-GSTP1 A) or 85 and 91 bp (-GSTP1 G) products.…”

Section: Genotyping Of Gstp1mentioning

confidence: 99%

Effects of Genetic Polymorphisms of Glutathione S-transferase P1 on Helicobacter pylori-associated Gastric Cancer

Kang¹,

Kim²,

Cho³

et al. 2008

Gut Liver

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Background/Aims: Glutathione S-transferase P1 (GSTP1) scavenges radicals via its peroxidase activity. The purpose of this study was to determine the association of GSTP1 genetic polymorphisms with the expression of H. pylori-associated gastroduodenal disease. Methods: This study involved 1,911 subjects, comprising patients with four diseases (gastric cancer, dysplasia, benign gastric ulcer, and duodenal ulcer disease) and controls. Biallelic polymorphisms were genotyped by restriction fragment length polymorphism techniques. Results: The frequency of the genetic polymorphism at nucleotide 313 of GSTP1 did not differ among the five study groups. However, when the gastric cancer group was subdivided into advanced gastric cancer (AGC) and early gastric cancer, the frequency of the G/G genotype was significantly higher in the AGC group than in all the control subgroups (OR: 1.2, 95% CI: 1.1-4.9). The frequency of this genotype differed significantly in the H. pylori-positive AGC group (OR: 2.7, 95% CI: 1.1-6.3) but not in the H. pylori-negative group. Furthermore, the difference was greater in the intestinal type, and was not found in diffuse types of disease. Conclusions: This study found that genetic polymorphisms of GSTP1 were associated with H. pylori-associated gastric cancer only during the advanced stage of gastric cancer, with intestinal-type histology evident in H. pylori-positive subjects. (Gut and Liver 2008;2:23-29)

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The Role of Chemical Carcinogens and Their Biotransformation in Colorectal Cancer

Marchand¹

2009

Genetics of Colorectal Cancer

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Polymorphisms in sulfotransferase 1A1 and glutathione S-transferase P1 genes in relation to colorectal cancer risk and patients’ survival

Abstract: Polymorphism in SULT1A1 may predispose to colorectal cancer and GSTP1 may be a biological indicator of prognosis in the patients.

Cited by 32 publications

References 20 publications

The GSTP1 Ile105Val Polymorphism is not Associated with Susceptibility to Colorectal Cancer

The GSTP1 Ile105Val Polymorphism is not Associated with Susceptibility to Colorectal Cancer

Effects of Genetic Polymorphisms of Glutathione S-transferase P1 on Helicobacter pylori-associated Gastric Cancer

The Role of Chemical Carcinogens and Their Biotransformation in Colorectal Cancer

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