Abstract:Background
Chronic venous disease (CVD) is a common disorder of lower extremities.
Objectives
The study was scheduled to investigate the relationship between polymorphisms in major proinflammatory genes TNF α (−238 A/G; −308 A/G), TNF β (NcoI), IL‐1β (+3953 T/C); IL‐6 (−174 G/C; −596 G/C) and ADAM17 (3′TACE) and CVD risk. Genotype–phenotype study was calculated to test possible association between examined genotypes and phenotypes of CVD.
Methods
Finally, 150 CVD patients and 227 control subjects were enrolled… Show more
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