Polymorphisms in oxidative stress, metabolic detoxification, and immune function genes, maternal exposure to ambient air pollution, and risk of preterm birth in Taiyuan, China

Zhao, Nan; Wu, Weiwei; Feng, Yongliang; Yang, Feifei; Han, Tianbi; Guo, Mengzhu; Ren, Q W; Li, Wangjun; Li, Jinbo; Wang, Suping; Zhang, Yawei

doi:10.1016/j.envres.2020.110659

Cited by 21 publications

(14 citation statements)

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“…Wildfire smoke is a complex mixture containing gaseous pollutants, organic compounds, and fine particles, much of which is similar to pollution from combustion, smoking, and other sources [45,46]. These pollutants may impact pregnancy health through a few mechanisms including endothelial dysfunction, endocrine disruption, immunologic dysfunction, systemic inflammation, and oxidative stress [47][48][49][50][51]. These changes ultimately reduce maternal-placental-fetal blood flow and nutrient/oxygen exchange or induce epigenetic changes that can impact fetal growth [52].…”

Section: Wildfiresmentioning

confidence: 99%

The Changing Climate and Pregnancy Health

2022

Curr Envir Health Rpt

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Purpose of Review Climate change is the biggest public health threat of the twenty-first century but its impact on the perinatal period has only recently received attention. This review summarizes recent literature regarding the impacts of climate change and related environmental disasters on pregnancy health and provides recommendations to inform future adaptation and mitigation efforts. Recent Findings Accumulating evidence suggests that the changing climate affects pregnancy health directly via discrete environmental disasters (i.e., wildfire, extreme heat, hurricane, flood, and drought), and indirectly through changes in the natural and social environment. Although studies vary greatly in design, analytic methods, and assessment strategies, they generally converge to suggest that climate-related disasters are associated with increased risk of gestational complication, pregnancy loss, restricted fetal growth, low birthweight, preterm birth, and selected delivery/newborn complications. Window(s) of exposure with the highest sensitivity are not clear, but both acute and chronic exposures appear important. Furthermore, socioeconomically disadvantaged populations may be more vulnerable. Summary Policy, clinical, and research strategies for adaptation and mitigation should be continued, strengthened, and expanded with cross-disciplinary efforts. Top priorities should include (a) reinforcing and expanding policies to further reduce emission, (b) increasing awareness and education resources for healthcare providers and the public, (c) facilitating access to quality population-based data in low-resource areas, and (d) research efforts to better understand mechanisms of effects, identify susceptible populations and windows of exposure, explore interactive impacts of multiple exposures, and develop novel methods to better quantify pregnancy health impacts.

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Section: Wildfiresmentioning

confidence: 99%

The Changing Climate and Pregnancy Health

2022

Curr Envir Health Rpt

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“…Due to the small sample size, chance findings cannot be ruled out, and the large variance of the estimator might make association toward the null. The distributions of selected characteristics were different between the study population and the excluded population in the entire birth cohort (supplementary table 3) [44], which raised a concern about representativeness of the entire birth cohort and generalizability of the study results to other populations. Future studies are needed to replicate our results in different populations with greater statistical power.…”

Section: Discussionmentioning

confidence: 99%

Effects of Benzo[a]pyrene-DNA adducts, dietary vitamins, folate, and carotene intakes on preterm birth: a nested case–control study from the birth cohort in China

Zhao

Cui

et al. 2022

Environ Health

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Background Polycyclic aromatic hydrocarbons (PAHs) and its DNA adducts has been suggested to increase the risk of preterm birth (PB). Yet, few studies have been conducted to investigate this association, and the role of dietary nutrients intakes including vitamins, folate, and carotene during pre- and post-conception on this association has not been studied. Methods Building upon a birth cohort in Taiyuan China, we conducted a nested case control study including 83 PB and 82 term births. Benzo[a]pyrene (BaP)-DNA adducts were measured by an improved LC-MC/MC analytic method. Dietary nutrient intakes were estimated from food frequency questionnaire using the Chinese Standard Tables of Food Consumption. Multivariable logistic regression model was used to examine the associations. Results Increased risk of PB was observed as per interquartile increase in maternal BaP-DNA adduct level (OR = 1.27, 95%CI 0.95–1.67). Compared to low level (below mean) of maternal adducts, high level (above mean) of adducts was associated with the risk of PB (OR = 2.05, 95%CI 1.05–4.01). After stratified by dietary nutrients intakes, high adducts levels were associated with approximately 2–fourfold times increases in risk of PB among women with low vitamin A, C, E, folate, and carotene intakes during pre- and/or post-conception. Stronger stratified associations were consistently seen during preconception. Similar patterns were observed after additional adjustment for supplementation. Conclusions Our study supports the hypothesis that high level of maternal PAHs exposure was significantly associated with increased risk of PB, and provides the first evidence that dietary vitamins, carotene, and folate intake levels may modify this association during different pregnancy windows. Our findings are relevant to identify recommendation for environment management and prenatal nutrition regarding pregnant women and newborns. Further investigation in other populations is warranted.

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“…Studies on the effects of different components of PM 2.5 on birth outcomes have shown that the component elements of carbon, calcium, copper, nickel, titanium, zinc, aluminum, and antimony are associated with low birth weight ( 36 ). The toxicological effects of metal components are inferred as well, mainly by increasing oxidative stress ( 37 ). The biological mechanisms related to VLBW, however, need to be further investigated and explored in the future.…”

Section: Discussionmentioning

confidence: 99%

Associations between maternal exposure to ambient air pollution and very low birth weight: A birth cohort study in Chongqing, China

Zhou

Ming²,

Yang³

et al. 2023

Front. Public Health

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IntroductionThere have been many researches done on the association between maternal exposure to ambient air pollution and adverse pregnancy outcomes, but few studies related to very low birth weight (VLBW). This study thus explores the association between maternal exposure to ambient air pollutants and the risk of VLBW, and estimates the sensitive exposure time window.MethodsA retrospective cohort study analyzed in Chongqing, China, during 2015–2020. The Generalized Additive Model were applied to estimate exposures for each participant during each trimester and the entire pregnancy period.ResultsFor each 10 μg/m3 increase in PM2.5 during pregnancy, the relative risk of VLBW increased on the first trimester, with RR = 1.100 (95% CI: 1.012, 1.195) in the single-pollutant model. Similarly, for each 10 μg/m3 increase in PM10, there was a 12.9% (RR = 1.129, 95% CI: 1.055, 1.209) increase for VLBW on the first trimester in the single-pollutant model, and an 11.5% (RR = 1.115, 95% CI: 1.024, 1.213) increase in the multi-pollutant model, respectively. The first and second trimester exposures of NO2 were found to have statistically significant RR values for VLBW. The RR values on the first trimester were 1.131 (95% CI: 1.037, 1.233) and 1.112 (95% CI: 1.015, 1.218) in the single-pollutant model and multi-pollutant model, respectively; The RR values on the second trimester were 1.129 (95% CI: 1.027, 1.241) and 1.146 (95% CI: 1.038, 1.265) in the single-pollutant model and multi-pollutant model, respectively. The RR of O3 exposure for VLBW on the entire trimester was 1.076 (95% CI: 1.010–1.146), and on the second trimester was 1.078 (95% CI: 1:016, 1.144) in the single-pollutant model.ConclusionThis study indicates that maternal exposure to high levels of PM2.5, PM10, NO2, and O3 during pregnancy may increase the risk of very low birth weight, especially for exposure on the first and second trimester. Reducing the risk of early maternal exposure to ambient air pollution is thus necessary for pregnant women.

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Polymorphisms in oxidative stress, metabolic detoxification, and immune function genes, maternal exposure to ambient air pollution, and risk of preterm birth in Taiyuan, China

Cited by 21 publications

References 50 publications

The Changing Climate and Pregnancy Health

The Changing Climate and Pregnancy Health

Effects of Benzo[a]pyrene-DNA adducts, dietary vitamins, folate, and carotene intakes on preterm birth: a nested case–control study from the birth cohort in China

Associations between maternal exposure to ambient air pollution and very low birth weight: A birth cohort study in Chongqing, China

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