Polymorphisms in &lt;i&gt;NOS3, ACE &lt;/i&gt;and&lt;i&gt; PAI-1&lt;/i&gt; Genes and Risk of Spontaneous Recurrent Miscarriage in the Gaza Strip

Sallout, Rami J. Al; Sharif, Fadel A.

doi:10.1159/000273067

Cited by 35 publications

(35 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This suggests a possible role for ethnic differences as a result of genetic backgrounds and the environment. The same results were proposed by Shufang Zhang et al [36] and Ozturk Ozdemir et al [37] in their recent work, even though the incompatible viewpoints were revealed by other studies [32,33,35]. In addition, because the frequency of allele could affect the results of genetic association studies, the genetic background of RPL was evaluated.…”

Section: Subgroups Results and Sensitivity Analysismentioning

confidence: 52%

“…While reading the full texts, the following articles were removed: two studies did not meet Hardy-Weinberg equilibrium (P 0 0.0003 and P 0 0.0217, respectively) [25,26]; one study could not extract the allele data (ACE I/D in RPL) from its groups [27]; one study was not only focused on RPL, but also on pre-eclampsia and foetal growth restriction which made it hard to get the data required [28]; and the other two studies included the data of case and control groups, but little information about the ACE I/D polymorphism [16,29]. Finally, there were 9 studies meeting the inclusion criteria that were included [11,[30][31][32][33][34][35][36][37]. Among the collected studies, five investigated Caucasian populations [11,30,31,34,37], and the others investigated Asian patients [33,34,36,37].…”

Section: Characteristicsmentioning

confidence: 99%

“…The case populations had no history of chronic infections, thromboses, autoimmune diseases, endocrinologic disorders, a After the sensitive analysis, remove the article of heterogeneity. [30] or congenital anomalies [11,[30][31][32][33][34][35][36][37]. All of the cases came from the hospital, and the controls were limited to patients having delivered at least one healthy, term infant with no history of pregnancy loss or healthy volunteers.…”

Section: Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Angiotensin-converting enzyme insertion/deletion (I/D) polymorphisms and recurrent pregnancy loss: a meta-analysis

Chen

et al. 2012

J Assist Reprod Genet

View full text Add to dashboard Cite

Background Recurrent pregnancy loss (RPL) had said to be related to the angiotensin converting enzyme insertion/deletion polymorphisms (ACE I/D) gene polymorphisms. But the conclusions were controversial. This meta-analysis was conducted to investigate the real association in ACE I/D polymorphisms and RPL firstly. Methods Combine Pubmed Embase and HuGENet database in data analysis for this meta-analysis from October 2000 to November 2011. The metagen system was used to select the models and effects. Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association. Results 9 studies from six countries with 1264 RPL and 845 controls were included according to our criterion. Following the metagen system, we used the dominant model with random effects. The summary OR 01.61 (95% CI: 1.10-2.36, I 2 0 59.0%), which suggested the ACE D allele might increase the RPL risk in Asia (OR01.97, 95% CI: 1.31-2.98, I 2 0 44.4%), among Asians (OR01.69, 95% CI: 1.06-2.36, I 2 032.7%). In additional, after conducting sensitivity analysis, the results had no differences except for Caucasian subgroup reached to the significance (OR02.059, 95% CI: 1.455-2.914), so we couldn't ignore the relationship between the polymorphisms of ACE D/I gene and Caucasians yet. There seemed no publication bias in our eligible studies with Begg's test (P 0 0.867). Conclusions Results in this meta-analysis presented the positive function of the ACE I/D polymorphism in increasing the RPL risk. Furfure prospective studies were needed to confirm the precise relationship between the ACE I/D and RPL.

show abstract

Section: Subgroups Results and Sensitivity Analysismentioning

confidence: 52%

Section: Characteristicsmentioning

confidence: 99%

Section: Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Angiotensin-converting enzyme insertion/deletion (I/D) polymorphisms and recurrent pregnancy loss: a meta-analysis

Chen

et al. 2012

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…Endothelial nitric oxide synthase activity has been studied in the context of implantation and maintenance of pregnancy. Given this, few studies have attempted to study the polymorphisms within this gene in RM cases [52][53][54]. Only Shin et al could demonstrate a positive association of this gene with RM among their cohort of Korean women [53].…”

Section: Other Genetic Markersmentioning

confidence: 99%

Genetic factors influencing recurrent pregnancy loss: lessons learnt from recent studies

Dasgupta

Aruna

Reddy³

2012

Expert Review of Obstetrics & Gynecology

View full text Add to dashboard Cite

Recurrent spontaneous abortions, also known as recurrent miscarriages (RMs), of unknown etiology provide a fundamental basis to understand the processes of embryogenesis and implantation. It is a distressing condition for the couple as well as the treating clinician. RM presents a varied etiology with a different combination of factors playing a role in its manifestation. Despite recent advances in the investigation and management of RM, a relatively large proportion of the cases remain idiopathic. An abortion is any loss before 20 gestational weeks [1]. RM is defined as the loss of two or more consecutive pregnancies spontaneously before the 24th week of gestation [2]. The modern definition, however, is the spontaneous loss of two or more consecutive pregnancies before 20 weeks of gestation [3,4]. A large number of pathological factors have been attributed to the etiology of RM, including chromosomal abnormalities, anatomic defects, immunological factors, endocrine disturbances and thrombophilia, to name a few. This has inevitably led to an understanding of the molecular genetic basis of these etiological factors, primarily with regard to the immunological and thrombophilic factors. Consequently, there has been a constant rise in the number of genetic association studies in different populations, including those from India. However, a definite conclusion on the molecular genetic etiology of RM is still lacking. In this article, we present a comprehensive review of such molecular genetic association studies based on the underlying genetic factors of three major etiologic categories in RM: immunological factors, thrombophilic factors and endocrine factors. Etiology of RM Genetic disordersChromosomal abnormalities occur in 50% of all conception products from first-trimester miscarriages, 5% of late pregnancy miscarriages and 0.5% of live births. These chromosomal anomalies could be due to aneuploidy (monosomy, trisomy and polyploidy) or structural abnormalities, such as translocations and inversions. Approximately 3% of cytogenetically abnormal conceptions are due to structural rearrangements [5]. Anatomical disordersAnatomical investigations are normally performed by hysterosalpingography, hysteroscopy or ultrasound scans. However, hysteroscopy and advanced imaging techniques (3D ultrasonography and MRI) and laparoscopy (if necessary) Recurrent miscarriage (RM) is the loss of three or more consecutive pregnancies before the 24th week of gestation. RM occurs chiefly owing to either a problem with the pregnancy or the environment where it implants and further development occurs. A large number of pathological factors have been attributed to the etiology of RM. A number of genetic association studies in different populations, including that of India, have been conducted, yet with no definite conclusions. This review analyzes various genetic association studies that have been conducted based on the underlying immunological, thrombophilic and endocrine factors in RM, and outlines the salient features of the findings an...

show abstract

“…In the literature there are some reports on the association between eNOS gene polymorphisms and IRM. However, the results of these studies have been controversial among different ethnic groups (6)(7)(8)(9)(10)(11). In this study we aimed to determine whether eNOS gene polymorphisms are associated with an increased risk for IRM in the Turkish population and to evaluate the association between NO levels and eNOS gene polymorphisms in women with IRM.…”

Section: Introductionmentioning

confidence: 97%

Nitric oxide levels and endothelial nitric oxide synthase gene polymorphisms in Turkish women with idiopathic recurrent miscarriage

Öztürk

Balat

Pehlıvan

et al. 2011

J Turkish German Gynecol Assoc

View full text Add to dashboard Cite

Objective: To determine whether endothelial nitric oxide synthase (eNOS) gene polymorphisms are associated with an increased risk for Idiopathic Recurrent Miscarriage (IRM) in the Turkish population and to evaluate the association between Nitric Oxide (NO) levels and eNOS gene polymorphisms in women with IRM. Material and Methods:A total of 120 Turkish women were enrolled in this study in four groups. Of these, 30 women were first trimester pregnant who had IRM (Group I). Thirty healthy multipara women were in the first trimester of pregnancy with no history of abortion (Group II). Thirty women were non pregnant with a history of IRM (Group III). The remaining 30 subjects were healthy multipara nonpregnant women with no history of abortion (Group IV). DNA analysis of four groups were performed for the two polymorphisms using the PCR and/or PCR-RFLPs method and NO levels were measured spectrophotometrically. Results:We observed statistically significant decreased NO levels in the pregnant patient group (p=0.001) while elevated NO levels were measured in the non pregnant patient group (p=0.004). We demonstrated that,while there was no significant difference in terms of VNTR 4/eNOS genotype, there was a marginally significant difference in terms of Glu298Asp/eNOS genotype frequency (p=0.055) in patients with IRM in the Turkish population. We observed no association between NO levels and Glu298Asp/eNOS or VNTR 4/eNOS genotypes in any of the groups. Conclusion:The Glu298Asp polymorphism of eNOS could be an intriguing susceptibility factor that modulates an individual's risk of IRM in Turkish population. Further studies to explain the role of the NO pathway in the pathophysiology of IRM are needed. (J Turkish-German Gynecol Assoc 2011; 12: 234-8)

show abstract

Polymorphisms in <i>NOS3, ACE </i>and<i> PAI-1</i> Genes and Risk of Spontaneous Recurrent Miscarriage in the Gaza Strip

Cited by 35 publications

References 57 publications

Angiotensin-converting enzyme insertion/deletion (I/D) polymorphisms and recurrent pregnancy loss: a meta-analysis

Angiotensin-converting enzyme insertion/deletion (I/D) polymorphisms and recurrent pregnancy loss: a meta-analysis

Genetic factors influencing recurrent pregnancy loss: lessons learnt from recent studies

Nitric oxide levels and endothelial nitric oxide synthase gene polymorphisms in Turkish women with idiopathic recurrent miscarriage

Contact Info

Product

Resources

About