Polymorphisms in LRP2 and CUBN genes and their association with serum vitamin D levels and sleep apnea
Dimitra Anatolou,
Paschalis Steiropoulos,
Athanasios Zissimopoulos
et al.
Abstract:Purpose
Vitamin D deficiency has been associated with the occurrence of obstructive sleep apnea syndrome (OSAS). Megalin (LRP2) and cubilin (CUBN) are implicated in vitamin D metabolism, whereas LRP2 and CUBN polymorphisms have been previously associated with variable serum vitamin D levels. The present study aimed to evaluate the role of LRP2 rs2228171 c.8614C > T and CUBN rs1801222 c.758A > G polymorphisms in OSAS susceptibility, independently or in synergy with vitamin D levels.
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