Polymorphisms in lncRNA HOTAIR and susceptibility to breast cancer in a Chinese population

Yan, Rui; Cao, Jingjing; Song, Chunhua; Chen, Yi; Wu, Zhenzhen; Wang, Kaijuan; Dai, Liping

doi:10.1016/j.canep.2015.10.025

Cited by 63 publications

(81 citation statements)

References 35 publications

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“…Previous studies on the contribution of rs920778 to gastric cancer in a Turkish population [25] also showed no differences between patients and cancer-free controls; however, studies in other tumor types testing the importance of rs920778 or rs12826786 in the Chinese population have shown different allele frequencies between patients and cancer-free controls [22][23][24]. It was also showed previously that rs920778 variants do not influence gastric cancer susceptibility [25], whereas others have showed statistically significant associations between these SNPs and risk to develop gastric cardia adenocarcinoma [22], esophageal squamous cell carcinoma (ESCC) [23], breast cancer [26][27][28] or gastric cancer [24]. Such discrepancies might be attributed to the different genetic backgrounds of the studied populations, different sample sizes, and/or to the variety of tumor types analyzed.…”

Section: Discussionmentioning

confidence: 91%

“…Although HOTAIR expression has been reported as crucial in the carcinogenic process of many cancer types, and its abnormal expression was associated with patient poor prognosis, tumor grade, growth and invasion, and as a putative therapeutic target in glioma [19][20][21], few studies have focused on the significance of SNPs in HOTAIR affecting cancer risk [22][23][24][25][26][27][28]. Critically, no studies have evaluated the impact of HOTAIR SNPs in glioma risk and patient prognosis.…”

Section: Introductionmentioning

confidence: 99%

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Effects of the functional HOTAIR rs920778 and rs12826786 genetic variants in glioma susceptibility and patient prognosis

et al. 2017

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restriction fragment length polymorphism (RFLP). No statistically significant differences were found in the genotype or allele distributions of either rs920778 or rs12826786 between glioma patients and controls, suggesting these SNPs are not associated with glioma risk. No significant associations were found between rs920778 variants and HOTAIR expression levels, while rs12826786 CT genotype was associated with increased intratumoral HOTAIR RNA levels when compared to TT genotype (p-value = 0.04). Univariate (Log-rank) and multivariate (Cox proportional) analyses showed both rs920778 CT and rs12826786 CT genotypes were significantly associated with longer overall survival of WHO grade III anaplastic oligodendroglioma patients. Our results suggest that HOTAIR SNPs rs920778 and rs12826786 do not play a significant role in glioma susceptibility, but may be important prognostic factors in anaplastic oligodendroglioma patients. Future studies are warranted to validate and expand these findings, and to further dissect the importance of these SNPs in glioma.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Effects of the functional HOTAIR rs920778 and rs12826786 genetic variants in glioma susceptibility and patient prognosis

et al. 2017

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“…B16F10 cells (1x10 6 ) were plated on 6-well culture plates and co-cultured with different concentrations (0-10 µM) of propofol (Sigma-Aldrich; Merck KGaA) for 24 or 48 h at 37˚C. Apoptosis of murine melanoma B16F10 cells was determined using Annexin V-fluorescein isothiocyanate (FITC)/propidium iodide (PI) (Vybrant; Invitrogen; Thermo Fisher Scientific, Inc.).…”

Section: Methodsmentioning

confidence: 99%

“…B16F10 cells (1x10 6 ) were incubated on 6-well culture plates and co-cultured with different concentrations (0-10 µM) of propofol (Sigma-Aldrich; Merck KGaA) for 24 or 48 h. The total protein from cervical cancer cells was isolated using radioimmunoprecipitation assay lysis buffer (Beyotime Institute of Biotechnology) with protease or phosphatase inhibitors (Beyotime Institute of Biotechnology). The protein concentration was quantified using bicinchoninic acid protein assay kit (Beyotime Institute of Biotechnology).…”

Section: Methodsmentioning

confidence: 99%

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Propofol promotes apoptosis and suppresses the HOTAIR-mediated mTOR/p70S6K signaling pathway in melanoma cells

et al. 2017

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Abstract.Propofol is an intravenous anesthetic, which is widely used in clinical anesthesia induction and maintenance and is critical in the sedation of patients. However, the functions and mechanisms of propofol on apoptosis of melanoma cells remain unclear. The present study investigated whether propofol promotes cell apoptosis and suppresses the HOX transcript antisense RNA (HOTAIR)-mediated mechanistic target of rapamycin (mTOR) pathway in melanoma cells. B16F10 cells were cultured with different concentrations (0-10 µM) of propofol for 24 or 48 h. Proliferation and apoptosis of B16F10 cells were detected using MTT assay and flow cytometry. The pcDNA 3

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Genetic variants in a long noncoding RNA related to Sunitinib Resistance predict risk and survival of patients with renal cell carcinoma

Xing

et al. 2019

Cancer Medicine

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Objective LncARSR (lncRNA Activated in RCC with Sunitinib Resistance, ENST00000424980) is a newly identified lncRNA to promote the sunitinib resistance of renal cell carcinoma (RCC), which may contribute to tumorigenesis and progression. This study aimed to explore the association of lncARSR tagSNPs with the risk and prognosis of RCC. Methods In this study, a 2‐stage case‐control study was performed to evaluate the association between 2 tagging SNPs (rs1417080 and rs7859384) and RCC susceptibility. Odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by unconditional logistic regression analyses. Different survival time was estimated by the Kaplan‐Meier method and compared by the Log‐rank test. Hazard ratios (HRs) and their 95% CIs were calculated to determine predictive factors by Cox proportion hazards model. Results When combing discovery and validation sets together, rs7859384 was determined to be significantly associated with the decreased RCC risk with all P < 0.05 in 4 models (co‐dominant model, additive model, dominant model and recessive model). stratified analyses showed prominent risk effect of SNP rs7859384 GA/GG genotypes was found in clinical subgroups of stage I and stage II (P = 0.009, OR = 0.77, 95% CI = 0.64‐0.94) and individuals with clear cell RCC (P = 0.014, OR = 0.79, 95% CI = 0.65‐0.95). A protective effect of SNP rs7859384 GA/GG genotypes was observed among individuals with BMI > 24 (P = 0.025, OR = 0.74, 95% CI = 0.56‐0.96), without hypertension (P = 0.037, OR = 0.79, 95% CI = 0.63‐0.99), without family history of cancer (P = 0.048, OR = 0.83, 95% CI = 0.68‐1.00). Survival analyses revealed individuals with GA/GG genotypes had higher survival rate compared with the corresponding AA wild genotypes in the dominant model (log‐rank P = 0.005, adjusted HR = 0.34, 95% CI = 0.16‐0.73). Conclusion This study suggests that rs7859384 of lncARSR was associated with RCC susceptibility and may act as a prognostic biomarker for patients with RCC.

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Polymorphisms in lncRNA HOTAIR and susceptibility to breast cancer in a Chinese population

Cited by 63 publications

References 35 publications

Effects of the functional HOTAIR rs920778 and rs12826786 genetic variants in glioma susceptibility and patient prognosis

Effects of the functional HOTAIR rs920778 and rs12826786 genetic variants in glioma susceptibility and patient prognosis

Propofol promotes apoptosis and suppresses the HOTAIR-mediated mTOR/p70S6K signaling pathway in melanoma cells

Genetic variants in a long noncoding RNA related to Sunitinib Resistance predict risk and survival of patients with renal cell carcinoma

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